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The review covered commonly used procedures (vulvovaginoplasty and mastectomy) and synthesized final perceptions from comprehensive management approaches. Outcomes were organized across aesthetics, satisfaction, complications, and mental health, using a rapid umbrella review approach across literature from 1988 to 2024.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pd42-systematic-review-of-the-comprehensive-approach-to-gender-reassignment-surgery-summary/445680/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pd42-systematic-review-of-the-comprehensive-approach-to-gender-reassignment-surgery-summary/445680.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the PD42 review address?","Question",{"text":112,"@type":113},"Access to gender reassignment surgery as an isolated service is limited by shortages of trained professionals, lack of protocols, and economic and geographic barriers, affecting clinical and satisfaction outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which procedures and population were included in the review?",{"text":117,"@type":113},"The review considered procedures prevalent in Argentina—vulvovaginoplasty and mastectomy—and included transgender people older than 16 years.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the evidence suggest about integrated and comprehensive care models?",{"text":121,"@type":113},"Findings showed divergence between comprehensive integrated models and the evidence base, with complication and satisfaction data predominating and few studies framing results within integrated models.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},445680,1791036500,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81,"preview_page_count":4},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","S56 Poster Presentations (online)  \nPD41 Potential Life Lost And Indirect Costs Of Ovarian Cancer For Patients In Brazil: A RealWorld Study  \nPamela Santana ([pamela.santana@astrazeneca.com](pamela.santana@astrazeneca.com)), Eduardo Paulino and Flávia Lopes  \nIntroduction: Ovarian cancer (OC) is the most lethal gynecological tumor worldwide. This study aimed to describe the profile of patients with OC and estimate the indirect costs of OC within the Brazilian Unified Health System (SUS) .  \nMethods: This retrospective observational study used data from the Department of Informatics of the SUS and included patients aged 18 years or older with at least one record of International Classification of Diseases, 10th Revision code C56 from 2014 to 2023 . Indirect costs were estimated by calculating years of potential life lost (YPLL) based on a 2022 life expectancy of 79 years for Brazilian women. The age threshold of years of potential productivity lost (YPPLL) was set at 62 years. The cost of productivity loss (CPL) was calculated using the gross domestic product (GDP) per capita in USD from the World Bank, converted to BRL (USD1=BRL5 .66) .  \nResults: The study included a total of 36,141 patients with OC, with an average age of 56.1 years (standard deviation 13.4) at the time of their first claim. Most of the patients (51.2%) were white, lived in the southeast region of Brazil (44.6%), and had their first claim at advanced cancer stages (78.1%) . The estimated indirect costs for OC were 22.1 YPLL per patient. The estimated YPPLL was 7.3 years, and the CPL was USD65,705.30 (BRL374,040.56) per patient. Conclusions: This study provided valuable insights into the profile and indirect costs of OC. By analyzing real-world data, we highlighted the burden of OC, which impacts not only the health and longevity of patients but also places a significant financial burden on society due to productivity losses.  \nPD42 Systematic Review Of The Comprehensive Approach To Gender Reassignment Surgery  \nSantiago Torales ([santiago.torales@gmail.com](santiago.torales@gmail.com)), Darío García and Emanuel Medina  \nIntroduction: Access to gender reassignment surgery (GRS) as an isolated process would not imply achieving clinical and satisfaction results in transgender people. Public subsystems face a shortage of trained professionals, a lack of protocols, fragmented care, and economic and geographic barriers. This review sought evidence on integrated and equitable care models for access to GRS.  \nMethods: A systematic review(SR)was conducted on the effectiveness and safety of GRS prevalent in Argentina (vulvovaginoplasty [VVP] and mastectomy [MRP]) in transgender people older than 16 years. The SR also considered final perceptions from an integrated and comprehensive management approach. The Web of Science and MEDLINE databases were consulted, prioritizing clinical trials, SRs, health technology assessments, and relevant individual studies from 1988 to 2024, using a rapid umbrella review methodology. The results of the evidence were ordered by relevant outcomes (aesthetic, satisfaction, complications, mental health)within the framework ofintegrated models applicable to inclusive and equitable health policies.  \nResults: For MRP, six SRs (two specific, four general) and six cohort studies (three specific, three general) were included. For VVP, 16 SRs (nine specific, seven general) and 38 cohort studies (35 specific, three general) were included. Techniques for each surgery were described, citing results about complications (71%), quality of life (48%), mental health (16%), aesthetic aspects (58%), and satisfaction (73%), but only 0.2 percent considered them within frameworks of integrated models. With a lack of quality evidence, challenges persist in unifying classifications of outcomes over time and generalizing findings to different health systems.  \nConclusions: The recommendations of scientific societies and current legal frameworks suggest access to","cbCailYMbqfhJVYE","https://ap.wps.com/l/cbCailYMbqfhJVYE","pdf",30976,"English","# PD42 Systematic Review Of The Comprehensive Approach To Gender Reassignment Surgery\n## Introduction\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What problem does the PD42 review address?\",\"answer\":\"Access to gender reassignment surgery as an isolated service is limited by shortages of trained professionals, lack of protocols, and economic and geographic barriers, affecting clinical and satisfaction outcomes.\"},{\"question\":\"Which procedures and population were included in the review?\",\"answer\":\"The review considered procedures prevalent in Argentina—vulvovaginoplasty and mastectomy—and included transgender people older than 16 years.\"},{\"question\":\"What did the evidence suggest about integrated and comprehensive care models?\",\"answer\":\"Findings showed divergence between comprehensive integrated models and the evidence base, with complication and satisfaction data predominating and few studies framing results within integrated models.\"}]","PD42 - Systematic Review Of The Comprehensive Approach To Gender Reassignment Surgery - Summary | PDF",1790712554]