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Results used chi-square comparisons between therapy groups to quantify awareness, perceived effectiveness, and intended volunteer participation.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/patient-attitudes-about-light-therapy-and-negative-ion-therapy-for-nonseasonal-depression-an-online-survey-study/411603/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/patient-attitudes-about-light-therapy-and-negative-ion-therapy-for-nonseasonal-depression-an-online-survey-study/411603.png","ImageObject",300,407,{"name":42,"@type":43},"Grenda","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main objective of this online survey study?","Question",{"text":63,"@type":64},"To evaluate feasibility by measuring depression participants’ knowledge and attitudes toward light therapy and negative ion therapy for maintenance after acute antidepressant treatment, and their willingness to join a maintenance trial using these therapies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were participants’ awareness and attitudes assessed?",{"text":68,"@type":64},"Participants with a self-reported depression diagnosis completed a researcher-generated online survey with vignettes describing maintenance use of the therapies. Awareness, effectiveness perceptions, and reasons for wanting or not wanting these therapies were collected and compared using chi-square tests.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find about participant interest and perceived feasibility?",{"text":72,"@type":64},"Most participants were aware of both therapies, with significantly higher awareness, prior use, and perceived effectiveness for light therapy. Both therapies were considered easy to use, and most participants emphasized the importance of non-medication maintenance options and reported likely willingness to volunteer for a randomized study.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},411603,1790674665,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},7971474921005,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Review began 06/18/2025  \nReview ended 11/22/2025  \nPublished 12/01/2025  \n© Copyright 2025  \nHellerstein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98278  \nOpen Access Original Article  \nPatient Attitudes About Light Therapy and Negative Ion Therapy for Nonseasonal Depression: An Online Survey Study  \nOrli S. Hellerstein 1 , Iman Lahouaoula 1, Victor W. Li 2, Aidan Scott 3 , Andre Do 4, Erin E. Michalak 1, Jill K. Murphy 5 , Samantha Huang 1 , Vanessa K. Evans 1, Raymond W. Lam 1  \n1. Psychiatry, University of British Columbia, Vancouver, CAN 2. Psychiatry, University of British Columbia, Faculty of Medicine, Vancouver, CAN 3. Psychiatry, BC Children 's Hospital, Vancouver, CAN 4. Psychiatry, Universite de Montreal, Montreal, CAN 5. Health, St. Francis Xavier University, Antigonish, CAN  \nCorresponding author: Raymond W. Lam, [r.lam@ubc.ca](r.lam@ubc.ca)  \nAbstract  \nObjective: No studies have evaluated the feasibility of light therapy or negative ion therapy as maintenance treatments after acute antidepressant treatment in major depressive disorder. To address this gap, we surveyed people with depression about their knowledge and attitudes about light therapy and negative ion therapy, and their willingness to participate in a clinical trial of maintenance treatment with these therapies.  \nMethods: Participants with a self-reported diagnosis of depression completed a researcher-generated online survey, created for this study, examining awareness and effectiveness of light therapy and negative ion therapy, which included vignettes describing the use of these therapies for maintenance treatment. Participants were asked about the feasibility and reasons for wanting (and not wanting) to use the therapies instead of antidepressants. Response frequencies were compared using chi-square tests.  \nResults: A total of 193 participants completed the survey. Most were aware of both therapies, but significantly more participants had heard of light therapy (95% versus 63% for negative ion therapy, p\u003C0 .001), had used light therapy (29% versus 17%, p\u003C0 .001), and regarded light therapy as effective (54% versus 37%, p\u003C0 .001) . Both therapies were considered easy to use. Most participants (81%) placed importance on finding non-medication therapies for maintenance treatment; 77% responded that they would likely volunteer for a randomized study of maintenance treatment.  \nConclusion: People with depression are aware of light therapy and negative ion therapy and support their usage as substitutes for antidepressants in maintenance treatment. This supports the importance and feasibility of a randomized relapse prevention trial with light therapy and negative ion therapy in people with depression.  \nCategories: Psychiatry, Psychology  \nKeywords: feasibility, ion therapy, light therapy, maintenance treatment, major depressive disorder (mdd), relapse  \nprevention, survey  \nIntroduction  \nMajor depressive disorder (MDD) affects approximately 264 million people worldwide and is one of the top three medical causes of years lived with disability [1] . Amongst the many evidence-based treatment options for MDD, antidepressants are recommended as first-line treatments for moderate to severe depression [2] .  \nOnce patients have recovered from an acute depressive episode, maintenance antidepressant treatment is recommended for 6-24 months, or longer, to prevent relapse and recurrence [2] . Several meta-analyses of  \nrandomized controlled trials (RCTs) have confirmed that maintenance antidepressants are effective in  \npreventing relapse [3-5].  \nDespite the evidence for maintenance, patients often discontinue antidepressants too early after acute  \ntreatment [6] . This puts them at risk of relapse and consequent impairment in ","cbCaicXGhyqKpVq7","https://ap.wps.com/l/cbCaicXGhyqKpVq7","pdf",513576,11,"English","# Abstract\n# Introduction\n## Maintenance antidepressant need\n## Barriers and patient preferences\n## Rationale for non-medication therapies","[{\"question\":\"What was the main objective of this online survey study?\",\"answer\":\"To evaluate feasibility by measuring depression participants’ knowledge and attitudes toward light therapy and negative ion therapy for maintenance after acute antidepressant treatment, and their willingness to join a maintenance trial using these therapies.\"},{\"question\":\"How were participants’ awareness and attitudes assessed?\",\"answer\":\"Participants with a self-reported depression diagnosis completed a researcher-generated online survey with vignettes describing maintenance use of the therapies. Awareness, effectiveness perceptions, and reasons for wanting or not wanting these therapies were collected and compared using chi-square tests.\"},{\"question\":\"What did the study find about participant interest and perceived feasibility?\",\"answer\":\"Most participants were aware of both therapies, with significantly higher awareness, prior use, and perceived effectiveness for light therapy. Both therapies were considered easy to use, and most participants emphasized the importance of non-medication maintenance options and reported likely willingness to volunteer for a randomized study.\"}]","Patient Attitudes About Light Therapy and Negative Ion Therapy for Nonseasonal Depression - An Online Survey Study | PDF",1790589084,28]