[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-406610-105":59,"doc-detail-406610-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pathophysiology-of-depression-and-anxiety-in-metabolic-dysfunction-associated-steatotic-liver-disease","Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease","","Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver condition with rising global burden and meaningful mortality impact. Evidence links MASLD to depression and anxiety through shared cardiometabolic risks, including obesity, type 2 diabetes, and insulin resistance, mediated by systemic inflammation and oxidative stress. Additional proposed contributors include dysregulated hypothalamic-pituitary-adrenal signaling, neurotransmitter imbalance, and gut dysbiosis. The review describes a bidirectional relationship and emphasizes early detection and proactive, holistic diet and lifestyle interventions to reduce combined disease burden.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pathophysiology-of-depression-and-anxiety-in-metabolic-dysfunction-associated-steatotic-liver-disease/406610/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pathophysiology-of-depression-and-anxiety-in-metabolic-dysfunction-associated-steatotic-liver-disease/406610.png","ImageObject",300,407,{"name":92,"@type":93},"Mimi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":56},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition is reviewed, and why is it important globally?","Question",{"text":112,"@type":113},"The review focuses on metabolic dysfunction-associated steatotic liver disease (MASLD), described as the most common chronic liver disease with continually rising global prevalence and significant mortality rates.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How are MASLD and mood disorders such as depression and anxiety connected?",{"text":117,"@type":113},"The paper summarizes shared pathophysiological pathways involving systemic inflammation and oxidative stress, as well as dysregulation of the hypothalamic-pituitary-adrenal axis, neurotransmitter imbalances, and gut dysbiosis. It also notes a bidirectional relationship between the disorders.",{"name":119,"@type":110,"acceptedAnswer":120},"What interventions does the review emphasize for addressing both physical and mental health burden?",{"text":121,"@type":113},"It highlights early detection and a more proactive, holistic approach that includes diet and lifestyle changes. It also points to overlapping risk factors that worsen both disease processes, such as insulin resistance, obesity, poor sleep, and physical inactivity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406610,1790670498,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":56,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},2336477974920,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","| W | J | G | P | World Journal of\u003Cbr>Gastrointestinal Pathophysiology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Pathophysiol 2025 December 22; 16(4): 111029  \nDOI: 10.4291/wjgp.v16.i4.111029 ISSN 2150-5330 (online)  \nREVIEW  \nPathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease  \nSampada, Mohammad Naseem, Mehul Solanki, Ragini Sharma, Carol Singh, Aalam Sohal  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade B, Grade B, Grade C  \nNovelty: Grade B, Grade B, Grade B, Grade B  \nCreativity or Innovation: Grade B, Grade B, Grade B, Grade C Scientific Significance: Grade A, Grade B, Grade B, Grade C  \nP-Reviewer: Chen Y, MD, China; Gutiérrez-Cuevas J, PhD, Full Professor, Mexico; Liu Y, MD, PhD, Postdoctoral Fellow, China  \nReceived: June 23, 2025  \nRevised: July 31, 2025  \nAccepted: November 4, 2025  \nPublished online: December 22, 2025  \nProcessing time: 184 Days and 5.9 Hours  \nSampada, Department of Internal Medicine, Punjab Institute of Medical Sciences, Jalandhar 144009, Punjab, India  \nMohammad Naseem, Mehul Solanki, Department of Internal Medicine, Maulana Azad Medical College, New Delhi 110002, Delhi, India  \nRagini Sharma, Department of Psychiatry, Maulana Azad Medical College, New Delhi 110002, Delhi, India  \nCarol Singh, Department of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India  \nAalam Sohal, Department of Gastroenterology and Hepatology, Creighton University School of Medicine, Phoenix, AZ 85012, United States  \nCorresponding author: Aalam Sohal, MD, Department of Gastroenterology and Hepatology, Creighton University School of Medicine, 3216 NE 45th Pl Suite 212, Phoenix, AZ 85012, [United States.](United States. aalamsohal@gmail.com)[ aalamsohal@gmail.com](United States. aalamsohal@gmail.com)  \nAbstract  \nMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease with a continually rising global prevalence and significant mortality rates. Emerging evidence suggests a strong association between MASLD and mental health disorders such as depression and anxiety. In addition to the shared risk factors such as obesity, type 2 diabetes and insulin resistance which contribute to this relationship through mechanisms involving systemic inflammation and oxidative stress; other pathophysiological mechanisms such as dysregulation of hypothalamic-pituitary-adrenal axis, neurotransmitter imbalances and gut dysbiosis have also been proposed to play a significant role. The current paper aims to review the pathophysiological mechanisms underlying the association between MASLD and mood disorders such as depression and anxiety. We note a bidirectional relationship between these two disorders, and the dual burden of both these disease processes can be alleviated by early detection and encouraging a more proactive and holistic approach through diet and lifestyle changes. This review summarizes the existing literature on association between MASLD and depression.  \nKey Words: Metabolic dysfunction-associated steatotic liver disease; Non-alcoholic fatty  \n WJGP  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 22, 2025  Volume 16  Issue 4   \nSampada et al. MASLD and mood disorders  \nliver disease; Depression; Anxiety; Hypothalamic-pituitary-adrenal axis; Gut-liver-brain axis; Neuroinflammation; Cytokines  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Metabolic dysfunction-associated steatotic liver disease is associated with mood disorders such as depression and anxiety through shared pathophysiological pathways. This review links systemic inflammation, hypothalamic-","cbCaihIO9NlKlM6j","https://ap.wps.com/l/cbCaihIO9NlKlM6j","pdf",1767991,"English","# Abstract\n# Core Tip\n# Introduction and Background\n## MASLD nomenclature and prevalence","[{\"question\":\"What condition is reviewed, and why is it important globally?\",\"answer\":\"The review focuses on metabolic dysfunction-associated steatotic liver disease (MASLD), described as the most common chronic liver disease with continually rising global prevalence and significant mortality rates.\"},{\"question\":\"How are MASLD and mood disorders such as depression and anxiety connected?\",\"answer\":\"The paper summarizes shared pathophysiological pathways involving systemic inflammation and oxidative stress, as well as dysregulation of the hypothalamic-pituitary-adrenal axis, neurotransmitter imbalances, and gut dysbiosis. It also notes a bidirectional relationship between the disorders.\"},{\"question\":\"What interventions does the review emphasize for addressing both physical and mental health burden?\",\"answer\":\"It highlights early detection and a more proactive, holistic approach that includes diet and lifestyle changes. It also points to overlapping risk factors that worsen both disease processes, such as insulin resistance, obesity, poor sleep, and physical inactivity.\"}]","Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease | PDF",1790566729,48]