[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-381176-105":59,"doc-detail-381176-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","penile-metastasis-secondary-to-urothelial-bladder-cancer","Penile metastasis secondary to urothelial bladder cancer","","Penile metastasis is exceptionally rare, and most cases arise from bladder or prostate cancer, typically presenting with initial penile symptoms that later reveal disseminated disease and a worsened prognosis. A case report describes an 80-year-old patient accidentally diagnosed with metastatic high-grade urothelial cancer during male circumcision. Subsequent workup confirmed disseminated neoplastic disease, with whole-body CT frequently identifying metastatic spread. The document discusses clinical features, diagnostic findings, and outcome.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/penile-metastasis-secondary-to-urothelial-bladder-cancer/381176/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/penile-metastasis-secondary-to-urothelial-bladder-cancer/381176.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is penile metastasis considered extremely rare and what cancers most commonly cause it?","Question",{"text":113,"@type":114},"Penile metastasis is extremely rare despite rich vascularization and an extensive lymphatic network. The most common primary neoplasms are bladder and prostate cancer.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the presented patient incidentally diagnosed?",{"text":118,"@type":114},"The 80-year-old patient was evaluated for phimosis and underwent circumcision. Redness after exposure of the glans led to dermoscopic assessment and biopsy, revealing high-grade invasive urothelial cancer.",{"name":120,"@type":111,"acceptedAnswer":121},"What additional findings were detected after penile metastasis was suspected?",{"text":122,"@type":114},"Thoracic and abdominal CT demonstrated metastases in the liver and lungs and an ambiguous lesion in the left adrenal gland, supporting disseminated disease.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},381176,1790716926,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":39},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","Urology Case Reports 49 (2023) 102428  \nContents lists available at ScienceDirect Urology Case Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/eucr)[ www.elsevier.com/locate/eucr](homepage: www.elsevier.com/locate/eucr)  \n| Oncology\u003Cbr>Penile metastasis secondary to urothelial bladder cancer\u003Cbr>Maciej Dolnyb, *, Mateusz Czajkowskia, Katarzyna Czajkowskac, Małgorzata Sokołowska-Wojdyłoc, Marcin Matuszewskia\u003Cbr>a Department of Urology, Medical University of Gdan´sk, Gdan´sk, Poland\u003Cbr>b Student Research Group at the Department of Urology, Medical University of Gda´nsk, Gda´nsk, Poland c Department of Dermatology, Venerology and Allergology, Medical University of Gda´nsk, Gda´nsk, Poland |  |  | |\n| --- | --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |  |\n| Keywords: Penile cancer Metastases Bladder cancer |  | Penile metastasis is extremely rare. The most common neoplasms that spread to the external male genital area are bladder and prostate cancer. The diagnosis usually begins with the appearance of penile symptoms. Further examination usually reveals metastasis to other organs, which worsens the patient prognosis.\u003Cbr>We present a case report of an 80-year-old patient who was accidently diagnosed with metastatic high-grade urothelial cancer during a male circumcision. Further diagnostic process revealed a disseminated neoplastic disease.\u003Cbr>Whole-body computed tomography (CT) scan often reveals disseminated neoplastic disease, which is the cause of high mortality in secondary penile neoplasms. |  |\n\n1. Introduction  \nPenile metastasis is extremely rare, despite rich vascularization and an extensive lymphatic network in the male external genital area. To date, there have only been 460 case reports of such ailments. The most frequent primary sites of penile metastasis are the bladder, prostate, rectum, kidney, testis, and lungs.1 The mechanism of metastasis remains unknown, but there are suggestions for direct extension or lymphatic, arterial, and venous retrograde spread. The most common clinical manifestations of penile metastasis are penile swelling, nodules, ulceration, hematuria, malignant priapism, and penile or perineal pain.2 Generally, in bladder cancer, there is an interval of up to several years between primary diagnosis and secondary to penile metastasis.3 Penile metastasis is usually a sign of disseminated disease and poor prognosis. Most patients require a multidisciplinary approach, despite survival at approximately 12 months after diagnosis.4 We present a case of incidentally diagnosed penile metastasis secondary to bladder cancer during circumcision surgery due to phimosis.  \n2. Case presentation  \nThe 80-year-old male patient was admitted to the tertiary referral Department of Urology with phimosis. An unretractable foreskin was observed two years prior to admission. The patient had undergone  \ncystoprostatectomy 15 years earlier with the emergence of a neobladder with the Studer method due to high-grade urothelial cancer with the staging of pT2N0Mx. Fifteen years between cystoprostatectomy and admission to the Department of Urology were uneventful, during which time the patient remained under clinical surveillance at the abovementioned tertiary hospital. Moreover, a DDD pacemaker was implanted in a patient with hypertension and cardiac arrhythmia.  \nThe patient qualified for circumcision in a tertiary hospital because of ongoing surveillance. Redness was observed after the penile glans were exposed during the surgery. Intraoperative dermoscopy revealed areas of polymorphic vessels (shown in Fig. 1). It was decided to take a biopsy of the suspicious lesions. The foreskin was then removed using the sleeve circumcision technique. The patient’s postoperative period was uneventful.  \nHistopathological examination revealed lichen sclerosus and highgrade invasive urothelial cancer with p63 (+), uroplakin (+/-) (shown in Fig. 2), and GATA3 (+) staining (shown in Fig. 3).  \nMetastasis of","cbCaimUsn3UNNIZC","https://ap.wps.com/l/cbCaimUsn3UNNIZC","pdf",2353007,"English","# Introduction\n# Case presentation\n# Discussion","[{\"question\":\"Why is penile metastasis considered extremely rare and what cancers most commonly cause it?\",\"answer\":\"Penile metastasis is extremely rare despite rich vascularization and an extensive lymphatic network. The most common primary neoplasms are bladder and prostate cancer.\"},{\"question\":\"How was the presented patient incidentally diagnosed?\",\"answer\":\"The 80-year-old patient was evaluated for phimosis and underwent circumcision. Redness after exposure of the glans led to dermoscopic assessment and biopsy, revealing high-grade invasive urothelial cancer.\"},{\"question\":\"What additional findings were detected after penile metastasis was suspected?\",\"answer\":\"Thoracic and abdominal CT demonstrated metastases in the liver and lungs and an ambiguous lesion in the left adrenal gland, supporting disseminated disease.\"}]","Penile metastasis secondary to urothelial bladder cancer | PDF",1790243967]