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This study assessed the performance of the extended field-of-view nanoScan® PET/CT P123S system designed for rodent total-body PET. Performance metrics included resolution, noise equivalent count rate, sensitivity, and image quality using NEMA NU-4 2008 protocols, plus Derenzo phantom and linearity testing, followed by in vivo evaluations. 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EJNMMI Physics (2026) 13:2 [https://doi.org/10.1186/s40658-025-00817-5](https://doi.org/10.1186/s40658-025-00817-5)  \nEJNMMI Physics  \nORIGINAL RESEARCH Open Access  \nPerformance evaluation of the nanoScan® P123S total-body PET  \nDániel Réti 1,2*, Carlos-Alcaide Corral2,3, Islay Cranston2,3, Victoria J. M. Reid2,3, Kerry M. O’Rourke2,3, Timaeus E. F. Morgan2,3, Axel Montagne4,5, Maurits A. Jansen6, Valeria K. Burianova7, Andrew Sutherland7, Péter Major1, Kálmán Nagy1, Gergő Bagaméry1 and Adriana A. S. Tavares2,3  \n*Correspondence: Dániel Réti[s2455329@ed.ac.uk](s2455329@ed.ac.uk)  \n1Mediso Ltd, Laborc Utca 3, Budapest 1037, Hungary  \n2Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK 3Edinburgh Imaging, University of Edinburgh, Edinburgh EH16 4TJ, UK 4Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4SB, UK  \n5Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK 6Department of Radiology and Medical Imaging, School of Medicine, University of Virginia, Charlottesville, Virginia 22903, USA 7School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK  \nAbstract  \nPurpose Before utilising preclinical Position Emission Tomography (PET) systems for biological studies, evaluating their performance is important to better qualify the scanner’s applications. This study aims to assess the performance of the new extended field of view (FOV) nanoScan® PET/CT P123S system, developed for rodent total-body PET applications.  \nMethods Scanner resolution, noise equivalent count rate (NECR), sensitivity and image quality were evaluated following NEMA NU-4 2008 protocols. Furthermore, a Derenzo phantom and linearity measurements were conducted. In vivo studies were subsequently carried out to evaluate system performance in biological applications. Results The scanner spatial resolution according to the NEMA protocol was 1.4 mm using FBP reconstruction, while with iterative reconstruction it was under 0.7 mm. The NECR peak using a 250‒750 keV energy window was 1805.0 kcps at 93.7 MBq and 880.7 kcps at 88.4 MBq for the mouse-sized and rat-sized phantom respectively. The absolute sensitivity was 10. 5% . The standard deviation of the uniform area of the image quality phantom was 1. 8%, while the recovery coefficients varied between 0.23 and 1.00. The spill-over ratios were 0 . 04, and 0.04 in the water and air-filled chambers respectively. Quantitative bias was \u003C 4% with a linear response up to 105 MBq. Total-body rat images were successfully acquired using the new system.  \nConclusion The new extended FOV PET system has improved sensitivity and  \ncount rate performance compared with previous systems. Its spatial resolution and quantitative accuracy are well-suited for preclinical PET applications. The extended FOV enables total-body imaging of both mice and rats.  \nKeywords PET/CT, Total-body, Instrumentation, NEMA, Performance  \nIntroduction  \nTotal-body Positron Emission Tomography (PET) imaging is an emerging technique in which the entire body of the subject remains within the field of view throughout the scanning session. By capturing tracer kinetics across the entire body in a single acquisition, total-body PET enables shorter scanning durations, improved temporal resolution,  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory reg","cbCaihoAYIPz6Y7B","https://ap.wps.com/l/cbCaihoAYIPz6Y7B","pdf",5254782,15,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the study’s goal for the nanoScan® PET/CT P123S system?\",\"answer\":\"To assess the performance of the extended field-of-view nanoScan® PET/CT P123S system developed for rodent total-body PET applications.\"},{\"question\":\"Which NEMA protocol and additional tests were used to evaluate the scanner?\",\"answer\":\"Scanner resolution, NECR, sensitivity, and image quality were assessed using NEMA NU-4 2008, with Derenzo phantom and linearity measurements added.\"},{\"question\":\"What performance improvements were reported in the results?\",\"answer\":\"The system showed improved sensitivity and count-rate performance, with spatial resolution and quantitative accuracy suitable for preclinical PET, and it enabled total-body imaging of mice and rats.\"}]","Performance evaluation of the nanoScan® P123S total-body PET | PDF",1790751654,38]