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A planned secondary analysis measured real-time PROs and monthly QOL using a customized mobile app and FACT-G. Among surgical patients, QOL/PRO associations with Clavien-Dindo grade ≥2 complications were evaluated with univariate analyses.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/patient-reported-outcomes-during-neoadjuvant-therapy-for-gastrointestinal-cancer-and-their-association-with-postoperative-complications/376195/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/patient-reported-outcomes-during-neoadjuvant-therapy-for-gastrointestinal-cancer-and-their-association-with-postoperative-complications/376195.png","ImageObject",300,407,{"name":92,"@type":93},"Dipper","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What question does the study address about neoadjuvant therapy?","Question",{"text":113,"@type":114},"It evaluates whether patient-reported outcomes and quality of life during neoadjuvant therapy can predict postoperative complications after surgery for gastrointestinal and hepatopancreaticobiliary malignancies.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were PROs and QOL measured during neoadjuvant therapy?",{"text":118,"@type":114},"A customized mobile-phone application measured real-time PROs and collected monthly QOL using the FACT-G questionnaire.",{"name":120,"@type":111,"acceptedAnswer":121},"Which PRO signals were more common among patients who developed complications?",{"text":122,"@type":114},"Patients with complications more often reported lack of appetite and pain, and were less likely to report fatigue, anxiety, trouble sleeping, lack of focus, depression, and frustration.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},376195,1790445875,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Journal of Gastrointestinal Cancer (2025) 56:146 [https://doi.org/10.1007/s12029-025-01268-y](https://doi.org/10.1007/s12029-025-01268-y)  \nPatient‑Reported Outcomes During Neoadjuvant Therapy for Gastrointestinal Cancer and Their Association with Postoperative Complications  \nAlexander H. Shannon1 · Samantha M. Ruff1 · Marilly Palettas1 · Angela Sarna1 · Emily Huang1 · Peter J. Kneuertz1 · Mary Dillhoff1 · Aslam Ejaz2 · Timothy M. Pawlik1 · Jordan M. Cloyd1  \nAccepted: 23 June 2025 © The Author(s) 2025  \nAbstract  \nPurpose Neoadjuvant therapy (NT) given before surgery for gastrointestinal (GI) malignancies can lead to adverse events. Whether patient-reported outcomes (PRO) or quality of life (QOL) during NT is predictive of postoperative complications is unknown.  \nMethods A planned secondary analysis of patients with GI cancers undergoing NT utilized a customized mobile-phone application (app) to measure real-time PROs and monthly QOL using FACT-G (Functional Assessment of Cancer TherapyGeneral) . Among surgical patients, the association between QOL and PROs and postoperative Clavien-Dindo grade ≥ 2 complications was analyzed using univariate analyses.  \nResults Among 104 patients enrolled, 69 (66%) underwent surgery following NT and 20 (28.9%) experienced 30-day complications. There were no differences in baseline demographics, NT duration, or cancer type between Complications and No Complications groups (all p>0.05). QOL scores at NT start (mean FACT-G Complications 76.1 vs No Complications 75.2), and changes in QOL during NT did not differ between the two cohorts (p>0.05) . PRO entries of those who experienced complications were more likely to report lack of appetite (25.9% vs 14.2%; p\u003C 0.001) and pain (36.6% vs 18.7%; p\u003C 0.001) but less likely to report fatigue (31.9% vs 41.6%; p = 0.009), anxiety (18.1% vs 39.1%; p\u003C 0.001), trouble sleeping (20.8% vs 39.1%; p\u003C 0.001), lack of focus (5.6% vs 18.5%; p \u003C 0.001), depression (0.5% vs 14%; p \u003C 0.001), and frustration (13.9% vs 21.4%; p = 0.01) . Conclusion In this prospective cohort study, specific PROs were associated with postoperative complications among those who underwent surgical resection. Further research is needed to assess whether preoperative PROs can guide patient-centered interventions mitigating postoperative complications.  \nKeywords Patient-reported outcome measures · Preoperative therapy Pancreatic cancer · Colorectal cancer · Hepatopancreatobiliary surgery · Esophageal cancer  \nIntroduction  \nThe delivery of non-surgical cancer treatments such as chemotherapy or radiotherapy prior to surgical resection, known as neoadjuvant therapy (NT), has increased in recent  \n* Jordan M. Cloyd [Jordan.cloyd@osumc.edu](Jordan.cloyd@osumc.edu)  \n1 Division of Surgical Oncology, The Ohio State University Wexner Medical Center, 410 W 10Th Ave, N-907 Doan Hall, Columbus, OH 43210, USA  \n2 University of Illinois-Chicago Health System, Chicago, IL, USA  \nyears, and it represents the standard of care for many specific gastrointestinal (GI) cancers such as rectal, esophageal, and gastric [1–4] . Benefits of NT include downstaging locally advanced cancers, improving locoregional control, organ preservation, and allowing for minimally invasive surgical techniques [5–7] . Additionally, NT provides valuable information regarding tumor biology and the effectiveness of therapies. Finally, NT improves receipt of multimodality therapy prior to surgical resection, which can be morbid and delay subsequent adjuvant therapy [8, 9] .  \nHowever, as NT becomes increasingly standardized in the management of GI malignancies, its impact on postoperative complications needs to be expounded. NT can cause significant symptoms in patients, has a high incidence of  \nadverse events, and impacts both emotional and physical well-being [10, 11] . In some cases, aggressive preoperative therapy can even lead to sufficient performance status decline to render patients no longer eligible for surgery [12] . In ","cbCaiutnvBkE5CM5","https://ap.wps.com/l/cbCaiutnvBkE5CM5","pdf",906862,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods\n## Patient Population\n## Clinical Outcomes","[{\"question\":\"What question does the study address about neoadjuvant therapy?\",\"answer\":\"It evaluates whether patient-reported outcomes and quality of life during neoadjuvant therapy can predict postoperative complications after surgery for gastrointestinal and hepatopancreaticobiliary malignancies.\"},{\"question\":\"How were PROs and QOL measured during neoadjuvant therapy?\",\"answer\":\"A customized mobile-phone application measured real-time PROs and collected monthly QOL using the FACT-G questionnaire.\"},{\"question\":\"Which PRO signals were more common among patients who developed complications?\",\"answer\":\"Patients with complications more often reported lack of appetite and pain, and were less likely to report fatigue, anxiety, trouble sleeping, lack of focus, depression, and frustration.\"}]","Patient-Reported Outcomes During Neoadjuvant Therapy for Gastrointestinal Cancer and Their Association with Postoperative Complications | PDF",1790217680]