[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330692-105":59,"doc-detail-330692-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","papillary-thyroid-cancer-remodels-the-genetic-information-processing-pathways","Papillary Thyroid Cancer Remodels the Genetic Information Processing Pathways","","Papillary thyroid cancer (PTC) remains incompletely understood at the genetic level, even though commonly cited etiologies focus on altered DNA sequence and/or expression of biomarker genes. Tumor heterogeneity and patient-specific factors challenge the universality of single gene biomarkers. Public gene expression profiles from surgically removed PTC tumors were reanalyzed and compared with standard papillary and anaplastic thyroid cancer cell lines.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/papillary-thyroid-cancer-remodels-the-genetic-information-processing-pathways/330692/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/papillary-thyroid-cancer-remodels-the-genetic-information-processing-pathways/330692.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What genetic basis of papillary thyroid cancer does the article address?","Question",{"text":112,"@type":113},"It evaluates how cancer-associated genomic changes remodel genetic information processing, beyond the commonly assumed altered sequence and expression of specific biomarker genes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why do the authors question the fit-for-all gene biomarker model?",{"text":117,"@type":113},"They argue that tumor heterogeneity and patient-specific favoring factors, along with observed transcriptomic differences, limit reliance on uniform biomarker genes for diagnosis and therapy.",{"name":119,"@type":110,"acceptedAnswer":120},"Which major functional pathways are reported as affected in PTC?",{"text":121,"@type":113},"The study reports PTC regulation of numerous genes linked to DNA replication, DNA repair, and transcription, alongside broader changes in pathway networking and transcript abundance control.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330692,1790485510,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Article  \nPapillary Thyroid Cancer Remodels the Genetic Information Processing Pathways  \nDumitru Andrei Iacobas 1, * and Sanda Iacobas 2  \nCitation: Iacobas, D.A.; Iacobas, S. Papillary Thyroid Cancer Remodels the Genetic Information Processing Pathways. Genes 2024, 15, 621 .  \n[https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)genes15050621  \nAcademic Editor: Gokce A. Toruner  \nReceived: 22 April 2024  \nRevised: 10 May 2024  \nAccepted: 13 May 2024  \nPublished: 14 May 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Personalized Genomics Laboratory, Undergraduate Medical Academy, Prairie View A&M University, Prairie View, TX 77446, USA  \n2 Department of Pathology, New York Medical College, Valhalla, NY 10595, USA; [sandaiacobas@gmail.com](sandaiacobas@gmail.com)  \n* Correspondence: [daiacobas@pvamu.edu](daiacobas@pvamu.edu)  \nAbstract: The genetic causes of the differentiated, highly treatable, and mostly non-fatal papillary thyroid cancer (PTC) are not yet fully understood. The mostly accepted PTC etiology blames the altered sequence or/and expression level of certain biomarker genes. However, tumor heterogeneity and the patient’s unique set of favoring factors question the fit-for-all gene biomarkers. Publicly accessible gene expression profiles of the cancer nodule and the surrounding normal tissue from a surgically removed PTC tumor were re-analyzed to determine the cancer-induced alterations of the genomic fabrics responsible for major functional pathways. Tumor data were compared with those of standard papillary and anaplastic thyroid cancer cell lines. We found that PTC regulated numerous genes associated with DNA replication, repair, and transcription. Results further indicated that changes of the gene networking in functional pathways and the homeostatic control of transcript abundances also had major contributions to the PTC phenotype occurrence. The purpose to proliferate and invade the entire gland may explain the substantial transcriptomic differences we detected between the cells of the cancer nodule and those spread in homo-cellular cultures (where they need only to survive) . In conclusion, the PTC etiology should include the complex molecular mechanisms involved in the remodeling of the genetic information processing pathways.  \nKeywords: 8505C anaplastic thyroid cancer cell line; BCPAP papillary thyroid cancer cell line; DNA replication; DNA repair; DNA transcription; evading apoptosis; proliferation; RNA polymerase; TATA-box binding protein associated factors; UBXN1  \n1. Introduction  \nThe American Cancer Society estimates that in 2024, the USA will register 44,020 (31,520 women and 12,500 men) new cases of thyroid cancer (TC), out of which 2170 (1180 females + 990 males) might die because of it [1] . The most lethal form is the nondifferentiated (anaplastic) TC, with only 5 months median survival rate [2] and 8% average 5-year Relative Survival Rate (RSR) when all Surveillance, Epidemiology, and End Results (SEER) stages are considered [1] . The least lethal is the differentiated papillary thyroid carcinoma (PTC) that covers over 8 out of 10 thyroid malignancies, grows slowly, and has a favorable (>99%) 5-year survival prognosis [3,4] . Non-lethal and treatable cancers also include follicular thyroid cancer (RSR = 98%) and medullary thyroid cancer (RSR = 91%) . However, if not treated in time, the differentiated forms can invade adjacent structures and metastasize in neck lymph nodes [5,6] and develop aggressive variants [7,8] .  \nIt is considered that the T1799A point mutation of the BRAF gene is responsible for 45% of the PTC cases [9], albeit mutations of seve","cbCaioqSdsdYesP1","https://ap.wps.com/l/cbCaioqSdsdYesP1","pdf",4041110,24,"English","# Introduction\n## Genetic causes and biomarker utility\n## Study approach and comparative datasets\n# Abstract\n## Purpose and main findings","[{\"question\":\"What genetic basis of papillary thyroid cancer does the article address?\",\"answer\":\"It evaluates how cancer-associated genomic changes remodel genetic information processing, beyond the commonly assumed altered sequence and expression of specific biomarker genes.\"},{\"question\":\"Why do the authors question the fit-for-all gene biomarker model?\",\"answer\":\"They argue that tumor heterogeneity and patient-specific favoring factors, along with observed transcriptomic differences, limit reliance on uniform biomarker genes for diagnosis and therapy.\"},{\"question\":\"Which major functional pathways are reported as affected in PTC?\",\"answer\":\"The study reports PTC regulation of numerous genes linked to DNA replication, DNA repair, and transcription, alongside broader changes in pathway networking and transcript abundance control.\"}]","Papillary Thyroid Cancer Remodels the Genetic Information Processing Pathways | PDF",1789989732]