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T􀀇􀀉􀀓 􀀉􀀓 􀀌􀀍 􀀏p􀀂􀀍 -􀀌􀀆􀀆􀀂􀀓􀀓 􀀌􀀐􀀃􀀉􀀆􀀘􀀂 􀀊􀀉􀀓􀀃􀀐􀀉bu􀀃􀀂􀀊 u􀀍􀀊􀀂􀀐 􀀃􀀇􀀂 􀀃􀀂􀀐􀀈􀀓 􀀏􀀎􀀃􀀇􀀂 C􀀐􀀂􀀌􀀃􀀉􀀒􀀂 C􀀏􀀈􀀈􀀏􀀍􀀓 􀀗􀀃􀀃􀀐􀀉bu􀀃􀀉􀀏􀀍 L􀀉􀀆􀀂􀀍􀀓􀀂(CC 􀀚Y) . T􀀇􀀂 u􀀓􀀂􀀋 􀀊􀀉􀀓􀀃􀀐􀀉bu􀀃􀀉􀀏􀀍 􀀏􀀐 􀀐􀀂p􀀐􀀏􀀊u􀀆􀀃􀀉􀀏􀀍􀀉􀀍 􀀏􀀃􀀇􀀂􀀐 􀀎􀀏􀀐u􀀈􀀓 􀀉􀀓 p􀀂􀀐􀀈􀀉􀀃􀀃􀀂􀀊􀀋 p􀀐􀀏􀀒􀀉􀀊􀀂􀀊 􀀃􀀇􀀂􀀏􀀐􀀉􀀝􀀉􀀍􀀌􀀘 􀀌u􀀃􀀇􀀏􀀐(􀀓) 􀀌􀀍􀀊 􀀃􀀇􀀂 􀀆􀀏p􀀔􀀐􀀉􀀝􀀇􀀃 􀀏w􀀍􀀂􀀐(􀀓)􀀌􀀐􀀂 􀀆􀀐􀀂􀀊􀀉􀀃􀀂􀀊 􀀌􀀍􀀊 􀀃􀀇􀀌􀀃 􀀃􀀇􀀂 􀀏􀀐􀀉􀀝􀀉􀀍􀀌􀀘 pub􀀘􀀉􀀆􀀌􀀃􀀉􀀏􀀍􀀉􀀍 􀀃􀀇􀀉􀀓 􀀙􀀏u􀀐􀀍􀀌􀀘 􀀉􀀓 􀀆􀀉􀀃􀀂􀀊􀀋 􀀉􀀍 􀀌􀀆􀀆􀀏􀀐􀀊􀀌􀀍􀀆􀀂 w􀀉􀀃􀀇􀀌􀀆􀀆􀀂p􀀃􀀂􀀊 􀀌􀀆􀀌􀀊􀀂􀀈􀀉􀀆 p􀀐􀀌􀀆􀀃􀀉􀀆􀀂 . N􀀏 u􀀓􀀂􀀋􀀊􀀉􀀓􀀃􀀐􀀉bu􀀃􀀉􀀏􀀍 􀀏􀀐 􀀐􀀂p􀀐􀀏􀀊u􀀆􀀃􀀉􀀏􀀍 􀀉􀀓 p􀀂􀀐􀀈􀀉􀀃􀀃􀀂􀀊 w􀀇􀀉􀀆􀀇 􀀊􀀏􀀂􀀓 􀀍􀀏􀀃 􀀆􀀏􀀈p􀀘􀀔 w􀀉􀀃􀀇 􀀃􀀇􀀂􀀓􀀂 􀀃􀀂􀀐􀀈􀀓 .  \n􀀁􀀂􀀃􀀄􀀅􀀆􀀃􀀇􀀈􀀉􀀆􀀃􀀊􀀉􀀋􀀋􀀅􀀌 􀀎􀀏􀀐􀀈􀀏􀀃􀀂􀀆􀀅􀀉􀀏􀀎􀀂􀀆􀀂􀀋􀀑􀀅􀀎􀀄􀀂 􀀒􀀄􀀃􀀓 􀀓􀀔􀀌􀀊􀀉􀀕􀀉􀀊􀀖􀀓􀀉􀀆􀀅􀀄􀀆 􀀈􀀂􀀆􀀈􀀅􀀊 􀀖􀀂􀀄􀀆 􀀕􀀂􀀆􀀂􀀑􀀅􀀕􀀅􀀆􀀃  \n􀀗􀀓􀀉􀀆􀀑􀀘􀀂􀀄 􀀙􀀂􀀆􀀑 􀀚 􀀂􀀆􀀌 􀀁􀀅􀀆􀀑􀀛􀀄􀀆􀀑 􀀜􀀄􀀂􀀉􀀝􀀞  \n1 D􀀂p􀀌􀀐􀀃􀀈􀀂􀀍􀀃 􀀏􀀎 􀀁􀀌􀀉􀀍 􀀕􀀂􀀊􀀉􀀆􀀉􀀍􀀂 􀀌􀀍􀀊 R􀀂􀀇􀀌b􀀉􀀘􀀉􀀃􀀌􀀃􀀉􀀏􀀍􀀋 T􀀇􀀂 F􀀏u􀀐􀀃􀀇 H􀀏􀀓p􀀉􀀃􀀌􀀘 􀀏􀀎 H􀀂b􀀂􀀉 􀀕􀀂􀀊􀀉􀀆􀀌􀀘 􀀑􀀍􀀉􀀒􀀂􀀐􀀓􀀉􀀃􀀔􀀋􀀅􀀇􀀉􀀙􀀉􀀌􀀖􀀇u􀀌􀀍􀀝􀀋 H􀀂b􀀂􀀉􀀋 C􀀇􀀉􀀍􀀌􀀋 2D􀀂p􀀌􀀐􀀃􀀈􀀂􀀍􀀃 􀀏􀀎 R􀀇􀀂u􀀈􀀌􀀃􀀏􀀘􀀏􀀝􀀔 􀀌􀀍􀀊 􀀛􀀈􀀈u􀀍􀀏􀀘􀀏􀀝􀀔􀀋 T􀀇􀀂 F􀀏u􀀐􀀃􀀇 H􀀏􀀓p􀀉􀀃􀀌􀀘 􀀏􀀎 H􀀂b􀀂􀀉 􀀕􀀂􀀊􀀉􀀆􀀌􀀘 􀀑􀀍􀀉􀀒􀀂􀀐􀀓􀀉􀀃􀀔􀀋 􀀅􀀇􀀉􀀙􀀉􀀌􀀖􀀇u􀀌􀀍􀀝􀀋 H􀀂b􀀂􀀉􀀋 C􀀇􀀉􀀍􀀌  \n􀀆􀀕􀀖􀀗􀀘􀀙􀀚􀀛􀀜􀀝􀀞 C􀀌􀀍􀀆􀀂􀀐 p􀀌􀀉􀀍 􀀉􀀓 􀀌 􀀓􀀉􀀝􀀍􀀉fi􀀆􀀌􀀍􀀃 pub􀀘􀀉􀀆 􀀇􀀂􀀌􀀘􀀃􀀇 􀀆􀀏􀀍􀀆􀀂􀀐􀀍 w􀀏􀀐􀀘􀀊w􀀉􀀊􀀂􀀋􀀍􀀂􀀆􀀂􀀓􀀓􀀉􀀃􀀌􀀃􀀉􀀍􀀝 􀀂􀀎􀀎􀀂􀀆􀀃􀀉􀀒􀀂 􀀈􀀌􀀍􀀌􀀝􀀂􀀈􀀂􀀍􀀃 􀀓􀀃􀀐􀀌􀀃􀀂􀀝􀀉􀀂􀀓 . T􀀇􀀉􀀓 􀀓􀀃u􀀊􀀔 􀀌􀀉􀀈􀀂􀀊 􀀃􀀏 􀀂xp􀀘􀀏􀀐􀀂􀀃􀀇􀀂 􀀂􀀎􀀎􀀂􀀆􀀃􀀓 􀀏􀀎 p􀀌􀀃􀀉􀀂􀀍􀀃-􀀆􀀏􀀍􀀃􀀐􀀏􀀘􀀘􀀂􀀊 􀀓ub􀀆u􀀃􀀌􀀍􀀂􀀏u􀀓 􀀌􀀍􀀌􀀘􀀝􀀂􀀓􀀉􀀌 (􀀁C􀀅􀀗) w􀀉􀀃􀀇􀀇􀀔􀀊􀀐􀀏􀀈􀀏􀀐p􀀇􀀏􀀍􀀂 􀀇􀀔􀀊􀀐􀀏􀀆􀀇􀀘􀀏􀀐􀀉􀀊􀀂 􀀉􀀍􀀙􀀂􀀆􀀃􀀉􀀏􀀍 􀀏􀀍 􀀐􀀂􀀎􀀐􀀌􀀆􀀃􀀏􀀐􀀔 􀀆􀀌􀀍􀀆􀀂􀀐 p􀀌􀀉􀀍 .  \neth􀀚􀀝s􀀞 W􀀂 􀀆􀀏􀀍􀀊u􀀆􀀃􀀂􀀊 􀀌 􀀐􀀂􀀃􀀐􀀏􀀓p􀀂􀀆􀀃􀀉􀀒􀀂 􀀏b􀀓􀀂􀀐􀀒􀀌􀀃􀀉􀀏􀀍􀀌􀀘 􀀓􀀃u􀀊􀀔 􀀉􀀍􀀒􀀏􀀘􀀒􀀉􀀍􀀝 p􀀌􀀃􀀉􀀂􀀍􀀃􀀓 w􀀇􀀏 􀀐􀀂􀀆􀀂􀀉􀀒􀀂􀀊 􀀁C􀀅􀀗 w􀀉􀀃􀀇 􀀇􀀔􀀊􀀐􀀏􀀈􀀏􀀐p􀀇􀀏􀀍􀀂 􀀇􀀔􀀊􀀐􀀏􀀆􀀇􀀘􀀏􀀐􀀉􀀊􀀂 􀀉􀀍􀀙􀀂􀀆􀀃􀀉􀀏􀀍 􀀌􀀃 􀀏u􀀐􀀇􀀏􀀓p􀀉􀀃􀀌􀀘 􀀎􀀐􀀏􀀈 D􀀂􀀆􀀂􀀈b􀀂􀀐 2022 􀀃􀀏 􀀕􀀌􀀔 2023 . 􀀗􀀘􀀘 p􀀌􀀃􀀉􀀂􀀍􀀃􀀓 􀀉􀀍 􀀃􀀇􀀉􀀓 􀀓􀀃u􀀊􀀔 w􀀂􀀐􀀂􀀉􀀍􀀉􀀃􀀉􀀌􀀘􀀘􀀔 􀀇􀀏􀀓p􀀉􀀃􀀌􀀘􀀉􀀖􀀂􀀊 􀀃􀀏 u􀀍􀀊􀀂􀀐􀀝􀀏 􀀊􀀏􀀓􀀂 􀀃􀀉􀀃􀀐􀀌􀀃􀀉􀀏􀀍 􀀌􀀍􀀊 􀀓􀀌􀀎􀀂􀀃􀀔 􀀌􀀓􀀓􀀂􀀓􀀓􀀈􀀂􀀍􀀃 􀀎􀀏􀀐􀀓ub􀀆u􀀃􀀌􀀍􀀂􀀏u􀀓 􀀇􀀔􀀊􀀐􀀏􀀈􀀏􀀐p􀀇􀀏􀀍􀀂 􀀁C􀀅􀀗􀀋 􀀂􀀍􀀓u􀀐􀀉􀀍􀀝 􀀊􀀐u􀀝 􀀃􀀏􀀘􀀂􀀐􀀌􀀍􀀆􀀂 􀀌􀀍􀀊 􀀓􀀃􀀌b􀀘􀀂 pu􀀈p 􀀏p􀀂􀀐􀀌􀀃􀀉􀀏􀀍 . 􀀗􀀎􀀃􀀂􀀐 􀀌􀀆􀀇􀀉􀀂􀀒􀀉􀀍􀀝 􀀊􀀏􀀓􀀂 􀀓􀀃􀀌b􀀉􀀘􀀉􀀖􀀌􀀃􀀉􀀏􀀍􀀋 􀀈􀀏􀀓􀀃 p􀀌􀀃􀀉􀀂􀀍􀀃􀀓 􀀆􀀏􀀍􀀃􀀉􀀍u􀀂􀀊􀀌􀀍􀀌􀀘􀀝􀀂􀀓􀀉􀀆 􀀃􀀇􀀂􀀐􀀌p􀀔 􀀌􀀃 􀀇􀀏􀀈􀀂 u􀀓􀀉􀀍􀀝 􀀃􀀇􀀂 pu􀀈p􀀋 w􀀉􀀃􀀇 􀀊􀀔􀀍􀀌􀀈􀀉􀀆 􀀈􀀏􀀍􀀉􀀃􀀏􀀐􀀉􀀍􀀝 􀀌􀀍􀀊􀀊􀀏􀀓􀀂 􀀌􀀊􀀙u􀀓􀀃􀀈􀀂􀀍􀀃􀀓 􀀆􀀏􀀍􀀊u􀀆􀀃􀀂􀀊 􀀒􀀉􀀌 􀀃􀀂􀀘􀀂p􀀇􀀏􀀍􀀂 􀀎􀀏􀀘􀀘􀀏w-up􀀓 􀀌􀀍􀀊 􀀏u􀀃p􀀌􀀃􀀉􀀂􀀍􀀃 􀀒􀀉􀀓􀀉􀀃􀀓 .􀀁􀀌􀀉􀀍 w􀀌􀀓 􀀌􀀓􀀓􀀂􀀓􀀓􀀂􀀊 u􀀓􀀉􀀍􀀝 􀀃􀀇􀀂 􀀍u􀀈􀀂􀀐􀀉􀀆􀀌􀀘 􀀐􀀌􀀃􀀉􀀍􀀝 􀀓􀀆􀀌􀀘􀀂 (NR􀀅)􀀋 w􀀇􀀉􀀘􀀂 􀀌􀀍x􀀉􀀂􀀃􀀔 􀀌􀀍􀀊􀀊􀀂p􀀐􀀂􀀓􀀓􀀉􀀏􀀍 w􀀂􀀐􀀂 􀀂􀀒􀀌􀀘u􀀌􀀃􀀂􀀊 u􀀓􀀉􀀍􀀝 􀀃􀀇􀀂 E􀀊􀀈􀀏􀀍􀀃􀀏􀀍 􀀅􀀔􀀈p􀀃􀀏􀀈 􀀗􀀓􀀓􀀂􀀓􀀓􀀈􀀂􀀍􀀃 􀀅􀀆􀀌􀀘􀀂(E􀀅􀀗􀀅-R) 􀀌􀀍􀀊 􀀓􀀘􀀂􀀂p 􀀞u􀀌􀀘􀀉􀀃􀀔 w􀀌􀀓 􀀈􀀂􀀌􀀓u􀀐􀀂􀀊 w􀀉􀀃􀀇 􀀃􀀇􀀂 􀀁􀀉􀀃􀀃􀀓bu􀀐􀀝􀀇 􀀅􀀘􀀂􀀂p Qu􀀌􀀘􀀉􀀃􀀔􀀛􀀍􀀊􀀂x (􀀁􀀅Q􀀛) . T􀀇􀀂 􀀉􀀍􀀆􀀉􀀊􀀂􀀍􀀆􀀂 􀀏􀀎 􀀌􀀊􀀒􀀂􀀐􀀓􀀂 􀀊􀀐u􀀝 􀀐􀀂􀀌􀀆􀀃􀀉􀀏􀀍􀀓 w􀀌􀀓 􀀌􀀘􀀓􀀏 􀀊􀀏􀀆u􀀈􀀂􀀍􀀃􀀂􀀊 .  \n􀀈es􀀛lts􀀞 T􀀇􀀂 􀀃􀀐􀀂􀀌􀀃􀀈􀀂􀀍􀀃 􀀊􀀂􀀈􀀏􀀍􀀓􀀃􀀐􀀌􀀃􀀂􀀊 􀀓􀀉􀀝􀀍􀀉fi􀀆􀀌􀀍􀀃 􀀉􀀈p􀀐􀀏􀀒􀀂􀀈􀀂􀀍􀀃 􀀌􀀆􀀐􀀏􀀓􀀓 􀀌􀀘􀀘􀀏b􀀓􀀂􀀐􀀒􀀂􀀊 p􀀌􀀐􀀌􀀈􀀂􀀃􀀂􀀐􀀓 . 􀀗􀀎􀀃􀀂􀀐 􀀃􀀇􀀂 􀀆􀀏􀀍􀀃􀀉􀀍u􀀏u􀀓 􀀓ub􀀆u􀀃􀀌􀀍􀀂􀀏u􀀓 􀀉􀀍􀀙􀀂􀀆􀀃􀀉􀀏􀀍 􀀏􀀎􀀇􀀔􀀊􀀐􀀏􀀈􀀏􀀐p􀀇􀀏􀀍􀀂 􀀇􀀔􀀊􀀐􀀏􀀆􀀇􀀘􀀏􀀐􀀉􀀊􀀂 􀀉􀀍􀀎u􀀓􀀉􀀏􀀍 􀀎􀀏􀀐 􀀌􀀍􀀌􀀘􀀝􀀂􀀓􀀉􀀌􀀋􀀃􀀇􀀂 􀀈􀀂􀀊􀀉􀀌􀀍 NR􀀅 p􀀌􀀉􀀍􀀓􀀆􀀏􀀐􀀂 􀀊􀀂􀀆􀀐􀀂􀀌􀀓􀀂􀀊 􀀎􀀐􀀏􀀈 6 􀀃􀀏 1 ( 􀀁 \u003C 0 . 0001)􀀋 􀀃􀀇􀀂 􀀈􀀂􀀌􀀍 􀀓􀀘􀀂􀀂p 􀀞u􀀌􀀘􀀉􀀃􀀔 􀀓􀀆􀀏􀀐􀀂􀀊􀀂􀀆􀀐􀀂􀀌􀀓􀀂􀀊 􀀎􀀐􀀏􀀈 13 . 85 􀀃􀀏 7 .488 ( 􀀁 \u003C 0 . 0001)􀀋 􀀃􀀇􀀂 􀀈􀀂􀀊􀀉􀀌􀀍 􀀌􀀍x􀀉􀀂􀀃􀀔 􀀓􀀃􀀌􀀃􀀂 􀀓􀀆􀀏􀀐􀀂􀀊􀀂􀀆􀀐􀀂􀀌􀀓􀀂􀀊 􀀎􀀐􀀏􀀈 5 􀀃􀀏 1 ( 􀀁 \u003C 0 . 0001)􀀋 􀀃􀀇􀀂 􀀈􀀂􀀊􀀉􀀌􀀍 􀀊􀀂p􀀐􀀂􀀓􀀓􀀉􀀏􀀍 􀀓􀀆􀀏􀀐􀀂 􀀊􀀂􀀆􀀐􀀂􀀌􀀓􀀂􀀊􀀎􀀐􀀏􀀈 􀀌 b􀀌􀀓􀀂􀀘􀀉􀀍􀀂 􀀏􀀎 3 􀀃􀀏 0 . 5 ( 􀀁 \u003C 0 . 0001)􀀋 􀀌􀀍􀀊 􀀃􀀇􀀂 􀀈􀀂􀀊􀀉􀀌􀀍 􀀂􀀞u􀀉􀀒􀀌􀀘􀀂􀀍􀀃 􀀏􀀐􀀌􀀘􀀈􀀏􀀐p􀀇􀀉􀀍􀀂 􀀊􀀏􀀓􀀂 􀀊􀀂􀀆􀀐􀀂􀀌􀀓􀀂􀀊 􀀎􀀐􀀏􀀈 140 􀀈􀀝 􀀃􀀏 52 􀀈􀀝 ( 􀀁 \u003C 0 . 0001) .  \n􀀋􀀚􀀜􀀖l􀀛si􀀚􀀜s􀀞 􀀁C􀀅􀀗 w􀀉􀀃􀀇 􀀇􀀔􀀊􀀐􀀏􀀈􀀏􀀐p􀀇􀀏􀀍􀀂 􀀇􀀔􀀊􀀐􀀏􀀆􀀇􀀘􀀏􀀐􀀉􀀊􀀂 􀀉􀀍􀀙􀀂􀀆􀀃􀀉􀀏􀀍 􀀏􀀎􀀎􀀂􀀐􀀓􀀓􀀉􀀝􀀍􀀉fi􀀆􀀌􀀍􀀃 􀀃􀀇􀀂􀀐􀀌p􀀂u􀀃􀀉􀀆 b􀀂􀀍􀀂fi􀀃􀀓 􀀎􀀏􀀐 􀀐􀀂􀀎􀀐􀀌􀀆􀀃􀀏􀀐􀀔 􀀆􀀌􀀍􀀆􀀂􀀐 p􀀌􀀉􀀍 . 􀀛􀀃 􀀂􀀎􀀎􀀂􀀆􀀃􀀉􀀒􀀂􀀘􀀔􀀐􀀂􀀊u􀀆􀀂􀀓 p􀀌􀀉􀀍 􀀉􀀍􀀃􀀂􀀍􀀓􀀉􀀃􀀔􀀋 􀀊􀀂􀀆􀀐􀀂􀀌􀀓􀀂􀀓 􀀏p􀀉􀀏􀀉􀀊 􀀊􀀏􀀓􀀌􀀝􀀂􀀋 􀀈􀀉􀀃􀀉􀀝􀀌􀀃􀀂􀀓 􀀆􀀂􀀐􀀃􀀌􀀉􀀍 􀀌􀀊􀀒􀀂􀀐􀀓􀀂􀀐􀀂􀀌􀀆􀀃􀀉􀀏􀀍􀀓􀀋 􀀌􀀍􀀊 􀀉􀀓 􀀌􀀓􀀓􀀏􀀆􀀉􀀌􀀃􀀂􀀊 w􀀉􀀃􀀇 􀀐􀀂􀀊u􀀆􀀂􀀊 􀀌􀀍x􀀉􀀂􀀃􀀔 􀀌􀀍􀀊 􀀊􀀂p􀀐􀀂􀀓􀀓􀀉􀀏􀀍 􀀌􀀓 w􀀂􀀘􀀘 􀀌􀀓􀀉􀀈p􀀐􀀏􀀒􀀂􀀊 􀀓􀀘􀀂􀀂p 􀀞u􀀌􀀘􀀉􀀃􀀔 .  \nK􀀁􀀇􀀊􀀌􀀈􀀂􀀍  \nhy􀀝􀀙􀀚m􀀚􀀙ph􀀚􀀜e, s􀀛b􀀖􀀛t􀀕􀀜e􀀚􀀛s i􀀜je􀀖ti􀀚􀀜, 􀀙ef􀀙􀀕􀀖t􀀚􀀙y 􀀖􀀕􀀜􀀖e􀀙 p􀀕i􀀜, p􀀕i􀀜 s􀀖􀀚􀀙e, 􀀕􀀜xiety,􀀝ep􀀙essi􀀚􀀜  \n􀀆􀀃􀀊􀀉􀀌􀀏􀀈􀀃􀀄􀀉􀀆  \n􀀁􀀂􀀃 􀀅􀀆􀀇􀀈􀀉􀀇􀀊􀀋􀀊 􀀇􀀌 􀀍􀀎􀀉􀀏 􀀐􀀏􀀅􀀃􀀊 􀀇􀀌 􀀑􀀎􀀉􀀑􀀃􀀆 􀀋􀀊 􀀋􀀍􀀅􀀆􀀇􀀒􀀋􀀉􀀈 􀀃􀀎􀀑􀀂 􀀏􀀃􀀎􀀆􀀓 􀀍􀀃􀀎􀀉􀀋􀀉􀀈 􀀐􀀂􀀎􀀐 􀀐􀀂􀀃􀀅􀀆􀀃􀀒􀀎􀀔􀀃􀀉􀀑􀀃 􀀇􀀌 􀀅􀀎􀀐􀀋􀀃􀀉􀀐􀀊 􀀕􀀋􀀐􀀂 􀀑􀀎􀀉􀀑􀀃􀀆 􀀋􀀊 􀀋􀀉􀀑􀀆􀀃􀀎􀀊􀀋􀀉􀀈 􀀖􀀗􀀘􀀙􀀚􀀓 􀀔􀀃􀀎􀀛􀀋􀀉􀀈 􀀐􀀇 􀀎􀀉 􀀋􀀉􀀑􀀆􀀃􀀎􀀊􀀃 􀀋􀀉 􀀐􀀂􀀃􀀌􀀆􀀃􀀜􀀝􀀃􀀉􀀑􀀏 􀀇􀀌 􀀊􀀝􀀆􀀒􀀋􀀒􀀇􀀆􀀊􀀂􀀋􀀅 􀀋􀀊􀀊􀀝􀀃􀀊 􀀖􀀙 􀀓 􀀞􀀚 W􀀋􀀐􀀂 􀀐􀀂􀀃 􀀋􀀉􀀑􀀆􀀃􀀎􀀊􀀋􀀉􀀈 􀀉􀀝􀀍b􀀃􀀆 􀀇􀀌 􀀑􀀎􀀉􀀑􀀃􀀆 􀀑􀀎􀀊􀀃􀀊􀀓􀀑􀀎􀀉􀀑􀀃􀀆 􀀅􀀎􀀋􀀉 􀀂􀀎􀀊 b􀀃􀀑􀀇􀀍􀀃 􀀇􀀉􀀃 􀀇􀀌 􀀐􀀂􀀃 􀀍􀀇􀀊􀀐 􀀋􀀍􀀅􀀇􀀆􀀐􀀎􀀉","cbCaim2aEP9cwZym","https://ap.wps.com/l/cbCaim2aEP9cwZym","pdf",370413,"English","# Study overview\n## Analgesic outcomes and endpoints\n## Safety and adverse effects\n## Results and statistical findings","[{\"question\":\"What intervention is evaluated in the study?\",\"answer\":\"The study evaluates patient-controlled subcutaneous analgesia with hydromorphone for managing cancer pain.\"},{\"question\":\"How are efficacy outcomes assessed?\",\"answer\":\"Efficacy is assessed using analgesic and symptom-related endpoints, with comparisons reported across study conditions and time points.\"},{\"question\":\"What safety information is included?\",\"answer\":\"The document includes safety findings such as adverse events and tolerability-related results for the evaluated regimen.\"}]","Patient-controlled subcutaneous analgesia with hydromorphone in cancer pain management | PDF",1790575675]