[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31494":3,"doc-seo-31494":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31494,2336464648746,"Skyler","https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",8,"Research & Report","PCN-Fe(III)-PTX Nanoparticles for MRI-Guided High-Efficiency Chemo-Photodynamic Therapy in Pancreatic Cancer","Combination chemo-photodynamic therapy for pancreatic cancer depends on effective drug release and sufficient tumor oxygen. The study develops an Fe(III)-complexed porous coordination network (PCN) to encapsulate PTX, forming PCN-Fe(III)-PTX nanoparticles that release drug in response to laser irradiation and pH changes to enhance intratumoral accumulation. A Fe(III)-driven Fenton-like process converts tumor H2O2 to O2, alleviating hypoxia and strengthening PDT. The nanoparticles also function as a T1-MRI contrast agent for monitoring treatment efficacy, supported by cell and animal results.","cbCail3MHyUzbuHd","https://ap.wps.com/l/cbCail3MHyUzbuHd","pdf",3160977,1,9,"English","en","# Abstract\n# Keywords\n# Introduction\n## Rationale and clinical challenge in pancreatic cancer\n## Nanocarriers and light-triggered drug release\n## Chemotherapy–PDT synergy and oxygen limitation\n## Strategies to overcome tumor hypoxia","[{\"question\":\"What is the main therapeutic strategy proposed for pancreatic cancer?\",\"answer\":\"The work uses Fe(III)-complexed porous coordination network nanoparticles to combine chemotherapy with singlet oxygen-dependent photodynamic therapy (PDT). Drug delivery and oxygen modulation are integrated to improve treatment effectiveness under hypoxic tumor conditions.\"},{\"question\":\"How do the PCN-Fe(III)-PTX nanoparticles trigger drug release?\",\"answer\":\"They are designed to release the drug in response to laser irradiation and pH changes, promoting drug accumulation within tumors.\"},{\"question\":\"How do the nanoparticles address tumor hypoxia to enhance PDT?\",\"answer\":\"Through an Fe(III)-based Fenton-like reaction, the nanoparticles convert H2O2 at the tumor site into O2. This regulates local hypoxic conditions, improving the efficacy of PDT.\"}]",1779570152,23,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"pcn-feiii-ptx-nanoparticles-for-mri-guided-high-efficiency-chemo-photodynamic-therapy-in-pancreatic-cancer","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/pcn-feiii-ptx-nanoparticles-for-mri-guided-high-efficiency-chemo-photodynamic-therapy-in-pancreatic-cancer/31494/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-23",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What is the main therapeutic strategy proposed for pancreatic cancer?","Question",{"text":73,"@type":74},"The work uses Fe(III)-complexed porous coordination network nanoparticles to combine chemotherapy with singlet oxygen-dependent photodynamic therapy (PDT). Drug delivery and oxygen modulation are integrated to improve treatment effectiveness under hypoxic tumor conditions.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How do the PCN-Fe(III)-PTX nanoparticles trigger drug release?",{"text":78,"@type":74},"They are designed to release the drug in response to laser irradiation and pH changes, promoting drug accumulation within tumors.",{"name":80,"@type":71,"acceptedAnswer":81},"How do the nanoparticles address tumor hypoxia to enhance PDT?",{"text":82,"@type":74},"Through an Fe(III)-based Fenton-like reaction, the nanoparticles convert H2O2 at the tumor site into O2. This regulates local hypoxic conditions, improving the efficacy of PDT.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]