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Patients diagnosed with periodontitis were identified from Taiwan’s National Health Insurance Research Database and matched 1:1 with patients without periodontitis between 2001 and 2010. A multivariable Cox survival model estimated stroke risk while adjusting for confounding factors. Overall cumulative stroke incidence was higher in periodontitis patients, with additional stroke-related risks observed for several comorbidities.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/patients-with-periodontitis-are-at-a-higher-risk-of-stroke-a-taiwanese-cohort-study/436437/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/patients-with-periodontitis-are-at-a-higher-risk-of-stroke-a-taiwanese-cohort-study/436437.png","ImageObject",300,407,{"name":92,"@type":93},"Jacob","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was the cohort constructed for evaluating stroke risk?","Question",{"text":112,"@type":113},"Patients with periodontitis were selected from Taiwan’s National Health Insurance Research Database and matched 1:1 with patients without periodontitis from 2001 to 2010. A minimum 5-year follow-up was ensured.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What statistical approach was used to assess stroke risk?",{"text":117,"@type":113},"A multivariable Cox survival model was used to predict stroke incidence between periodontitis and nonperiodontitis groups while considering potential confounders. Hazard ratios with 95% confidence intervals were reported.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding stroke incidence?",{"text":121,"@type":113},"The overall cumulative incidence of stroke was 2.14 times higher in patients with periodontitis than in those without. Adjusted hazard ratios indicated a significantly increased stroke risk in the periodontitis group.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436437,1790740250,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962084931830,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","J Chin MedAssoc  \nOriginal article  \nPatients with periodontitis are at a higher risk of stroke: A Taiwanese cohort study  \nPei-Wei Hsua, Yen-Wen Shena,b, Syamsiah Syama,c, Wen-Miin Liangd, Trong-Neng Wue, Jui-Ting Hsua,f,* , Lih-Jyh Fuha,b,*  \naSchool of Dentistry, China Medical University, Taichung, Taiwan, ROC; bDepartment of Dentistry, China Medical University and Hospital, Taichung, Taiwan, ROC; cFaculty of Dentistry, Universitas Muslim Indonesia, Makassar, Indonesia; dDepartment of Health Services Administration, China Medical University, Taichung, Taiwan, ROC; eDepartment of Healthcare Administration, Asia University, Taichung, Taiwan, ROC; fDepartment of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, ROC  \nAbstract  \nBackground: This study aimed to investigate the risk of stroke incidence in patients with periodontitis.  \nMethods: Data on patients diagnosed with periodontitis were collected from Taiwan’s National Health Insurance Research Database and were matched (1:1) with patients without periodontitis between 2001 and 2010. A multivariable Cox survival model was used to predict stroke between patients with and without periodontitis, and the possibility of confounders. Hazard ratios (HRs) with 95% confidence intervals (CIs) were used to explore the risk of stroke in the case and control groups. Diseases found during the follow-up period were analyzed to determine possible effects on the study. A total of 282 560 periodontitis and nonperiodontitis patients were enrolled, with most subjects aged 40 to 59 years.  \nResults: The overall cumulative incidence of stroke was 2.14 times higher in periodontitis than in nonperiodontitis, and the highest HR was in the more than 80 years age group (HR = 9.30; 95% CI, 7.06-12.26) . The multivariate Cox model indicated that the adjusted HR (aHR) between the case and control was 2.03 (95% CI, 1.99-2.08), and a higher aHR was associated with hypertension. Atherosclerosis, atrial fibrillation, obesity, kidney disease, anxiety, and gout discovered during follow-up also showed a potential risk of stroke in patients with periodontitis.  \nConclusion: Therefore, this study suggests a high risk of stroke in patients with periodontitis.  \nKeywords: Periodontitis; Stroke; Systemic disease  \n1. INTRODUCTION  \nPeriodontitis is a disease that is currently receiving urgent attention in public health because its prevalence reaches 50% worldwide and it can affect almost all age groups, including adolescents, adults, and the elderly.1–3 The prevalence of periodontal disease is predicted to be increasing annually because of the aging population growth, with periodontitis being more likely to occur in the elderly group.3 The high prevalence of periodontitis will increase the global burden, which has increased more than 50% from 11 years ago.3–5  \nPeriodontal disease is not only evident in periodontitis itself, it increases the risk for the emergence of other systemic diseases; from 1980 to present, 57 systemic diseases have been reported  \n*Address correspondence. Prof. Lih-Jyh Fuh and Prof. Jui-Ting Hsu, School of Dentistry, China Medical University, 91, Hsueh-Shih Road, Taichung 404, Taiwan,  \nROC. E-mail address: [ljfuh@mail.cmu.edu.tw](ljfuh@mail.cmu.edu.tw) (L.-J. Huh); [jthsu@mail.cmu.edu.tw](jthsu@mail.cmu.edu.tw);  \n[richard@ms32.url.com.tw](richard@ms32.url.com.tw) (J.-T. Hsu).  \nAuthor contributions: Dr Pei-Wei Hsu and Dr Yen-Wen Shen contributed equally to this work.  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2022) 85: 1006-1010.  \nReceived December 16, 2021; accepted February 18, 2022.  \ndoi: 10. 1097/JCMA.0000000000000797.  \nCopyright © 2022, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons","cbCaivnspWC9c2xC","https://ap.wps.com/l/cbCaivnspWC9c2xC","pdf",495108,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods\n## Subject selection","[{\"question\":\"How was the cohort constructed for evaluating stroke risk?\",\"answer\":\"Patients with periodontitis were selected from Taiwan’s National Health Insurance Research Database and matched 1:1 with patients without periodontitis from 2001 to 2010. A minimum 5-year follow-up was ensured.\"},{\"question\":\"What statistical approach was used to assess stroke risk?\",\"answer\":\"A multivariable Cox survival model was used to predict stroke incidence between periodontitis and nonperiodontitis groups while considering potential confounders. Hazard ratios with 95% confidence intervals were reported.\"},{\"question\":\"What were the main findings regarding stroke incidence?\",\"answer\":\"The overall cumulative incidence of stroke was 2.14 times higher in patients with periodontitis than in those without. Adjusted hazard ratios indicated a significantly increased stroke risk in the periodontitis group.\"}]","Patients with periodontitis are at a higher risk of stroke - A Taiwanese cohort study | PDF",1790677934,13]