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This study systematically analyzes FANCD2 expression, prognostic value, clinicopathological associations, and immune cell infiltration using bioinformatics methods. Results show FANCD2 is upregulated across multiple common cancers and that higher levels predict poor overall survival via Cox regression and Kaplan–Meier. Reduced FANCD2 DNA methylation is inversely related to expression. FANCD2 mutations associate with survival outcomes in specific tumor types, with links to immune checkpoints, TMB, and MSI. Enrichment suggests involvement in the Fanconi anemia pathway and cell-cycle regulation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pancancer-analysis-of-the-prognostic-and-immunological-role-of-fancd2-a-potential-target-for-carcinogenesis-and-survival/330200/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pancancer-analysis-of-the-prognostic-and-immunological-role-of-fancd2-a-potential-target-for-carcinogenesis-and-survival/330200.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main aim of this pan-cancer study on FANCD2?","Question",{"text":112,"@type":113},"To evaluate FANCD2 expression patterns, prognostic significance, associations with clinicopathological parameters, and immune cell infiltration across multiple cancer types.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do higher FANCD2 levels relate to patient outcomes?",{"text":117,"@type":113},"Higher FANCD2 expression is associated with worse overall survival, supported by Cox regression and Kaplan–Meier analyses.",{"name":119,"@type":110,"acceptedAnswer":120},"What molecular and immunological features are linked to FANCD2?",{"text":121,"@type":113},"FANCD2 shows correlations with DNA methylation status, genetic alterations (especially mutations), immune checkpoint gene expression, tumor mutation burden (TMB), and microsatellite instability (MSI).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330200,1790480383,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","Zhao et al. BMC Medical Genomics (2024) 17:69 [https://doi.org/10.1186/s12920-024-01836-4](https://doi.org/10.1186/s12920-024-01836-4)  \nBMC Medical Genomics  \n RESEARCH Open Access  \nPancancer analysis of the prognostic  \nand immunological role ofFANCD2: a potential target for carcinogenesis and survival  \nZedan Zhao1,2†, Ruyu Wang4†, Ruixue Wang5, Jialing Song1,2, Fengjun Ma5, Huafeng Pan6, Cuiyun Gao1,2, Deqiang Wang1*, Xuemei Chen3* and Xiangzhen Fan 1*  \nAbstract  \nRecent evidence has shed light on the significant role of FANCD2 in cancer initiation, development, and progression. However, a comprehensive pan-cancer analysis of FANCD2 has been lacking. In this study, we have conducted a thorough investigation into the expression profiles and prognostic significance of FANCD2, as well as its correlation with clinicopathological parameters and immune cell infiltration, using advanced bioinformatic techniques. The results demonstrate that FANCD2 is significantly upregulated in various common cancers and is associated with prognosis. Notably, higher expression levels of FANCD2 are linked to poor overall survival, as indicated by Cox regression and Kaplan-Meier analyses. Additionally, we have observed a decrease in the methylation of FANCD2 DNA in some cancers, and this decrease is inversely correlated with FANCD2 expression. Genetic alterations in FANCD2 predominantly manifest as mutations, which are associated with overall survival, disease-specific survival, disease-free survival, and progression-free survival in certain tumor types. Moreover, FANCD2 exhibits a strong correlation with infiltrating cell levels, immune checkpoint genes, tumor mutation burden (TMB), and microsatellite instability (MSI) . Enrichment analysis further highlights the potential impact of FANCD2 on Fanconi anemia (FA) pathway and cell cycle regulation. Through this comprehensive pan-cancer analysis, we have gained a deeper understanding of the functions of FANCD2 in oncogenesis and metastasis across different types of cancer.  \nKeywords FANCD2, Pan-cancer analysis, Prognosis, Immune infiltration, Genetic alteration, Enrichment analysis  \n†Zedan Zhao and Ruyu Wang are co-first authors.  \n*Correspondence: Deqiang Wang [Wdqbz@163.com](Wdqbz@163.com)[ ](Wdqbz@163.com)Xuemei Chen [cacy0109@163.com](cacy0109@163.com)[ ](cacy0109@163.com)Xiangzhen Fan [643355196@qq.com](643355196@qq.com)  \n1 Department of Rehabilitation Medicine, Binzhou Medical University Hospital, Binzhou, Shandong 256603, China  \n2 School of Rehabilitation Medicine, Binzhou Medical University, Yantai, Shandong 264003, China  \n3 Department of Obstetrics, Binzhou Medical University Hospital, Binzhou, Shandong 256603, China  \n4 School of clinical medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330004, China  \n5 Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China  \n6 Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China  \n© The Author(s) 2024, corrected publication 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedica","cbCaibUU33AQtegX","https://ap.wps.com/l/cbCaibUU33AQtegX","pdf",12764315,17,"English","# Abstract\n# Introduction","[{\"question\":\"What is the main aim of this pan-cancer study on FANCD2?\",\"answer\":\"To evaluate FANCD2 expression patterns, prognostic significance, associations with clinicopathological parameters, and immune cell infiltration across multiple cancer types.\"},{\"question\":\"How do higher FANCD2 levels relate to patient outcomes?\",\"answer\":\"Higher FANCD2 expression is associated with worse overall survival, supported by Cox regression and Kaplan–Meier analyses.\"},{\"question\":\"What molecular and immunological features are linked to FANCD2?\",\"answer\":\"FANCD2 shows correlations with DNA methylation status, genetic alterations (especially mutations), immune checkpoint gene expression, tumor mutation burden (TMB), and microsatellite instability (MSI).\"}]","Pancancer analysis of the prognostic and immunological role of FANCD2 - a potential target for carcinogenesis and survival | PDF",1789987656,43]