[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328283-105":59,"doc-detail-328283-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","peptide-conjugated-boron-neutron-capture-therapy-review","Peptide Conjugated Boron Neutron Capture Therapy - Review","","Boron neutron capture therapy (BNCT) is presented as a non-invasive cancer treatment that removes tumor cells while limiting injury to healthy tissue. The approach relies on low-energy thermal neutrons and boron-10 uptake by cancer cells, where nuclear reactions generate alpha particles and recoiling lithium-7 nuclei that induce cell death. Clinical progress is acknowledged, yet tumor selectivity and boron loading remain constrained. This review focuses on developing peptide-conjugated delivery strategies to improve selectivity and boron content.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/peptide-conjugated-boron-neutron-capture-therapy-review/328283/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/peptide-conjugated-boron-neutron-capture-therapy-review/328283.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is boron neutron capture therapy (BNCT) and how does it kill cancer cells?","Question",{"text":112,"@type":113},"BNCT exposes cancer cells to low-energy thermal neutrons, where boron-10 uptake triggers a nuclear reaction. 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Sainaga Jyothi1, Nagavendra Kommineni2􀀍  \n1. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38163, USA.  \n2. Center for Biomedical Research, Population Council, New York, NY 10065, USA.  \n􀀍 Corresponding author: Dr. Nagavendra Kommineni, [nkommineni@popcouncil.org](nkommineni@popcouncil.org).  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2024.02.11; Accepted: 2024.05.14; Published: 2024.05.28  \nAbstract  \nA cutting-edge non-invasive cancer treatment method called boron neutron capture therapy (BNCT) allows for the removal of cancerous tumor cells with the least possible damage to healthy tissue. It involves the exposure of cancer cells with low-energy thermal neutrons, boron-10 (10B) cellular uptake causes cancer cell death by producing alpha particles and recoiling lithium-7 (7 Li) nuclei. Despite positive outcomes from clinical trials conducted all around the world, these substances have relatively limited tumor selectivity or low boron content per molecule. The development of new boron delivery agents with more selectivity and enhanced boron loading would advance this technique and promote its use in clinics as a primary cancer treatment. As peptide-binding cell surface receptors are typically overexpressed on cancer cells, they can be seen as interesting targets for targeted tumor therapy. The attachment of meta-carboranes to peptide conjugates that target tumor cells specifically by their overexpressed receptors may be a method to get around these problems. A state-of-the-art overview of current developments in the application of BNCT for cancer targeted therapy via peptide conjugation is the goal of this review.  \nKeywords: BNCT, Peptide conjugation, Tumor targeting, targeting peptides and BNCT designing  \nIntroduction  \nPeptide conjugated boron neutron capture therapy (BNCT) is a type of cancer treatment that combines two elements: boron and neutron radiation. Boron is a non-toxic element that can be selectively taken up by cancer cells when delivered in the form of a boron-containing compound [1] . Neutron radiation, on the other hand, can be used to trigger a nuclear reaction in boron atoms, releasing high-energy particles that can kill cancer cells [2] . Peptide conjugated BNCT takes advantage of the fact that certain peptides can bind specifically to proteins that are overexpressed on the surface of cancer cells, such as receptors or transporters [3] . By attaching boron-containing compounds to these peptides, it is possible to selectively deliver boron to cancer cells while sparing healthy tissue [4] . The peptide conjugated BNCT process involves several steps. First, a boron-containing compound is conjugated to a  \ntargeting peptide. The resulting peptide-boron conjugate is then administered to the patient, where it circulates in the blood stream and selectively binds to cancer cells. Once the conjugate has accumulated in the tumor, the patient is exposed to a beam of neutrons, which causes boron atoms in the conjugate to undergo a nuclear reaction and release high-energy particles that kill nearby cancer cells [5–8] .  \nPeptide conjugated BNCT has several potential advantages over other cancer treatments [9] . It is highly specific, meaning that it can target cancer cells while sparing healthy tissue. It is also a non-invasive procedure, which means that it does not require surgery [10] . Additionally, because boron compounds are not toxic at low ","cbCaii58c2MRfF3m","https://ap.wps.com/l/cbCaii58c2MRfF3m","pdf",3012764,15,"English","# Abstract\n# Keywords\n# Introduction\n# Principles and BNCT’s basic requirements","[{\"question\":\"What is boron neutron capture therapy (BNCT) and how does it kill cancer cells?\",\"answer\":\"BNCT exposes cancer cells to low-energy thermal neutrons, where boron-10 uptake triggers a nuclear reaction. This releases alpha particles and recoiling lithium-7 nuclei that destroy cells that have taken up the boron compounds.\"},{\"question\":\"Why is peptide conjugation used in BNCT?\",\"answer\":\"Peptide conjugation exploits the overexpression of specific receptors or transporters on cancer cell surfaces. By attaching boron-containing compounds to targeting peptides, boron can be selectively delivered to cancer cells while sparing healthy tissue.\"},{\"question\":\"What basic requirements and principles must BNCT satisfy?\",\"answer\":\"BNCT is described as a two-step radiotherapy: target the tumor with non-radioactive boron (10B), then expose it to low-energy neutrons. Effective therapy depends on the boron agent’s suitability (including low toxicity) and the timing/concentration conditions, along with controlled neutron-beam focus to limit damage to normal tissues.\"}]","Peptide Conjugated Boron Neutron Capture Therapy - Review | PDF",1789979171,38]