[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-459632-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-459632-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","pcornet-an-infrastructure-supporting-innovation-in-clinical-study-design","PCORnet® - An Infrastructure Supporting Innovation in Clinical Study Design","","PCORnet® is a national resource supported by the Patient-Centered Outcomes Research Institute, built to expand the capacity for efficient, patient-centered health research. The adaptable PCORnet infrastructure can be applied to multiple study designs, including PCORnet® Studies, a vetted subset that satisfies specific approval criteria and demonstrates rigorous adherence to quality and impact standards. Across 10 years, more than 300 studies were completed using PCORnet, with 58 meritorious studies, 19 already completed.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/pcornet-an-infrastructure-supporting-innovation-in-clinical-study-design/459632/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/pcornet-an-infrastructure-supporting-innovation-in-clinical-study-design/459632.png","ImageObject",300,407,{"name":42,"@type":43},"Alex Sinclair","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is PCORnet® and what is it designed to do?","Question",{"text":63,"@type":64},"PCORnet® is a national resource funded by PCORI, designed to enhance the capacity to conduct efficient, patient-centered health research.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do PCORnet® Studies differ from other research using the infrastructure?",{"text":68,"@type":64},"PCORnet® Studies are a distinguished subset that meets specific criteria and approval requirements, and they emphasize collaboration, transparency, and continuous improvement.",{"name":70,"@type":61,"acceptedAnswer":71},"What kinds of study designs and resources does PCORnet® support?",{"text":72,"@type":64},"The infrastructure supports a variety of study designs, including observational studies and prospective interventional trials, using resources such as the PCORnet Common Data Model (CDM) that harmonizes electronic health record data.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},459632,1791391538,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":107,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","EMPIRICAL PAPER  \nPCORnet® : An Infrastructure Supporting Innovation in  \nClinical Study Design  \nAdrian F. Hernandez, MD, MHS, * Elizabeth Shenkman, PhD,† Kathleen McTigue, MD,‡ Lisa Kepler, BA, * Lauren W. Cohen, MA, * Mónica Pérez Jolles, PhD,§ Russell L. Rothman, MD, MPP,‖ Jason P. Block, MD, MPH,¶ Thomas W. Carton, PhD, MS,\\# Jonathan Tobin, PhD, **‖‖ Elisa L. Priest, DrPH,†† Crystal Evans, MS,§ John Heintzman, MD,‡‡ and David A. Williams, PhD§§  \nAbstract: PCORnet®, a national resource funded by the PatientCentered Outcomes Research Institute, is designed to enhance the nation’s capacity to conduct efficient, patient-centered health research. The robust and adaptable PCORnet infrastructure can be leveraged to support a variety of study designs. Within this framework, PCORnet® Studies, a distinguished subset of research studies that meets specific criteria and approval, serve as exemplary models of patient-centered research, standing out for their rigorous adherence to criteria that elevate the quality and impact of research. Over the past 10 years, over 300 studies have been completed using the PCORnet infrastructure, including 58 studies that have earned the distinction of being a meritorious PCORnet® Study, of which 19 have been completed. We explore several of these efforts, highlighting the study archetypes supported by the PCORnet infrastructure, as well as the clinical therapeutic areas of these studies, funding sources, and breadth of PCORnet institutional users. We also  \nFrom the *Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC; †Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL; ‡Department of Medicine, University of Pittsburgh, Pittsburgh, PA; §University of Colorado School of Medicine, Aurora, CO; ‖Vanderbilt University Medical Center, Nashville, TN;¶Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA; \\#Louisiana Public Health Institute, New Orleans, LA;  \n**Clinical Directors Network (CDN), New York, NY; ‖‖The Rockefeller University, New York, NY; ††Baylor Scott & White Research Institute, Dallas, TX; ‡‡Oregon Health and Sciences University, Portland, OR; and §§University of Michigan, Ann Arbor, MI.  \nThis work is supported by PCORI Awards RI-DCRI-01-PS1, RIDCRI-01-PS3, RI-FLORIDA-01-PS1, RI-PITT-01-PS1, RI-LPHI- 01-PS1, RI-VUMC-01-PS1, RI-CORNELL-01-MC, RI-OCHIN-01-PS1 .  \nThe authors declare no conflict of interest.  \nCorrespondence to: Lauren Cohen, MA, PMP, Duke Clinical Research Institute, Duke University School of Medicine, 300 West Morgan Street, Durham, NC 27701. E-mail: [lauren.w.cohen@duke.edu](lauren.w.cohen@duke.edu).  \nCopyright © 2026 The Author(s) . Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nDOI: 10. 1097/MLR.0000000000002245  \nprovide lessons learned from our accumulated experience that translates the PCORnet infrastructure into a continuously learning framework and highlight unique capabilities of the PCORnet infrastructure supporting innovation in future trials.  \nKey Words: PCORnet, clinical research, clinical trials, real-world data  \n(Med Care 2026;64:S178–S184)  \nP CORnet®, funded by the Patient-Centered Outcomes  \nResearch Institute (PCORI), was designed to enhance the ability to conduct efficient, patient-centered health research, with a focus on comparative clinical effectiveness research. This robust infrastructure supports a broad range of observational studies and prospective interventional trials via its 8 PCORnet® Clinical Research Networks (CRNs), representing everyday health care encounters with over 47 million people across the","cbCaigMsZOXavWWr","https://ap.wps.com/l/cbCaigMsZOXavWWr","pdf",533162,"English","# Abstract\n# Overview: Studies and Infrastructure\n## PCORnet® Studies and their criteria\n## PCORnet infrastructure resources (e.g., Common Data Model)","[{\"question\":\"What is PCORnet® and what is it designed to do?\",\"answer\":\"PCORnet® is a national resource funded by PCORI, designed to enhance the capacity to conduct efficient, patient-centered health research.\"},{\"question\":\"How do PCORnet® Studies differ from other research using the infrastructure?\",\"answer\":\"PCORnet® Studies are a distinguished subset that meets specific criteria and approval requirements, and they emphasize collaboration, transparency, and continuous improvement.\"},{\"question\":\"What kinds of study designs and resources does PCORnet® support?\",\"answer\":\"The infrastructure supports a variety of study designs, including observational studies and prospective interventional trials, using resources such as the PCORnet Common Data Model (CDM) that harmonizes electronic health record data.\"}]","PCORnet® - An Infrastructure Supporting Innovation in Clinical Study Design | PDF",1790756471,18]