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Adolescents with Overweight and Obesity, Following the Implementation of a Multidisciplinary Lifestyle Intervention Program  \nAikaterini Vourdoumpa 1, George Paltoglou 2, Maria Manou 1, Diamanto Koutaki 1, Penio Kassari 1,3, Marina Papadopoulou 1, Gerasimos Kolaitis 4 and Evangelia Charmandari 1,3, *  \nAcademic Editor: Yongting Luo  \nReceived: 20 November 2025  \nRevised: 22 December 2025  \nAccepted: 25 December 2025  \nPublished: 1 January 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School,‘Aghia Sophia’ Children’s Hospital, 11527 Athens, Greece; [katvourdouba@gmail.com](katvourdouba@gmail.com) (A.V.); [mariamanou93@hotmail.com](mariamanou93@hotmail.com) (M.M.); [mk_madw@hotmail.com](mk_madw@hotmail.com) (D.K.); [peniokassari@gmail.com](peniokassari@gmail.com) (P.K.); [marinageorpap@gmail.com](marinageorpap@gmail.com) (M.P.)  \n2 Division of Endocrinology, Diabetes and Metabolism, Second Department of Pediatrics, National and Kapodistrian University of Athens,“P. & A. Kyriakou” Children’s Hospital, 11527 Athens, Greece; [gpaltoglou@gmail.com](gpaltoglou@gmail.com)  \n3 Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece  \n4 Department of Child Psychiatry, National and Kapodistrian University of Athens Medical School,‘Aghia Sophia’ Children’s Hospital, 11527 Athens, Greece; [gkolaitis@med.uoa.gr](gkolaitis@med.uoa.gr)  \n* Correspondence: [evangelia.charmandari@googlemail.com](evangelia.charmandari@googlemail.com); Tel.: +30-213-2013384  \nAbstract  \nBackground: Overweight and obesity in childhood and adolescence represent one of the most significant public health challenges of our century. Affected children and adolescents often face psychosocial maladaptation, including low self-esteem, depressive and anxiety symptoms, and behavioral problems, many of which may persist till later in life. The aim of our study was to evaluate the impact of a multidisciplinary, personalized lifestyle intervention program on psychosocial and behavioral symptoms, assessed through standardized psychometric questionnaires, and to investigate their relation with cardiometabolic parameters in children and adolescents with overweight and obesity. Methods: In this prospective cohort study, 537 children and adolescents (6–18 years; females: 52.9%; pubertal: 43.6%) with obesity (n = 44.3%), overweight (n = 33.7%), or normal BMI (n = 22%) participated in a personalized lifestyle intervention program for one year. Clinical and laboratory evaluations, including anthropometric, cardiometabolic, and endocrinologic parameters, as well as psychosocial functioning assessed by the Child Behavior Checklist (CBCL) and Youth Self-Report (YSR), were performed at the beginning and the end of the study. Linear regression analyses identified predictors of psychometric change. Results: At initial evaluation, children and adolescents with obesity displayed a less favorable cardiometabolic profile and greater emotional/conduct difficulties compared to their overweight and normal-BMI counterparts. Following the intervention, significant improvements were observed in BMI, anthropometric and cardiometabolic parameters, as well as reductions in internalizing, externalizing, and total problem scores across multiple CBCL and YSR domains (p \u003C 0.05) . The improvements in psychosocial functioning were partly independent of BMI reduction. Linear regression analyses identified cardiometabolic and endocrine markers as significant predictors of psychometric change (p \u003C 0.05), highlighting interactions betw","cbCaiuSYK8ViZ4rB","https://ap.wps.com/l/cbCaiuSYK8ViZ4rB","pdf",2057916,29,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What is the main aim of the study?\",\"answer\":\"To evaluate the impact of a multidisciplinary, personalized lifestyle intervention program on psychosocial and behavioral symptoms in children and adolescents with overweight and obesity, and to examine relationships with cardiometabolic parameters.\"},{\"question\":\"How were psychosocial and behavioral outcomes assessed?\",\"answer\":\"Psychosocial and behavioral symptoms were assessed using standardized psychometric questionnaires, specifically the Child Behavior Checklist (CBCL) and the Youth Self-Report (YSR), at the beginning and end of the study.\"},{\"question\":\"What changes were observed after the one-year intervention?\",\"answer\":\"Significant improvements occurred in BMI, anthropometric and cardiometabolic parameters, along with reductions in internalizing, externalizing, and total problem scores across CBCL and YSR domains.\"}]","Parallel Improvement of Both Mental and Cardiometabolic Health in Children and Adolescents with Overweight and Obesity, Following the Implementation of a Multidisciplinary Lifestyle Intervention Program | PDF",1790772919,73]