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Using 700 PTC patient samples from Shanxi Provincial People’s Hospital, the study employed a 57-gene thyroid cancer panel to quantify mutation frequencies and evaluate associations between gene variants and clinical information. Younger age and BRAF-related genomic patterns were linked to more advanced tumor and nodal staging.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/papillary-thyroid-carcinoma-correlation-between-molecular-and-clinical-features/333677/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/papillary-thyroid-carcinoma-correlation-between-molecular-and-clinical-features/333677.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How many patients and what gene panel were used to study PTC?","Question",{"text":112,"@type":113},"The study analyzed samples from 700 PTC patients using a thyroid cancer panel covering 57 genes to determine mutation frequencies and correlations with clinical data.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which mutations were most common in the cohort?",{"text":117,"@type":113},"Among the 57 genes examined, BRAF mutations were present in 76.4% of patients, with BRAFV600E representing 90.9% of all BRAF mutations. Other notable driver genes included CHEK2, RET, PIK3CA, and EGFR, and RET fusions were also detected.",{"name":119,"@type":110,"acceptedAnswer":120},"What clinical staging patterns were associated with molecular findings?",{"text":121,"@type":113},"Patients younger than 55 years showed a higher tendency toward advanced N staging, and male patients were more likely to have advanced N stages. Higher BRAF allele frequencies correlated with more advanced T and N stages, and a higher frequency of RET fusions correlated with later T and N stages.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333677,1790625516,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Molecular Diagnosis & Therapy (2024) 28:601–609 [https://doi.org/10.1007/s40291-024-00721-1](https://doi.org/10.1007/s40291-024-00721-1)  \nPapillary Thyroid Carcinoma: Correlation Between Molecular and Clinical Features  \nQiang Wang1 · BoYu2 · Shuilong Zhang1 · Dongliang Wang1 · Zhifu Xiao1 · Hongjing Meng1 · Lingxiang Dong1 · Yuhang Zhang1 · Jie Wu1 · Zebin Hou1 · Yunji Zhu2 · Dewei Li1  \nAccepted: 29 May 2024 / Published online: 19 June 2024 © The Author(s) 2024  \nAbstract  \nBackground Thyroid cancer is prevalent worldwide, including in China, where its incidence is on the rise. Papillary thyroid carcinoma (PTC) is the predominant subtype. Investigating the relationship between clinical data associated with PTC and gene mutations is crucial for improving detection and treatment.  \nPatients and Methods We collected samples and associated clinical data from 700 PTC patients at Shanxi Provincial People’s Hospital. Using a panel of 57 genes linked to thyroid cancer, we sequenced the samples to determine the mutation frequency of thyroid cancer-associated genes in PTC. We further analyzed the correlation between gene variants and clinical information.  \nResults The mean age of patients in this study was 42.5 years. Females predominated, comprising 507 of the total patient population, resulting in a female-to-male ratio of 2.63 (507:193) . Tumor distribution revealed 198, 257, and 142 cases on the left, right, and both sides, respectively. Among the 57 thyroid cancer-related genes analyzed, we identified at least one driver gene in 83 .6% of patients. Notably, 76 .4% had BRAF mutations, mainly BRAFV600E, which constituted 90.9% of all BRAF mutations, with 535 cases exhibiting these mutations. Other significant driver genes included CHEK2 (n = 84), RET (n = 42), PIK3CA (n = 7), and EGFR (n = 7) . RET fusions (n = 28) were also identified. Notably, patients under 55 years old exhibit a higher tendency towards advanced N staging, suggesting that younger individuals may be more prone to lymph node metastasis. Additionally, male patients were more likely to have advanced N stages. Importantly, a positive correlation was observed between higher BRAF allele frequencies and more advanced T and N stages. Similarly, correlation analysis revealed that a greater frequency ofRET fusions correlated with later T and N stages.  \nConclusion This study uncovered several significant insights. Younger PTC patients exhibited a higher propensity for lymph node metastasis. An elevated mutation frequency of BRAF was correlated with a higher occurrence ofRET fusions, predisposing individuals to lymph node metastasis and potentially indicating a poorer prognosis.  \nQiang Wang and Bo Yu contributed equally to this work.  \n* Dewei Li[sxsyldw@163.com](sxsyldw@163.com)  \n1 Department of Thyroid Surgery, Shanxi Provincial People’s Hospital, No. 29, Shuangta East Street, Yingze District, Taiyuan 030012, Shanxi, China  \n2 Department of Medicine, Beijing USCI Medical Laboratory, Beijing 100195, China  \n1 Introduction  \nThyroid cancer ranks as the most prevalent form of malignant endocrine cancer globally, including in China, where its incidence has been gradually rising [1] . Due to reproductive and hormonal factors, the incidence rate among females surpasses that among males by 2.9 times [2]. Papillary thyroid cancer (PTC) accounts for approximately 85% of all thyroid cancers and remains the most frequently encountered differentiated thyroid cancer (DTC) with a favorable prognosis [3] . Patients diagnosed with PTC typically undergo surgical intervention followed by postoperative thyroid-stimulating hormone suppression. The 5-year survival rate after surgery for PTC exceeds 95%, classifying it as a manageable condition. However, a subset of PTC patients with lymph node metastases faces an increased susceptibility to thyroidectomy [4] . Hence, an enhanced comprehension of genetic and clinical characteristics is crucial for future treatments [5] .  \nDespite a signif","cbCaihRuvQfmH5Go","https://ap.wps.com/l/cbCaihRuvQfmH5Go","pdf",1937901,"English","# Abstract\n## Background\n## Patients and Methods\n## Results\n## Conclusion\n# Introduction\n# Materials and Methods\n## Papillary Thyroid Cancer Patients and Samples","[{\"question\":\"How many patients and what gene panel were used to study PTC?\",\"answer\":\"The study analyzed samples from 700 PTC patients using a thyroid cancer panel covering 57 genes to determine mutation frequencies and correlations with clinical data.\"},{\"question\":\"Which mutations were most common in the cohort?\",\"answer\":\"Among the 57 genes examined, BRAF mutations were present in 76.4% of patients, with BRAFV600E representing 90.9% of all BRAF mutations. Other notable driver genes included CHEK2, RET, PIK3CA, and EGFR, and RET fusions were also detected.\"},{\"question\":\"What clinical staging patterns were associated with molecular findings?\",\"answer\":\"Patients younger than 55 years showed a higher tendency toward advanced N staging, and male patients were more likely to have advanced N stages. Higher BRAF allele frequencies correlated with more advanced T and N stages, and a higher frequency of RET fusions correlated with later T and N stages.\"}]","Papillary Thyroid Carcinoma: Correlation Between Molecular and Clinical Features | PDF",1790003576,23]