[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330986-105":59,"doc-detail-330986-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","panoptosis-bridging-apoptosis-pyroptosis-and-necroptosis-in-cancer-progression-and-treatment-cancer-gene-therapy","PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment - Cancer Gene Therapy","","Comprehensive review examining PANoptosis as a convergence of apoptosis, pyroptosis, and necroptosis and its impact on cancer cell death and immune response regulation. The article analyzes molecular pathways and their crosstalk within PANoptosis, highlighting shared components such as caspases and the PANoptosome complex. It surveys roles across multiple cancer types and links PANoptosis with tumor microenvironment dynamics, describing how it shapes immune cell behavior and tumor progression. It further discusses therapeutic advances, including targeting PANoptosis pathways and key signals like caspases, NLRP3, RIPK1, and RIPK3, as well as nanoparticle strategies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/panoptosis-bridging-apoptosis-pyroptosis-and-necroptosis-in-cancer-progression-and-treatment-cancer-gene-therapy/330986/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/panoptosis-bridging-apoptosis-pyroptosis-and-necroptosis-in-cancer-progression-and-treatment-cancer-gene-therapy/330986.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is PANoptosis and why is it important in cancer?","Question",{"text":113,"@type":114},"PANoptosis is a convergence of apoptosis, pyroptosis, and necroptosis that coordinates cell death and immune response regulation. The review links PANoptosis activity with tumorigenesis, patient survival, and potential therapeutic opportunities.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do apoptosis, pyroptosis, and necroptosis interact within PANoptosis?",{"text":118,"@type":114},"The pathways are interconnected and maintain dynamical equilibrium by sharing the deadly protein complex called the PANoptosome. Crosstalk occurs in both execution and regulation of the involved cell-death programs.",{"name":120,"@type":111,"acceptedAnswer":121},"Which molecular targets and strategies are discussed for cancer therapy involving PANoptosis?",{"text":122,"@type":114},"The review highlights targeting key signaling molecules such as caspases, NLRP3, RIPK1, and RIPK3. 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PANoptosis, a convergence of apoptosis, pyroptosis, and necroptosis, plays a crucial role in cell death and immune response regulation. The study delves into the molecular pathways of each cell death mechanism and their crosstalk within PANoptosis, emphasizing the shared components like caspases and the PANoptosome complex. It highlights the significant role of PANoptosis in various cancers, including respiratory, digestive, genitourinary, gliomas, and breast cancers, showing its impact on tumorigenesis and patient survival rates. We further discuss the interwoven relationship between PANoptosis and the tumor microenvironment (TME), illustrating how PANoptosis influences immune cell behavior and tumor progression. It underscores the dynamic interplay between tumors and their microenvironments, focusing on the roles of different immune cells and their interactions with cancer cells. Moreover, the review presents new breakthroughs in cancer therapy, emphasizing the potential of targeting PANoptosis to enhance anti-tumor immunity. It outlines various strategies to manipulate PANoptosis pathways for therapeutic purposes, such as targeting key signaling molecules like caspases, NLRP3, RIPK1, and RIPK3 . The potential of novel treatments like immunogenic |  |\n| --- | --- | --- |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| PANoptosis-initiated therapies and nanoparticle-based strategies is also explored. |  |  |\n|  | Cancer Gene Therapy (2024) 31:970–983; [https://doi.org/10.1038/s41417-024-00765-9](https://doi.org/10.1038/s41417-024-00765-9) |  |\n|  |  |  |\n\nINTRODUCTION  \nNumerous studies have consistently shown that controlling cell proliferation and removing unnecessary or potentially harmful cells is essential in maintaining homeostasis for the growth and development of multicellular organisms in vivo [1] . Programmed cell death (PCD) is an effective mechanism for regulating these processes, designed to actively sculpt, control, and aid in the development and survival of the body [2] . PCD encompasses both classical apoptosis within the context of developmental and tissue homeostasis, as well as alternative forms that arise in response to exogenous or endogenous microenvironment perturbations, such as apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, and others [3] .  \nThe study of the most classical and well-defined PCD pathways of pyroptosis, apoptosis, and necroptosis, and most importantly, the interaction between these three pathways, has led to the establishment and development of the concept of‘ PANoptosis’. Evidence for PANoptosis was first provided in a study of influenza A virus (IAV)-infected macrophages, which demonstrated that activation of caspase-1, caspase-3, and caspase-8, as well as phosphorylation of MLKL, were key molecular events in pyroptosis, apoptosis, and necroptosis [4] . It is worth noting that PANoptosis has key features of the above  \npathways, but cannot be explained by any one of them alone. Rather, they are interconnected and maintain dynamical equilibrium by sharing a deadly protein complex, namely‘ PANoptosome’, which is thought to be a platform that can engage multiple modes of cell death [5] . As such, significant crosstalk occurs in the execution and regulation of the numerous pathways in PANoptosis.  \nRecent studies have focused on the complex molecular mechanisms underlying PANoptosis and its implications in human diseases, particularly canc","cbCaigij8jF9F8Ov","https://ap.wps.com/l/cbCaigij8jF9F8Ov","pdf",2260050,14,"English","# Introduction\n## Programmed cell death and PANoptosis concept\n# PANoptosis mechanisms and molecular crosstalk\n## Shared components: caspases and PANoptosome complex\n# PANoptosis roles in cancers and tumor microenvironment\n## Immune regulation and tumor progression\n# Therapeutic targeting of PANoptosis\n## Strategies: key signaling molecules and nanoparticle approaches","[{\"question\":\"What is PANoptosis and why is it important in cancer?\",\"answer\":\"PANoptosis is a convergence of apoptosis, pyroptosis, and necroptosis that coordinates cell death and immune response regulation. The review links PANoptosis activity with tumorigenesis, patient survival, and potential therapeutic opportunities.\"},{\"question\":\"How do apoptosis, pyroptosis, and necroptosis interact within PANoptosis?\",\"answer\":\"The pathways are interconnected and maintain dynamical equilibrium by sharing the deadly protein complex called the PANoptosome. Crosstalk occurs in both execution and regulation of the involved cell-death programs.\"},{\"question\":\"Which molecular targets and strategies are discussed for cancer therapy involving PANoptosis?\",\"answer\":\"The review highlights targeting key signaling molecules such as caspases, NLRP3, RIPK1, and RIPK3. It also discusses PANoptosis-initiated therapies and nanoparticle-based strategies to enhance anti-tumor immunity.\"}]","PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment - Cancer Gene Therapy | PDF",1789990998,35]