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Traditionally, splenectomy has been the first-line approach, though non-surgical treatments have been reported. The paper presents a 57-year-old patient with splenic metastasis from ovarian cancer treated successfully with percutaneous radiofrequency ablation, and includes a systematic literature review of thermal ablation cases for splenic metastases.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/percutaneous-radiofrequency-ablation-of-ovarian-cancer-metastasis-in-the-spleen-a-therapeutic-option-to-consider/340782/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/percutaneous-radiofrequency-ablation-of-ovarian-cancer-metastasis-in-the-spleen-a-therapeutic-option-to-consider/340782.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is splenic metastasis clinically challenging?","Question",{"text":112,"@type":113},"Splenic metastasis is rare, occurring in less than 1% of metastatic cancers, and it usually appears in disseminated disease, which complicates management decisions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the standard first-line therapy mentioned for splenic metastasis?",{"text":117,"@type":113},"The paper states that splenectomy has been traditionally used as the first-line therapy for splenic metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment was used in the reported ovarian cancer case?",{"text":121,"@type":113},"The patient with splenic metastasis from ovarian cancer was treated successfully with percutaneous radiofrequency ablation (RFA).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340782,1790217537,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Journal of Ultrasound (2025) 28:183–186  \n[https://doi.org/10.1007/s40477-024-00921-9](https://doi.org/10.1007/s40477-024-00921-9)  \nPercutaneous radiofrequency ablation of ovarian cancer metastasis in the spleen: a therapeutic option to consider  \nAndrea Boccatonda1 · Paula Antonia Mauloni2 · Monica Cevenini2 · Livia Masi2 · Sofia Maria Bakken2 · Carla Serra2  \nReceived: 4 February 2024 / Accepted: 13 May 2024 / Published online: 20 June 2024 © The Author(s) 2024  \nAbstract  \nSplenic metastasis are rare clinical entities developing in less than 1% of all metastatic cancers and usually in the setting of disseminated disease. To date, splenectomy is traditionally the first line therapy in patient with splenic metastasis, however non-surgical therapies have been reported. Here we described the case of a 57-year-old patient with splenic metastasis from ovarian cancer successfully treated by percutaneous radiofrequency ablation. Furthermore, we performed a literature systematic review of the cases of splenic metastases treated by thermal ablation.  \nKeywords Radiofrequency ablation · Thermal ablation · Metastasis · Ovarian cancer · Spleen  \nIntroduction  \nIn solid organ tumors, the splenic localization of a metastasis is rare and represents less than 1% of all types of metastasis. Breast, lung, colorectal and ovarian cancers and melanoma represent the most common primary origins for splenic metastasis and splenic involvement frequently characterizes the late stages of a multi-visceral metastatic process [1] . Nowadays, the treatment of splenic metastasis has been reserved to isolated ones, and the splenectomy is the firstline choice for treating an isolated splenic metastasis. However, in last years, the literature reported that 25–50% of the spleen parenchyma has to be preserved in order to prevent serious infectious. Indeed, several data have shown that the death rate from all type of infections after splenectomy is up to 600 times greater than in the general population. Therefore, the setup of safe and effective minimally invasive techniques to treat spleen focal lesions is needed [2] .  \n* Carla Serra [carla.serra@aosp.bo.it](carla.serra@aosp.bo.it)  \n1 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy  \n2 Interventional Diagnostic and Therapeutical Ultrasound Unit, Department of Organ Failure and Transplantation S, Orsola-Malpighi Hospital-University of Bologna, Via Massarenti N 9, 40138 Bologna, BO, Italy  \nRecently, thermal ablation (TA) techniques found a wide application in the treatment of solid tumors of various organs, in particular the liver and the kidneys [3] .  \nThe TA of the spleen has not been widely described; the treatment of cirrhosis and thalassemia related hypersplenism and hemostasis in trauma and in partial splenectomies are its main indications [4] . Few data about local control ofsplenic metastatic lesions have also been reported [5] . Here we report the case of a patient with spleen metastasis from ovarian carcinoma treated with percutaneous radiofrequency ablation (RFA) .  \nCase report  \nA 57-year-old woman was referred to our Ultrasound Unit for imaging follow-up for ovarian cancer diagnosed in 2013. She had no significant disease except the ovarian cancer, and she was not on any medication. As first line treatment, she underwent a hysterectomy and bilateral salpingo-oophorectomy with omentectomy and lymphadenectomy. Adjuvant chemotherapy with taxol/carboplatin was performed. In January 2015, the patient underwent laparotomic adhesiolysis, removal of the meso-rectal metastasis, wedge resection in VII liver segment, right diaphragmatic peritonectomy and hyperthermic intraperitoneal chemotherapy due to disease progression. In March 2018 a FDG positron emission tomography/computed tomography (PET/CT) scan showed two new uptake area in the spleen, near the hilum. No other  \nlesions were found in the other solid organs. A multidisciplinary evaluation with the Oncologists wa","cbCaikAm0CF1clWW","https://ap.wps.com/l/cbCaikAm0CF1clWW","pdf",844627,"English","# Introduction\n# Case report\n## Imaging and diagnosis\n## Treatment planning and procedure\n## Follow-up and results","[{\"question\":\"Why is splenic metastasis clinically challenging?\",\"answer\":\"Splenic metastasis is rare, occurring in less than 1% of metastatic cancers, and it usually appears in disseminated disease, which complicates management decisions.\"},{\"question\":\"What is the standard first-line therapy mentioned for splenic metastasis?\",\"answer\":\"The paper states that splenectomy has been traditionally used as the first-line therapy for splenic metastasis.\"},{\"question\":\"What treatment was used in the reported ovarian cancer case?\",\"answer\":\"The patient with splenic metastasis from ovarian cancer was treated successfully with percutaneous radiofrequency ablation (RFA).\"}]","Percutaneous radiofrequency ablation of ovarian cancer metastasis in the spleen - a therapeutic option to consider | PDF",1790038876]