[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-461187-105":59,"doc-detail-461187-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","panhypopituitarism-secondary-to-a-central-nervous-system-germinoma","Panhypopituitarism Secondary to a Central Nervous System Germinoma","","Open access case report describing germ cell tumours and their impact on pituitary function, presenting a young adult with endocrinopathy as the first sign. Explains germ cell tumour biology, broad histologic classification into seminomatous and non-seminomatous types, and the role of tumour markers and imaging in diagnosis. Includes a clinical case of a 22-year-old male with fatigue, recurrent syncope, weight loss, and dehydration, progressing through initial examination and laboratory findings.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/panhypopituitarism-secondary-to-a-central-nervous-system-germinoma/461187/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/panhypopituitarism-secondary-to-a-central-nervous-system-germinoma/461187.png","ImageObject",300,407,{"name":92,"@type":93},"Stanley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the central clinical point of this case report?","Question",{"text":112,"@type":113},"Intracranial germ cell tumours should be considered in young adults admitted with endocrinopathy as an initial presentation, given their ability to disrupt pituitary function.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How are germ cell tumours classified in the report?",{"text":117,"@type":113},"They are broadly classified into seminomatous (germinomatous) and non-seminomatous (non-germinomatous) types, which differ in pathology, treatment sensitivity, and tumour marker profiles.",{"name":119,"@type":110,"acceptedAnswer":120},"What diagnostic elements does the report emphasize?",{"text":121,"@type":113},"Accurate diagnosis relies on imaging, histopathology, and tumour marker assessment, with AFP and β-HCG highlighted as critical for diagnosis, risk stratification, and monitoring response.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461187,1791169971,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336477405376,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Review began 11/11/2025  \nReview ended 12/05/2025  \nPublished 12/10/2025  \n© Copyright 2025  \nHassanes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98887  \nOpen Access Case Report  \nPanhypopituitarism Secondary to a Central Nervous System Germinoma  \nSomia Hassanes 1 , Eboh Cecil 1, Betsy Francis 1  \n1. Medicine, University Hospitals Sussex NHS Foundation Trust, Chichester, GBR Corresponding author: Somia Hassanes, [dr_su_maya@outlook.com](dr_su_maya@outlook.com)  \nAbstract  \nGerm cells are the reproductive cells in a foetus which later develop into sperm in the testicles or unfertilized eggs in the ovaries. They occur in the gonads (testis and ovaries) but can also occur elsewhere in the body, including intracranially. In this case, these tumours can affect the function of the pituitary gland, causing different endocrinological conditions. Understanding the aetiology, classification, and clinical behaviour of germ cell tumours is essential for timely diagnosis, appropriate treatment, and prognostication, given the spectrum of entities encompassed by this group and their variable therapeutic sensitivity and outcomes. This case report highlights the importance of considering intracranial germ cell tumours in a young adult admitted with endocrinopathy as the first presentation.  \nCategories: Neurology, Oncology, Endocrinology/Diabetes/Metabolism  \nKeywords: central diabetes insipidus (cdi), germinoma, hypopituitarism (hp), intracranial germ cell tumors, pineal germinoma, suprasellar tumour  \nIntroduction  \nGerm cell tumours (GCTs) are neoplasms arising from primordial germ cells that fail to complete their normal migration or differentiation during embryogenesis [1] . While they most commonly develop in the gonads (testes and ovaries), extragonadal GCTs can occur along midline structures, including themediastinum, retroperitoneum, and central nervous system (CNS) [1,2] . The pathogenesis of extragonadal GCTs is thought to involve ectopic germ cells that persist along their migratory pathway, ultimately giving rise to neoplasms in aberrant locations [1] .  \nHistologically, GCTs are broadly classified into seminomatous (germinomatous) and non-seminomatous (non-germinomatous) types [3] . Seminomatous tumours are characterised by a uniform population of undifferentiated germ cells, clear cytoplasm, and a prominent lymphocytic infiltrate, and are highly sensitive to radiotherapy and chemotherapy [3] . Non-germinomatous GCTs often secrete tumour markers such as alpha-fetoprotein (AFP) or beta-human chorionic gonadotropin (β-HCG) and typically require multimodal therapy due to relative resistance to single-modality treatment [4] .  \nGCTs display distinct epidemiological patterns. Testicular GCTs are the most common malignancy in young adult males, whereas ovarian GCTs are rare and usually present in children or adolescents [1,2] . Extragonadal GCTs account for fewer than 10% of all GCTs, with the mediastinum being the most frequent site, followed by retroperitoneal and CNS locations [1,5] . Clinical presentation varies with tumour site and histology, ranging from painless masses or abdominal distension to systemic manifestations, including hormonal dysfunction or paraneoplastic syndromes [1,3] .  \nAccurate diagnosis relies on imaging, histopathology, and tumour marker assessment [3,4] . Tumour markers, particularly AFP and β-HCG, are critical for diagnosis, risk stratification, and monitoring of treatment response, especially in non-seminomatous tumours [3] . Management strategies are tailored according to tumour location, histology, and stage, and typically involve surgery, chemotherapy, and radiotherapy, alone or in combination [4] .  \nCase Presentation  \nA 22-year-old male was brought to the emergency d","cbCaiaHrnyQElIpx","https://ap.wps.com/l/cbCaiaHrnyQElIpx","pdf",12467255,21,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"What is the central clinical point of this case report?\",\"answer\":\"Intracranial germ cell tumours should be considered in young adults admitted with endocrinopathy as an initial presentation, given their ability to disrupt pituitary function.\"},{\"question\":\"How are germ cell tumours classified in the report?\",\"answer\":\"They are broadly classified into seminomatous (germinomatous) and non-seminomatous (non-germinomatous) types, which differ in pathology, treatment sensitivity, and tumour marker profiles.\"},{\"question\":\"What diagnostic elements does the report emphasize?\",\"answer\":\"Accurate diagnosis relies on imaging, histopathology, and tumour marker assessment, with AFP and β-HCG highlighted as critical for diagnosis, risk stratification, and monitoring response.\"}]","Panhypopituitarism Secondary to a Central Nervous System Germinoma | PDF",1790760880,53]