[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-406192-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-406192-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","papillary-thyroid-carcinoma-and-primary-aldosteronism-a-new-syndrome-or-a-mere-association","Papillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association?","","Primary aldosteronism (PA) is frequently underdiagnosed and may affect up to one-third of patients with hypertension, while thyroid carcinoma is the second most common cancer and papillary thyroid carcinoma (PTC) accounts for 90% of cases. Lymph node metastasis is common in PTC, yet pressure symptoms from invasion of major local veins and the vagus nerve are exceptionally rare. Reports of PTC coexisting with PA are limited, and available literature suggests a possible interplay of genetic and environmental factors.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/papillary-thyroid-carcinoma-and-primary-aldosteronism-a-new-syndrome-or-a-mere-association/406192/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/papillary-thyroid-carcinoma-and-primary-aldosteronism-a-new-syndrome-or-a-mere-association/406192.png","ImageObject",300,407,{"name":42,"@type":43},"Angel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How common is primary aldosteronism in patients with hypertension according to the article?","Question",{"text":63,"@type":64},"The article states that the prevalence could reach one-third in patients with hypertension, and it emphasizes PA is underdiagnosed.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why is the coexistence of PTC and PA considered unusual?",{"text":68,"@type":64},"The article notes that the association between primary hyperaldosteronism and PTC is rare, and that local invasion involving major veins and the vagus nerve is extremely uncommon.",{"name":70,"@type":61,"acceptedAnswer":71},"How many cases of PTC with PA does the article report finding in the literature?",{"text":72,"@type":64},"The authors report finding only 17 cases in the available literature.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},406192,1790716941,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":107,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},687207412472,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2025 December 16; 13(35): 113980  \nDOI: 10.12998/wjcc.v13.i35.113980 ISSN 2307-8960 (online)  \nEDITORIAL  \nPapillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association?  \nHyder Osman Mirghani  \nSpecialty type: Medicine, research and experimental  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C  \nNovelty: Grade C  \nCreativity or Innovation: Grade C  \nScientific Significance: Grade C  \nP-Reviewer: Han JM, PhD, MD, Assistant Professor, China  \nReceived: September 9, 2025  \nRevised: September 20, 2025  \nAccepted: December 15, 2025  \nPublished online: December 16, 2025  \nProcessing time: 99 Days and 1.9 Hours  \nHyder Osman Mirghani, Internal Medicine, University of Tabuk, Tabuk 51941, Saudi Arabia  \nCorresponding author: Hyder Osman Mirghani, MD, Full Professor, Internal Medicine, University of Tabuk, Prince Fahd Bin Sulta, Tabuk 51941, Saudi Arabia.  \n[s.hyder63@hotmail.com](s.hyder63@hotmail.com)  \nAbstract  \nPrimary aldosteronism (PA) is a common disorder, and the condition is underdiagnosed; the prevalence could reach one-third in patients with hypertension, and thyroid carcinoma is the second most common cancer, with papillary thyroid carcinoma (PTC) accounting for 90% of cases. Lymph node metastasis is common in PTC. However, pressure symptoms, including invasion of major local veins and the vagus nerve, are extremely rare. The association between primary hyperaldosteronism and PTC is rare. The interaction between genetic and environmental factors could explain the association. Whether the coexistence of PTC and PA influences the prognosis of PTC is to be explained. The association between PTCand PA with contralateral metastasis, vagus nerve involvement, and invasion to the internal jugular vein is extremely rare. We conducted a comprehensive literature search for relevant articles addressing the possible association of PA and PTC, and we found only 17 cases reported in the literature. The majority were women (10:6 with one study not reporting the gender), the ages ranged from 48 years to 77 years, and perioperative diagnosis was possible in 8 cases. Physicians might need to screen patients with PTC and local invasion for PA.  \nKey Words: Papillary thyroid carcinoma; Primary aldosteronism; Contralateral metastasis; Vagus nerve; Internal jugular vein; Invasion  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 16, 2025  Volume 13  Issue 35   \nMirghani HO. An unusual presentation of PTC and PA  \nCore Tip: Papillary thyroid carcinoma (PTC) and primary aldosteronism are common endocrine disorders. However, their coexistence in the same patient is rare. Local invasion of PTC, including invasion of major local veins and vagus nerve, is extremely rare. This manuscript reviewed the available literature regarding the possible association of PTC and primary aldosteronism and discussed the extremely rare contralateral metastasis and local invasion of PTC to the vagus nerve and internal jugular vein. Our manuscript gave a broader insight into the coexistence of two common endocrine disorders and discussed the risk factors for their association.  \nCitation: Mirghani HO. Papillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association? World J Clin Cases 2025; 13(35): 113980  \nURL: [https://www.wjgnet.com/2307-8960/full/v13/i35/113980.htm](https://www.wjgnet.com/2307-8960/full/v13/i35/113980.htm)  \nDOI: [https://dx.doi.org/10.12998/wjcc.v13.i35.113980](https://dx.doi.org/10.12998/wjcc.v13.i35.113980)  \nPrimary aldosteronism (PA) is a common disorder with a prevalence ","cbCaiiTxFszR0AVE","https://ap.wps.com/l/cbCaiiTxFszR0AVE","pdf",410271,"English","# Abstract\n## Core Tip\n## Citation\n## Keywords\n## Background on PA","[{\"question\":\"How common is primary aldosteronism in patients with hypertension according to the article?\",\"answer\":\"The article states that the prevalence could reach one-third in patients with hypertension, and it emphasizes PA is underdiagnosed.\"},{\"question\":\"Why is the coexistence of PTC and PA considered unusual?\",\"answer\":\"The article notes that the association between primary hyperaldosteronism and PTC is rare, and that local invasion involving major veins and the vagus nerve is extremely uncommon.\"},{\"question\":\"How many cases of PTC with PA does the article report finding in the literature?\",\"answer\":\"The authors report finding only 17 cases in the available literature.\"}]","Papillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association? | PDF",1790564043,18]