[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-353977-105":59,"doc-detail-353977-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pancreatic-cancer-associated-myofibroblasts-a-review","Pancreatic cancer-associated myofibroblasts - a review","","Pancreatic cancer is a deadly disease with no effective clinical therapy, making new treatment strategies urgent. The tumor contains a prominent stromal compartment where pancreatic cancer-associated myofibroblasts act as major extracellular matrix producers. Studies indicate multifaceted roles in proliferation, invasiveness, and prognostic biomarker potential, including links to stromal collagen content and presence in precancerous lesions. However, myofibroblast depletion can worsen outcomes in vivo, leaving their exact disease function unresolved. This review synthesizes origin, function, biomarker potential, and heterogeneity to clarify their role in disease progression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pancreatic-cancer-associated-myofibroblasts-a-review/353977/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pancreatic-cancer-associated-myofibroblasts-a-review/353977.png","ImageObject",300,407,{"name":92,"@type":93},"Sophia Brooks","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are pancreatic cancer-associated myofibroblasts considered important in pancreatic cancer?","Question",{"text":112,"@type":113},"They are key extracellular matrix producers within the stromal compartment and have been linked to promoting cancer cell proliferation and invasiveness, as well as prognostic biomarker potential.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What additional roles have myofibroblasts been reported to play beyond matrix secretion?",{"text":117,"@type":113},"Recent studies describe multiple functions, including supporting cancer cell proliferation and invasiveness and contributing to features such as chemoresistance.",{"name":119,"@type":110,"acceptedAnswer":120},"Why does the review highlight an apparent paradox regarding myofibroblast depletion?",{"text":121,"@type":113},"Although myofibroblasts drive pro-tumor stromal effects in desmoplastic reaction, depletion has shown detrimental effects on disease outcome in at least one in vivo study, leaving their precise role unclear.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},353977,1790195285,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},962084925636,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Ivyspring  \nInternational Publisher  \nInternationalJournal of Biological Sciences  \n2026; 22(6): 2774-2785. doi: 10.7150/ijbs.121234  \nReview  \nPancreatic cancer-associated myofibroblasts: a review  \nMarcin Banacki, Iwona Inkielewicz-Stepniak􀀍  \nDepartment of Pharmaceutical Pathophysiology, Medical University of Gdańsk, Gdańsk, Poland.  \n􀀍 Corresponding author: Iwona Inkielewicz-Stepniak, Email: [iwona.inkielewicz-stepniak@gumed.edu.pl](iwona.inkielewicz-stepniak@gumed.edu.pl).  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [https://ivyspring.com/terms](https://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2025.07.08; Accepted: 2025.12.27; Published: 2026.02.18  \nAbstract  \nPancreatic cancer is a very deadly disease, with no effective therapy currently employed in clinical practice, highlighting the urgent need for new therapeutic strategies. Cancer cells represent a minority within the pancreatic tumor, which is characterized by a pronounced stromal compartment. As fibrosis is characteristic of pancreatic ductal adenocarcinoma, the cell population of particular interest is the pancreatic cancer-associated myofibroblast population, observed to be the main extracellular matrix producers. Recent studies revealed a plurality of myofibroblast functions in the pancreatic tumor, beyond their role in matrix secretion: they were noted to promote cancer cell proliferation and invasiveness in in vitro and in vivo studies, and have been described as potential prognostic biomarkers, along with stromal collagen content. Moreover, myofibroblasts were found in precancerous pancreatic lesions, and may thus be involved in pancreatic carcinogenesis. Paradoxically, depletion of myofibroblasts had detrimental effects on the outcome in an in vivo study, and their precise role in the disease remains unclear. This review summarizes for the first time studies on pancreatic cancer-associated myofibroblasts, focusing on the origin, function, biomarker potential, and heterogeneity of these cells in the pancreatic tumor, aiming to elucidate their role in pancreatic cancer progression.  \nKeywords: Pancreatic cancer, myofibroblast, fibrosis, microenvironment, stellate cell, extracellular matrix  \nBackground  \nThe cellular portion of the tumor microenvironment consists of cells belonging to a number of cell types beyond cancer cells, including various immune cells, endothelial cells, and fibroblasts [1] . These cells perform a plurality of functions within the tumor, inducing (or inhibiting) angiogenesis, immune tolerance or cancer cell proliferation [1] . Microenvironment cells are also responsible for the secretion of extracellular matrix (ECM) proteins, which form the acellular portion of the microenvironment [1] . This phenomenon, dubbed“desmoplastic reaction”, furthers the pro-tumor effects of the microenvironment, inducing angiogenesis [2] or serving as a nutritional source for cancer cells [3] . Cancer-associated fibroblasts are known as primary producers of ECM in tumors [4] .  \nPancreatic adenocarcinoma is a yet-unbeatable disease, a characteristic of which is its low 5-year survival rate [5] . Dense stroma is a characteristic of the pancreatic tumor [6], decreasing drug penetration  \nand thus, diminishing therapy effectiveness [7] . As such, fibroblasts present within the tumor’s microenvironment are of interest from both the clinical and biological perspective. Emerging evidence points to the presence of three main fibroblast types associated are distinguished in this disease: inflammatory cancer-associated fibroblasts, which are characterized by their low expression of alpha-smooth muscle actin (αSMA), secrete proinflammatory cytokines, such as IL-6 [8]; antigen-presenting cancerassociated fibroblasts, which express HLA-II-group antigen-presenting molecule","cbCaifpxZyhRU8TR","https://ap.wps.com/l/cbCaifpxZyhRU8TR","pdf",1812516,12,"English","# Abstract\n# Background\n## Tumor microenvironment and desmoplastic reaction\n## Fibroblast types in pancreatic adenocarcinoma\n## Nomenclature and functional definition of myofibroblasts\n# Origins of pancreatic adenocarcinoma-associated myofibroblasts\n# Sources of pancreatic adenocarcinoma-associated myofibroblasts","[{\"question\":\"Why are pancreatic cancer-associated myofibroblasts considered important in pancreatic cancer?\",\"answer\":\"They are key extracellular matrix producers within the stromal compartment and have been linked to promoting cancer cell proliferation and invasiveness, as well as prognostic biomarker potential.\"},{\"question\":\"What additional roles have myofibroblasts been reported to play beyond matrix secretion?\",\"answer\":\"Recent studies describe multiple functions, including supporting cancer cell proliferation and invasiveness and contributing to features such as chemoresistance.\"},{\"question\":\"Why does the review highlight an apparent paradox regarding myofibroblast depletion?\",\"answer\":\"Although myofibroblasts drive pro-tumor stromal effects in desmoplastic reaction, depletion has shown detrimental effects on disease outcome in at least one in vivo study, leaving their precise role unclear.\"}]","Pancreatic cancer-associated myofibroblasts - a review | PDF",1790108305]