[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-152614-en":3,"doc-seo-152614-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},152614,1099513958762,"Logic","https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253",7,"Healthcare","Pediatric Ischemic Stroke - Review Article","Pediatric cerebrovascular disease is a leading cause of death and disability, and children who survive ischemic stroke often face long-lasting sequelae that disrupt school reentry and later independence. Because childhood stroke is rare and front-line clinicians may be less familiar with its presentation, risk factors, and care pathways, the article reviews pediatric ischemic stroke across risk factors, acute management, and sequelae. It summarizes current reperfusion evidence gaps, discusses thrombolysis and thrombectomy considerations, and outlines regional preparedness for rapid pediatric triage and treatment.","REVIEW ARTICLE  \n􀀁  \nCONTINUUM AUDIO INTERVIEW AVAILABLE ONLINE  \nCITE AS:  \nCONTINUUM (MIN NEA P M INN) 2023;29(2, CEREBROVASCULAR DISEASE):566–583.  \nAddress correspondence to Dr Christine Fox, Sandler Neurosciences Center, University of California San Francisco, 675 Nelson Rising Ln, 3rd Floor, San Francisco, CA 94143, [christine.fox@ucsf.edu](christine.fox@ucsf.edu).  \nRELATIONSHIP DISCLOSURE: The institution of Dr Fox has received personal compensation in the range of $500 to $4999 for serving as a consultant for Competitive Drug Development International Ltd, research support from the American Heart Association/ Bugher Foundation, and the National Institutes of Health/  \nNational Institute of Neurological Disorders and Stroke, and has received publishing royalties from a publication relating to health care.  \nUNLABELED USE OF PRODUCTS/INVESTIGATIONAL USE DISCLOSURE:  \nDr Fox discusses the use of thrombolysis and thrombectomy for the treatment of stroke in children.  \n© 2023 American Academy of Neurology.  \nPediatric Ischemic Stroke  \nBy Christine Fox, MD, MAS  \nABSTRACT  \nOBJECTIVE: Pediatric cerebrovascular disease is one of the leading causes of death and disability in children. Survivors of childhood stroke and their families are often left to cope with long-lasting sequelae, such as barriers to school reentry and long-term challenges in attaining independence as adults. Because childhood stroke is rare and providers may not be familiar with the disorder, this article reviews the risk factors, acute management, and sequelae of ischemic stroke in children.  \nLATEST DEVELOPMENTS: High-quality evidence has resulted in an organized approach to emergent treatment of ischemic stroke in adults, but most front-line providers are less prepared for emergent stroke management in children. The level of evidence for reperfusion therapies in children remains low but is growing. Thrombolysis and thrombectomy are sometimes considered for hyperacute treatment of stroke in children. Readiness for pediatric stroke at regional centers should include an organized approach to pediatric stroke triage and management based on extrapolation from adult stroke trials, expert consensus, and emerging pediatric studies.  \nESSENTIAL POINTS:This review provides up-to-date information about ischemic stroke risk factors and management in children. Preparation for rapid stroke diagnosis and management in children may improve outcomes.  \nINTRODUCTION  \nS  \ntroke is uncommon in children but can be a major cause of childhood mortality and morbidity when it occurs. When occurring at a young age, stroke can result in long-term neurologic sequelae and disabilities over many years. Both acute and chronic care for a child with stroke are costly. The lifetime costs for care of a child who had a stroke are  \ngenerally higher than the costs of similar types of strokes in adults, and the economic burden for society is sustained over a longer period of time.1 Adjusting to new disabilities from a stroke can be difficult for children and their families. Beyond physical health, the toll on mental and emotional health is often high forchildren and caregivers. For these reasons, effective stroke treatments to improve neurologic outcomes for children are essential.  \nBy convention, a stroke that occurs in children after the first 28 days of life is considered a childhood stroke. A stroke that occurs during the first 28 days of life is considered a perinatal stroke. Perinatal arterial ischemic stroke occurs in approximately one in 3000 live full-term births,2 which makes the weeks around birth one of the highest-risk time periods for stroke to occur. The term presumed perinatal stroke is used when imaging demonstrates a chronic infarct in an older  \n566 APRIL 2023  \nCopyright © American Academy of Neurology. Unauthorized reproduction of this article is prohibited.  \nchild who begins to show focal deficits during development. Childhood and perinatal strokes are categorized ","cbCaiuR6EsYw6t60","https://ap.wps.com/l/cbCaiuR6EsYw6t60","pdf",4723779,1,18,"English","en",105,"# Abstract\n# Introduction\n# Hyperacute Treatment for Pediatric Stroke","[{\"question\":\"Why is pediatric ischemic stroke clinically important for outcomes and long-term care?\",\"answer\":\"It is a leading cause of death and disability, and survivors often develop long-lasting neurologic sequelae that hinder school reentry and long-term independence.\"},{\"question\":\"What challenges make pediatric stroke diagnosis difficult in the first hours?\",\"answer\":\"Symptoms may start with stuttering onset, headache, or acute symptomatic seizures, and early signs are frequently mistaken for seizure, migraine, infection, demyelinating disease, or other stroke mimics.\"},{\"question\":\"How do reperfusion therapy options in children compare with adults?\",\"answer\":\"High-quality adult evidence supports organized emergent treatment, while reperfusion evidence in children remains lower but is growing; thrombolysis and thrombectomy may be considered for hyperacute treatment in selected cases.\"}]","Pediatric Ischemic Stroke - Review Article | PDF",1787864622,45,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"pediatric-ischemic-stroke-review-article","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/pediatric-ischemic-stroke-review-article/152614/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-09-06","2026-08-27",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"Why is pediatric ischemic stroke clinically important for outcomes and long-term care?","Question",{"text":76,"@type":77},"It is a leading cause of death and disability, and survivors often develop long-lasting neurologic sequelae that hinder school reentry and long-term independence.","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"What challenges make pediatric stroke diagnosis difficult in the first hours?",{"text":81,"@type":77},"Symptoms may start with stuttering onset, headache, or acute symptomatic seizures, and early signs are frequently mistaken for seizure, migraine, infection, demyelinating disease, or other stroke mimics.",{"name":83,"@type":74,"acceptedAnswer":84},"How do reperfusion therapy options in children compare with adults?",{"text":85,"@type":77},"High-quality adult evidence supports organized emergent treatment, while reperfusion evidence in children remains lower but is growing; 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