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This pooled analysis summarizes clinical characteristics and outcomes of metastatic melanoma to the ampulla and evaluates how surgery may influence prognosis. Data combined a reported institutional case with sporadic PubMed/MEDLINE reports from 1996–2023. Fourteen patients were included; jaundice was most common, and most had concomitant metastases. Pancreaticoduodenectomy with subsequent chemotherapy showed improved survival.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pancreaticoduodenectomy-for-metastatic-melanoma-to-the-ampulla-of-vater-pooled-cases-analysis/433551/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pancreaticoduodenectomy-for-metastatic-melanoma-to-the-ampulla-of-vater-pooled-cases-analysis/433551.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How rare is metastatic melanoma to the ampulla of Vater, and what is the study goal?","Question",{"text":112,"@type":113},"Metastatic melanoma to the ampulla of Vater is described as rare. The study aims to summarize patient characteristics and outcomes and to highlight the impact of surgery on prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What were the main clinical findings in the pooled cases?",{"text":117,"@type":113},"Fourteen patients were enrolled. Jaundice was the most common symptom (86%). Most primary melanomas were cutaneous, and 82% had concomitant metastases at diagnosis, commonly involving the brain, lungs, and liver.",{"name":119,"@type":110,"acceptedAnswer":120},"Did pancreaticoduodenectomy and chemotherapy improve survival?",{"text":121,"@type":113},"Among reported cases, pancreaticoduodenectomy was performed in five patients. Wide excision of the primary lesion and chemotherapy significantly improved survival, and the study concludes there may be a trend toward better outcomes with pancreaticoduodenectomy followed by chemotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},433551,1791206498,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","J Chin MedAssoc  \nOriginal article  \nPancreaticoduodenectomy for metastatic melanoma to the ampulla of Vater: a pooled cases analysis  \nChieh-Ning Hsia,b, Shin-E. Wanga,b, Bor-Shiuan Shyra,b, Shih-Chin Chena,b, Yi-Ming Shyra,b, Bor-Uei Shyra,b,*  \naDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bTherapeutic and Research Center of Pancreatic Cancer, Taipei Veterans General Hospital and National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC  \nAbstract  \nBackground: Metastatic melanoma of the ampulla of Vater is rare. The purpose of this study was to summarize the characteristics and outcomes of metastatic melanoma in the ampulla of Vater and highlight the impact of surgery on the prognosis of patients with metastatic melanoma.  \nMethods: Pooled data from a case encountered at our institution and from all sporadic cases published on PubMed and MEDLINE between 1996 and 2023 were analyzed.  \nResults: Fourteen patients with metastatic melanoma in the ampulla of Vater were enrolled. Ten (73%) of primary melanomas were cutaneous and two were mucosal. Jaundice was the most common symptom (86%) . The size of metastatic melanoma to the ampulla ranged from 1.5 to 8 cm, with a median of 2.75 cm. Concomitant metastasis to other organs occurred in 82% of the patients at the time of diagnosis, most commonly in the brain, lungs, and liver (36% each) . Among the reported cases, pancreaticoduodenectomy was performed in five patients. The overall 1-year survival rate was 27.3%, with a median survival of 4 months. Wide excision of the primary lesion and chemotherapy significantly improved survival rates (50% vs. 0%, p = 0.048) .  \nConclusion: There may be a trend toward improved survival in patients undergoing pancreaticoduodenectomy followed by chemotherapy. Given the availability of effective systemic therapies, metastatic melanoma of the ampulla of Vater does not necessarily preclude major surgeries.  \nKeywords: Ampulla of Vater; MEDLINE; Melanoma; Pancreaticoduodenectomy; Survival rate  \n[www.ejcma.org](www.ejcma.org) 561  \n\u003Cz10.1097/JCMA.0000000000001185>  \nHsi et al. J Chin MedAssoc  \nLay Summary: Melanoma with distant metastasis in the abdominal cavity most commonly affects the liver and the gastrointestinal tract, while metastasis to the ampulla of Vater is rare. Data of metastatic melanoma to the ampulla were collected from our institution and literature reports. Jaundice was the most common symptom. The size of metastatic melanoma to the ampulla ranged from 1.5 cm to 8 cm, with a median of 2.75 cm. Concomitant metastasis to other organs occurred in 82% of the patients at the time of diagnosis, most commonly in the brain, lungs, and liver, 36% each. The overall 1-year survival rate was 27.3%, with a median survival of 4 months. Wide excision of the primary lesion and chemotherapy significantly improved survival rates. There is a trend toward improved survival in patients undergoing pancreaticoduodenectomy followed by chemotherapy. Given the availability of effective systemic therapies, metastatic melanoma of the ampulla of Vater does not necessarily preclude major surgeries.  \n1. INTRODUCTION  \nMelanoma, the leading cause of skin cancer-related deaths, encompasses a diverse spectrum of malignant melanocytic proliferations.1 Melanoma with distant metastasis in the abdominal cavity most commonly affects the liver and the gastrointestinal tract,2 while metastasis to the ampulla of Vater is uncommon with a dismal prognosis.3 As various therapeutic agents advance, the effective treatment of patients with distant melanoma metastasis has become a reality, significantly enhancing their quality of life.4 However, the optimal therapeutic approach for metastatic melanoma to the ampulla of Vater remains uncertain, given the rarity of such metastatic lesions. The appropriateness of aggressive surgical strategy, such as pancreaticoduodenectomy, remains a topic of uncertainty in this con","cbCaib6KfdtUdpRv","https://ap.wps.com/l/cbCaib6KfdtUdpRv","pdf",909565,"English","# Introduction\n## Methods\n## Results\n## Conclusion","[{\"question\":\"How rare is metastatic melanoma to the ampulla of Vater, and what is the study goal?\",\"answer\":\"Metastatic melanoma to the ampulla of Vater is described as rare. The study aims to summarize patient characteristics and outcomes and to highlight the impact of surgery on prognosis.\"},{\"question\":\"What were the main clinical findings in the pooled cases?\",\"answer\":\"Fourteen patients were enrolled. Jaundice was the most common symptom (86%). Most primary melanomas were cutaneous, and 82% had concomitant metastases at diagnosis, commonly involving the brain, lungs, and liver.\"},{\"question\":\"Did pancreaticoduodenectomy and chemotherapy improve survival?\",\"answer\":\"Among reported cases, pancreaticoduodenectomy was performed in five patients. Wide excision of the primary lesion and chemotherapy significantly improved survival, and the study concludes there may be a trend toward better outcomes with pancreaticoduodenectomy followed by chemotherapy.\"}]","Pancreaticoduodenectomy for metastatic melanoma to the ampulla of Vater - pooled cases analysis | PDF",1790664554,18]