[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331542-105":59,"doc-detail-331542-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pan-immune-inflammation-value-as-a-novel-prognostic-biomarker-for-digestive-system-cancers-a-meta-analysis","Pan-immune-inflammation value as a novel prognostic biomarker for digestive system cancers - a meta-analysis","","Digestive system cancers create major global health burdens with persistently high incidence and mortality. Inflammation is central to cancer progression, motivating the search for dependable prognostic indicators. This meta-analysis assesses the pan-immune-inflammation value (PIV) as a measure of immune-inflammatory response and evaluates whether higher PIV corresponds to worse survival across digestive system malignancies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-immune-inflammation-value-as-a-novel-prognostic-biomarker-for-digestive-system-cancers-a-meta-analysis/331542/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-immune-inflammation-value-as-a-novel-prognostic-biomarker-for-digestive-system-cancers-a-meta-analysis/331542.png","ImageObject",300,407,{"name":92,"@type":93},"Seraphina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biomarker does the meta-analysis focus on?","Question",{"text":112,"@type":113},"The study evaluates the pan-immune-inflammation value (PIV) as a prognostic biomarker reflecting immune-inflammatory response in digestive system cancers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the evidence gathered and analyzed?",{"text":117,"@type":113},"A meta-analysis was conducted using search results up to June 2024, extracting PIV data and hazard ratios for multiple survival outcomes using STATA 14.0.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the prognostic implication of high PIV levels?",{"text":121,"@type":113},"High PIV levels are associated with significantly poorer prognosis, including worse overall survival and other survival endpoints such as PFS, DFS, RFS, and CSS.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331542,1791083156,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165","Yu etal. World Journal of Surgical Oncology (2024) 22:306  \n[https://doi.org/10.1186/s12957-024-03595-z](https://doi.org/10.1186/s12957-024-03595-z)  \nWorld Journal of Surgical Oncology  \nREVIEW Open Access  \nPan-immune-inflammation value as a novel prognostic biomarker for digestive system cancers: a meta-analysis  \nDongli Yu 1†, Jingting Liu2†, Chunyan Meng 1, Baoqing Liu 1 and Jianhua Liao 1*  \nAbstract  \nBackground Digestive system cancers pose a significant global health challenge with high incidence and mortality rates. Inflammation is a key factor in cancer progression, necessitating reliable prognostic indicators. The pan-immune-inflammation value (PIV), as a new biomarker of immune-inflammatory response, has emerged as a potential prognostic biomarker for cancers.  \nMethods We performed a meta-analysis to evaluate the prognostic significance of PIV in digestive system cancers. Our search, up to June 2024, included 20 studies from 19 articles with 5037 patients. We extracted and analyzed data on PIV levels and assessed hazard ratios (HRs) for overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), recurrence-free survival (RFS), and cancer-specific survival (CSS) using STATA 14.0.  \nResults Our analysis found that high PIV levels were significantly associated with poor prognosis in patients with digestive system cancers. Specifically, high PIV was linked to shorter OS (HR = 2 . 039, P \u003C 0. 001), PFS (HR = 1 . 877,  \nP = 0 . 028), DFS (HR = 1 . 624, P = 0 . 005), RFS (HR = 2 . 393, P = 0 . 037), and CSS (HR = 2 . 053, P \u003C 0. 001) . Additionally, the adverse prognostic impact of high PIV on OS was consistent across different cancer types, including digestive tract, colorectal, esophageal, and hepatobiliary pancreatic cancers. Although some heterogeneity was observed, sensitivity and bias analyses confirmed the reliability of these findings.  \nConclusions PIV was a valuable and practical prognostic marker for digestive system cancers, providing significant predictive value across multiple survival metrics. Its simplicity and minimal invasiveness nature support its potential integration into routine clinical practice.  \nKeywords Pan-immune-inflammation value, Cancer, Meta-analysis, Prognosis, Biomarker  \n†Dongli Yu and Jingting Liu contributed equally to this work.  \n*Correspondence: Jianhua Liao [ljhsywzh@163.com](ljhsywzh@163.com)  \n1Department of Surgery, Zhejiang Hospital, 12 Lingyin Road, Zhejiang 310013, China  \n2Department of Health management, Sir Run Run Shaw International Medical Centre, 9 Jingtan Road, Hangzhou 310000, Zhejiang, China  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nYu et al. World Journal of Surgical Oncology (2024) 22:306  \nIntroduction  \nMalignant tumors have long been a major health issue affecting people worldwide. Despite significant advancements in various areas of research in recent years, which have improved the conditions for some individual","cbCaijE5EEO95vdS","https://ap.wps.com/l/cbCaijE5EEO95vdS","pdf",3135680,12,"English","# Abstract\n# Introduction\n## Background and rationale\n## Role of inflammation and immune response","[{\"question\":\"What biomarker does the meta-analysis focus on?\",\"answer\":\"The study evaluates the pan-immune-inflammation value (PIV) as a prognostic biomarker reflecting immune-inflammatory response in digestive system cancers.\"},{\"question\":\"How was the evidence gathered and analyzed?\",\"answer\":\"A meta-analysis was conducted using search results up to June 2024, extracting PIV data and hazard ratios for multiple survival outcomes using STATA 14.0.\"},{\"question\":\"What is the prognostic implication of high PIV levels?\",\"answer\":\"High PIV levels are associated with significantly poorer prognosis, including worse overall survival and other survival endpoints such as PFS, DFS, RFS, and CSS.\"}]","Pan-immune-inflammation value as a novel prognostic biomarker for digestive system cancers - a meta-analysis | PDF",1789993818]