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It examines the context in which medications may become inappropriate when harms outweigh benefits, noting that while stopping potentially inappropriate drugs can improve outcomes, implementation remains inconsistent. Using qualitative semi-structured interviews in the Netherlands and inductive thematic analysis, the research identifies three themes: facilitating well-being, preventing harm, and managing uncertainty.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/perceptions-of-deprescribing-for-patients-with-limited-life-expectancy-in-primary-care/458270/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/perceptions-of-deprescribing-for-patients-with-limited-life-expectancy-in-primary-care/458270.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study aim to understand about deprescribing in primary care?","Question",{"text":112,"@type":113},"The study aims to understand perceptions of deprescribing for patients with limited life expectancy in primary care.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the study results derived?",{"text":117,"@type":113},"A qualitative interview study was conducted in primary care in the Netherlands and analyzed using inductive thematic analysis.",{"name":119,"@type":110,"acceptedAnswer":120},"Which themes emerged from the interviews?",{"text":121,"@type":113},"Three key themes emerged: facilitating well-being, preventing harm, and dealing with uncertainty.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},458270,1791187275,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","Primary Health Care Research & Development  \n[cambridge.org/phc](cambridge.org/phc)  \nResearch  \nCite this article: van Aken ECM, van der Waal MS, Teunissen SCCM, Uyttewaal AG, Verboeket-Crul C, Smits-Pelser H,  \nGeijteman ECT, Grant MP. (2026) Perceptions of deprescribing for patients with limited life expectancy in primary care. Primary Health Care Research & Development 27(e2): 1–7.  \ndoi: 10. 1017/S1463423625100686  \nReceived: 21 April 2024  \nRevised: 28 November 2024  \nAccepted: 7 December 2024  \nKeywords:  \ndeprescribing; end-of-life care; interview study; perceptions; primary care  \nCorresponding author:  \nEmma C. M. van Aken;  \nEmail: [e.c. m.vanaken@outlook.com](e.c. m.vanaken@outlook.com)  \n© The Author(s), 2026 . Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/4.0/](creativecommons.org/licenses/by/4.0/)), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.  \nPerceptions of deprescribing for patients with limited life expectancy in primary care  \nEmma C. M. van Aken1 , Maike S. van der Waal1 , Saskia C.C. M. Teunissen1 , Allegonda G. Uyttewaal2, Cathelijne Verboeket-Crul2, Hanneke Smits-Pelser3, Eric C.T. Geijteman4 and Matthew P. Grant 1   \n1Center of Expertise in Palliative Care, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Department of General Practice, Utrecht, The Netherlands; 2Academic Hospice Demeter, De Bilt, The Netherlands; 3Leidsche Rijn Julius Healthcare Center, Parkwijk, Utrecht, The Netherlands and 4Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands  \nAbstract  \nAim: The study aims to understand the perceptions ofdeprescribing in primary care for patients with a limited life expectancy. Background: In the setting of limited life expectancy, medications may become inappropriate when the possible harms of use outweigh the benefits. Whilst the cessation of potentially inappropriate medications is associated with improved patient outcomes, incorporating this process into routine primary care is poorly enacted. Methods: Qualitative interview study performed in primary care settings in the Netherlands, including primary care health professionals, patients with limited life expectancy, and their caregivers. Semi-structured interviews were conducted and analysed using inductive thematic analysis. Findings: Three key themes emerged: (1) facilitating well-being,(2) preventing harm, and (3) dealing with uncertainty. A key goal of mediation use is to facilitate well-being, although the perceptions of this effect may not always match the reality due to changed clinical circumstances. The decision to continue or stop medication is influenced by the wish to prevent harm and to what extent participants find ways to deal with the uncertainties facing them.  \nReluctance to deprescribe medications is often related to uncertainties around ceasing medications, lack of clear clinical guidance, and the evolving situation of advanced illness. Integrating these discussions into routine primary care for patients with chronic and incurable illnesses may assist patients and healthcare professionals to address issues around medication use in a proactive manner and promote advance care planning discussions.  \nIntroduction  \nPatients in the last year of life use an average of 10 medications, with 80% of these patients using at least one potentially inappropriate medication (Arevalo et al., 2018; Pype et al., 2018; Antonisse etal., 2023). Almost 30% of the patients are prescribed a preventive medication on the day of death (Arevalo etal., 2018) . Given the short life expectancy and vulnerability of patients atthe end of life, the limited benefits and increased harms of these medications should be carefully considered. Pol","cbCaimDNSmYWfw3S","https://ap.wps.com/l/cbCaimDNSmYWfw3S","pdf",264270,"English","# Abstract\n# Introduction\n## Medication burden and potential inappropriateness\n## Rationale for deprescribing\n## Challenges for routine primary care integration","[{\"question\":\"What does the study aim to understand about deprescribing in primary care?\",\"answer\":\"The study aims to understand perceptions of deprescribing for patients with limited life expectancy in primary care.\"},{\"question\":\"How were the study results derived?\",\"answer\":\"A qualitative interview study was conducted in primary care in the Netherlands and analyzed using inductive thematic analysis.\"},{\"question\":\"Which themes emerged from the interviews?\",\"answer\":\"Three key themes emerged: facilitating well-being, preventing harm, and dealing with uncertainty.\"}]","Perceptions of deprescribing for patients with limited life expectancy in primary care | PDF",1790752410,18]