[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331414-105":59,"doc-detail-331414-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","per3-promoter-hypermethylation-correlates-to-the-progression-of-pan-cancer","PER3 promoter hypermethylation correlates to the progression of pan-cancer","","Research in Clinical Epigenetics investigates how reduced Period circadian regulator 3 (PER3) expression varies across cancers and how PER3 contributes to tumor progression. Integrating multiple public databases, bioinformatics analyses, and in vitro/in vivo validation, the study links PER3 downregulation to poor outcomes in eight cancer types and identifies increased promoter methylation in eleven. Promoter hypermethylation correlates with decreased PER3 expression in six cancers, with cg12258811 associated with advanced stages and worse survival.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/per3-promoter-hypermethylation-correlates-to-the-progression-of-pan-cancer/331414/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/per3-promoter-hypermethylation-correlates-to-the-progression-of-pan-cancer/331414.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What drives reduced PER3 expression in cancers according to the study?","Question",{"text":112,"@type":113},"The study reports increased PER3 promoter methylation across multiple cancer types, which correlates with decreased PER3 expression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cancers show a link between PER3 promoter hypermethylation and reduced PER3 expression?",{"text":117,"@type":113},"Promoter hypermethylation correlates with decreased PER3 expression in six cancers: breast invasive carcinoma, colon adenocarcinoma, head and neck squamous cell carcinoma, kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), and uterine corpus endometrial carcinoma.",{"name":119,"@type":110,"acceptedAnswer":120},"How does decitabine affect PER3 and tumor cell functions in the experiments?",{"text":121,"@type":113},"Decitabine enhances PER3 expression and inhibits KIRP cell functions by reducing methylation at the PER3 promoter (cg12258811).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331414,1790193138,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Li et al. Clinical Epigenetics (2024) 16:140 [https://doi.org/10.1186/s13148-024-01760-5](https://doi.org/10.1186/s13148-024-01760-5)  \nClinical Epigenetics  \n RESEARCH Open Access  \nPER3 promoter hypermethylation correlates to the progression of pan-cancer  \nYaoxu Li1,2†, Wenjuan Li3†, Jinhai Deng2 and Mingzhu Yin2,4,5*  \nAbstract  \nBackground Malignant cells exhibit reduced period circadian regulator 3 (PER3) expression. However, the underlying mechanisms of variations in PER3 expression in cancers and the specific function of PER3 in tumor progression remain poorly understood.  \nResults We explored multiple public databases, conducted bioinformatics analyses, and performed in vitro  \nand in vivo experiments for validation. We found PER3 expression was decreased in most types of cancers, and PER3 downregulation was associated with a poor prognosis in 8 types of cancer. PER3 promoter methylation levels were increased in 11 types of cancer. Promoter hypermethylation (CpG islands [CGIs] cg12258811 and cg14204433) correlated with decreased PER3 expression in six cancers (breast invasive carcinoma, colon adenocarcinoma, head and neck squamous cell carcinoma, kidney renal papillary cell carcinoma [KIRP], lung adenocarcinoma [LUAD], and uterine corpus endometrial carcinoma) . CGI cg12258811 hypermethylation was associated with reduced survival time and advanced cancer stages. Moreover, the bisulfite pyrosequencing assay confirmed CGI cg12258811 hypermethylation and its negative correlation with PER3 expression. In vitro and in vivo experiments demonstrated that PER3 inhibited KIRP and LUAD progression. Decitabine enhanced PER3 expression and inhibited KIRP cell functions by reducing promoter (cg12258811) methylation level.  \nConclusions Our findings advanced the mechanistic understanding of variations in PER3 expression in cancersand confirmed the tumor-associated function of PER3 hypermethylation and downregulation.  \nKeywords Period circadian regulator 3, Promoter, Methylation, Pan-cancer, Kidney renal papillary cell carcinoma, Lung adenocarcinoma  \n†Yaoxu Li, and Wenjuan Li have contributed equally.  \n*Correspondence:  \nMingzhuYin [yinmingzhu2008@126.com](yinmingzhu2008@126.com)  \n1 Department of Stomatology, Chongqing University Three Gorges Hospital, School of Medicine, Chongqing University, Wanzhou District, Chongqing 404100, China  \n2 Clinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, School of Medicine, Chongqing University, Wanzhou District, Chongqing 404100, China  \n3 Department of Emergency and Critical Care Medicine, The First Afliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China  \n4 Chongqing Technical Innovation Center for Quality Evaluation and Identification of Authentic Medicinal Herbs, Wanzhou District, Chongqing 404100, China  \n5 Three Gorges Hospital & Academy for Advanced Interdisciplinary Technology, CQU-Ferenc Krausz Nobel Laureate Scientific Workstation, Chongqing University, Chongqing, China  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted ","cbCaidVjPh18IllR","https://ap.wps.com/l/cbCaidVjPh18IllR","pdf",12967912,17,"English","# Abstract\n## Background\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What drives reduced PER3 expression in cancers according to the study?\",\"answer\":\"The study reports increased PER3 promoter methylation across multiple cancer types, which correlates with decreased PER3 expression.\"},{\"question\":\"Which cancers show a link between PER3 promoter hypermethylation and reduced PER3 expression?\",\"answer\":\"Promoter hypermethylation correlates with decreased PER3 expression in six cancers: breast invasive carcinoma, colon adenocarcinoma, head and neck squamous cell carcinoma, kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), and uterine corpus endometrial carcinoma.\"},{\"question\":\"How does decitabine affect PER3 and tumor cell functions in the experiments?\",\"answer\":\"Decitabine enhances PER3 expression and inhibits KIRP cell functions by reducing methylation at the PER3 promoter (cg12258811).\"}]","PER3 promoter hypermethylation correlates to the progression of pan-cancer | PDF",1789993186,43]