[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-324513-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-324513-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","peripheral-blood-glucose-and-cardiopulmonary-resuscitation","PERIPHERAL BLOOD GLUCOSE - AND CARDIOPULMONARY RESUSCITATION","","Forensic analysis discusses postmortem hyperglycemia in non-diabetics, emphasizing that peripheral blood glucose can become markedly elevated after asphyxia or terminal events. It summarizes prior findings on peripheral hyperglycemia and contrasts them with vitreous humor and cerebrospinal fluid, which better reflect significant antemortem glucose. A review of 1,000 medical examiner cases identified 102 non-diabetics with peripheral glucose >500 mg/dl but vitreous \u003C100 mg/dl, largely linked to modern resuscitative cardiac massage.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/peripheral-blood-glucose-and-cardiopulmonary-resuscitation/324513/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/peripheral-blood-glucose-and-cardiopulmonary-resuscitation/324513.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why can peripheral blood glucose be very high postmortem in non-diabetics?","Question",{"text":63,"@type":64},"High peripheral glucose may occur after asphyxia and terminal events due to mechanisms such as glycogenolysis, and it can be further amplified by modern resuscitative procedures during the terminal or postmortem interval.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do CSF and vitreous humor relate to diagnosing significant antemortem glucose elevation?",{"text":68,"@type":64},"Studies indicate that conditions causing terminal hyperglycemia do not appreciably change glucose values in CSF and vitreous humor, so these media are preferred when diagnosing significant antemortem elevations.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the 1,000-case review find about the relationship between peripheral and vitreous glucose?",{"text":72,"@type":64},"Among 1,000 cases with serum and vitreous glucose testing, 102 non-diabetics showed peripheral glucose >500 mg/dl while vitreous glucose was \u003C100 mg/dl, with most linked to cardiac massage during resuscitation.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},324513,1790438220,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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ANDCARDIOPULMONARY RESUSCITATION\n\n—John I.Coe,M.D.  \nWhile it is commonly recognized that blood fromthe right ventricle will frequently show very high levelsof glucose due to glycogenolysis in the liver,it is not sogenerally known that high levels of glucose may befound postmortem in blood from the peripheral circula-tion of non-diabetics.Claude Bernard first observed thatasphyxia could lead to such peripheral hyperglycemia.This has been substantiated experimentally by Hill¹whoshowed a progressive rise of left ventricular glucose toover 520 mg/dl in a dog slowly asphyxiated by repeatedintratracheal injections of liquid petrolatum.In humans,Hill found significant peripheral elevations of glucose ina variety of conditions including carbon monoxidepoisoning,increased intracranial pressure,and obstruc-tion of the upper respiratory tract.However,only twoof these cases had values exceeding 500 mg/di.Tongeand Wannan2 in a study of 145 deceased adults foundsix non-diabetics with postmortem hyperglycemia inperipheral vessels.These included two cases of hanging,two cases of acute coronary occlusion,one with cerebralhemorrhage and one due to electrocution.In none ofthese did the glucose level exceed 300 mg/dl while thelevel in most diabetics exceeded 500 mg/dl.  \nWith the introduction of cerebrospinal fluid andvitreous humor as media for analysis,it was found thatconditions producing a terminal hyperglycemia did notseem to change the values in these other media,and thusthe examination of CSF or vitreous became the pro-cedure of choice in diagnosing significant antemortemelevations of glucose content.However,in cases whereonly blood was available,I have felt that it was possibleto diagnose diabetic hyperglycemia when values forglucose in peripheral blood exceeded 500 mg/dl andwhen the individual did not die from any of the reportedconditions that might produce a terminal rise in theblood sugar³.  \nRecently I have reviewed one thousand consecu-tive medical examiner cases in which routine serum andvitreous glucose determinations were available.In all ofthese the blood specimens were taken from subclavianveins and both blood and vitreous samples were analyzedon a Technicon SMA 6/60 machine using a glucose  \noxidase-peroxidase procedure.A startling observation inthese 1,000 cases was the presence of 102 nondiabeticsin whom peripheral blood sugar values exceeded 500mg/dl while vitreous values were less than 100 mg/di.These represented 10.2%of the total group-a far farhigher percentage showing marked terminal peripheralglucose elevation than any previous report.Analysis ofthese 102 cases reveal that they fall into two distinctgroups.A large majority(83 individuals)had receivedmodern resuscitative measures with cardiac massagecarried on for 15 minutes to over an hour.A possibleexplanation of the high peripheral glucose in theseindividuals would be glycogenolysis occurring in theterminal and postmortem interval while closed cardiacmassage was being given.In these circumstances theglucose from glycogenolysis in the liver instead of simplydiffusing into the right ventricle would be forcedthroughout the entire circulation by the resuscitativeprocedure.  \nThe second group of 19 cases(1.9%of the totalseries)revealed high peripheral glucose in the absence ofany resuscitative procedures and correspond to the typeof cases previously reported.Within this group 12 diedfrom arteriosclerotic heart disease,3 from drowning,2from barbiturate poisoning,and one each from cirrhosis,a gunshot wound to the chest,hanging,and carbonmonoxide poisoning.  \nThe purpose of this brief communique is twofold.First it is to alert anyone trying to interpret bloodglucose levels that modern resuscitative techniques cancause very high peripheral values thus adding yet anotherproblem to diagnosing diabetic hyperglycemia.I nolonger feel secure in considering an eleva","cbCais0BwWbZxObb","https://ap.wps.com/l/cbCais0BwWbZxObb","pdf",1137973,"English","# Peripheral Blood Glucose and Cardiopulmonary Resuscitation\n## Key background on peripheral hyperglycemia postmortem\n## CSF and vitreous humor as diagnostic media\n## Review of 1,000 cases and two observed groups\n## Implications for interpreting diabetic hyperglycemia\n## References","[{\"question\":\"Why can peripheral blood glucose be very high postmortem in non-diabetics?\",\"answer\":\"High peripheral glucose may occur after asphyxia and terminal events due to mechanisms such as glycogenolysis, and it can be further amplified by modern resuscitative procedures during the terminal or postmortem interval.\"},{\"question\":\"How do CSF and vitreous humor relate to diagnosing significant antemortem glucose elevation?\",\"answer\":\"Studies indicate that conditions causing terminal hyperglycemia do not appreciably change glucose values in CSF and vitreous humor, so these media are preferred when diagnosing significant antemortem elevations.\"},{\"question\":\"What did the 1,000-case review find about the relationship between peripheral and vitreous glucose?\",\"answer\":\"Among 1,000 cases with serum and vitreous glucose testing, 102 non-diabetics showed peripheral glucose \\u003e500 mg/dl while vitreous glucose was \\u003c100 mg/dl, with most linked to cardiac massage during resuscitation.\"}]","PERIPHERAL BLOOD GLUCOSE - AND CARDIOPULMONARY RESUSCITATION | PDF",1789968118,13]