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A retrospective cadaveric analysis examined prevalence and histopathological features across 85 specimens from elderly individuals. Five PNEMT cases (5.9%) were identified with strongly chromogranin A and synaptophysin-positive, predominantly glucagon-expressing, grade 1 lesions showing minimal Ki-67 proliferation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pancreatic-neuroendocrine-microtumors-in-the-elderly-a-retrospective-study-using-cadaveric-pancreatic-tissue/406565/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pancreatic-neuroendocrine-microtumors-in-the-elderly-a-retrospective-study-using-cadaveric-pancreatic-tissue/406565.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are pancreatic neuroendocrine microtumors (PNEMTs) and why focus on elderly cases?","Question",{"text":112,"@type":113},"PNEMTs are small (\u003C 5 mm), nonfunctioning, well-differentiated neuroendocrine neoplasms, usually discovered incidentally. Evidence about their occurrence in elderly individuals, especially in cadaveric studies, is limited.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study conducted to assess PNEMT prevalence?",{"text":117,"@type":113},"The study retrospectively analyzed 85 pancreatic specimens (ages 58–109) obtained from cadavers for anatomical education and research. Paraffin sections from the pancreatic head, body, and tail were processed for histological and immunohistochemical evaluation.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings regarding PNEMT frequency and pathology?",{"text":121,"@type":113},"Five PNEMT cases were identified (5/85, 5.9%), all solitary and \u003C 5 mm. Tumors showed strong chromogranin A and synaptophysin positivity, predominantly glucagon expression, and minimal Ki-67 proliferative activity consistent with non-functioning, glucagon-producing grade 1 PNEMTs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406565,1790864422,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},5909890329169,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2025 December 15; 17(12): 113198  \nDOI: 10.4251/wjgo.v17.i12.113198 ISSN 1948-5204 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nPancreatic neuroendocrine microtumors in the elderly: A retrospective study using cadaveric pancreatic tissue  \nTing Yang, Ke Ren, Xiang-Quan Chen, Taku Toriumi, Yutaro Natsuyama, Jun Li, Aoi Sukeda, Toshitaka Nagao, Shuang-Qin Yi  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade B, Grade C  \nNovelty: Grade B, Grade B, Grade C  \nCreativity or Innovation: Grade A, Grade B, Grade C  \nScientific Significance: Grade B, Grade B, Grade C  \nP-Reviewer: Liu Z, PhD, Associate Chief Physician, Associate Professor, China; Lv CM, Academic Fellow, China  \nReceived: August 20, 2025  \nRevised: September 18, 2025  \nAccepted: October 30, 2025  \nPublished online: December 15, 2025  \nProcessing time: 114 Days and 4.7 Hours  \nTing Yang, Shuang-Qin Yi, Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo 116-8551, Japan  \nKe Ren, Xiang-Quan Chen, Faculty of Physical Education, Qujing Normal University, Qujing 655000, Yunnan Province, China  \nTaku Toriumi, Department of 1st Anatomy, Nippon Dental University School of Life Dentistry at Niigata, Niigata 951-8037, Japan  \nYutaro Natsuyama, Department of Anatomy, Tokyo Medical University, Tokyo 160-0022, Japan  \nJun Li, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China  \nAoi Sukeda, Toshitaka Nagao, Department of Anatomic Pathology, Tokyo Medical University Hospital, Tokyo 160-0023, Japan  \nCo-first authors: Ting Yang and Ke Ren.  \nCorresponding author: Shuang-Qin Yi, MD, PhD, Professor, Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashiogu, Arakawa-Ku, Tokyo 116-8551, [Japan.](Japan. yittmniu@tmu.ac.jp)[ yittmniu@tmu.ac.jp](Japan. yittmniu@tmu.ac.jp)  \nAbstract  \nBACKGROUND  \nPancreatic neuroendocrine microtumors (PNEMTs) are small (\u003C 5 mm), nonfunctioning, well-differentiated neuroendocrine neoplasms. Although they are rare, they are not invariably benign. PNEMTs are typically discovered incidentally during autopsy. However, data regarding the occurrence of PNEMTs in the elderly population, particularly those identified incidentally in cadaveric studies, remain limited.  \nAIM  \nTo investigate the prevalence and histopathological characteristics of PNEMTs in elderly individuals by analyzing cadaveric pancreatic tissues.  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 15, 2025  Volume 17  Issue 12   \nYang T et al. PNEMTs in the elderly  \nMETHODS  \nWe conducted a retrospective analysis of 85 pancreatic specimens (age range: 58-109 years) obtained from cadavers for anatomical education and research at the Department of Life Dentistry, Nippon Dental University. Paraffin sections of the pancreatic head, body, and tail were prepared for histological and immunohistochemical analysis.  \nRESULTS  \nFive cases with PNEMTs (5/85, 5.9%; male, n = 33; female, n = 52; mean age: 85.8 ± 12.1 years) were identified. The tumors were solitary, well circumscribed, and located within the pancreatic parenchyma (body: n = 4; tail: n = 1), and all were \u003C 5 mm (range: 0.54-2.20 mm) in size. All tumors showed strong chromogranin A and synaptophysin positivity, and were predominantly glucagon (GLU)-positive. Ki-67 immunostaining indicated minimal proliferative activity; therefore, these tumors were considered non-functioning, GLU-producing, well-differ","cbCaioBTABX1vI2a","https://ap.wps.com/l/cbCaioBTABX1vI2a","pdf",39473340,11,"English","# Background\n# Aim\n# Methods\n# Results\n# Conclusion\n# Key Words","[{\"question\":\"What are pancreatic neuroendocrine microtumors (PNEMTs) and why focus on elderly cases?\",\"answer\":\"PNEMTs are small (\\u003c 5 mm), nonfunctioning, well-differentiated neuroendocrine neoplasms, usually discovered incidentally. Evidence about their occurrence in elderly individuals, especially in cadaveric studies, is limited.\"},{\"question\":\"How was the study conducted to assess PNEMT prevalence?\",\"answer\":\"The study retrospectively analyzed 85 pancreatic specimens (ages 58–109) obtained from cadavers for anatomical education and research. Paraffin sections from the pancreatic head, body, and tail were processed for histological and immunohistochemical evaluation.\"},{\"question\":\"What were the key findings regarding PNEMT frequency and pathology?\",\"answer\":\"Five PNEMT cases were identified (5/85, 5.9%), all solitary and \\u003c 5 mm. Tumors showed strong chromogranin A and synaptophysin positivity, predominantly glucagon expression, and minimal Ki-67 proliferative activity consistent with non-functioning, glucagon-producing grade 1 PNEMTs.\"}]","Pancreatic neuroendocrine microtumors in the elderly - A retrospective study using cadaveric pancreatic tissue | PDF",1790566469,28]