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Despite reports of abnormal expression in several malignancies, the molecular and functional complexity of HOXA9 across cancers remains unclear. This study analyzes HOXA9 across 33 cancer types by integrating large-scale public datasets (GDC-TCGA), defining genetic and epigenetic regulation, mapping downstream pathways, and evaluating clinical relevance in prognosis, stage stratification, immune infiltration, and associations with approved antineoplastic drugs.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-exploration-of-oncogenic-and-clinical-impacts-revealed-that-hoxa9-is-a-diagnostic-indicator-of-tumorigenesis/332166/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-exploration-of-oncogenic-and-clinical-impacts-revealed-that-hoxa9-is-a-diagnostic-indicator-of-tumorigenesis/332166.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological functions does HOXA9 have according to the abstract?","Question",{"text":112,"@type":113},"HOXA9 is described as a crucial HOX-cluster transcription factor involved in embryo implantation, morphogenesis, body axis development, and endothelial cell differentiation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was HOXA9 analyzed across cancers in this study?",{"text":117,"@type":113},"The study performed a comprehensive pan-cancer analysis by integrating large-scale TCGA datasets from public repositories, covering 33 cancer types, and using online tools with experimentally validated observations.",{"name":119,"@type":110,"acceptedAnswer":120},"What clinical or therapeutic significance is attributed to HOXA9?",{"text":121,"@type":113},"HOXA9 shows prognostic relevance across cancer stages, correlates with tumor-infiltrating immune molecules, and its targeting is suggested as a reliable strategy to prevent cancer progression, based on associations with approved antineoplastic drugs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332166,1790491078,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","Clinical and Experimental Medicine (2024) 24:134 [https://doi.org/10.1007/s10238-024-01389-x](https://doi.org/10.1007/s10238-024-01389-x)  \nPan‑cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis  \nU. Sangeetha Shenoy1 · Dhanraj Salur Basavarajappa1 · Shama Prasada Kabekkodu1 · Raghu Radhakrishnan2,3  \nReceived: 1 March 2024 / Accepted: 4 June 2024 / Published online: 21 June 2024 © The Author(s) 2024  \nAbstract  \nHomeodomain transcription factor A9 (HOXA9) is a member of the HOX cluster family of transcription factors that are crucially involved in embryo implantation, morphogenesis, body axis development, and endothelial cell differentiation. Despite numerous reports on its aberrant expression in a few malignancies, the molecular and functional complexity of HOXA9 across cancers remains obscure. We aimed to analyze the dynamic role of HOXA9 across cancers by identifying, analyzing, and understanding its multiple modes of regulation and functional implications and identifying possible therapeutic avenues. We conducted a comprehensive analysis to determine the role of HOXA9 across cancers. This approach involved the integration of large-scale datasets from public repositories such as the Genomic Data Commons, specifically the Cancer Genome Atlas (GDC-TCGA), across 33 different cancer types. The multiple modes of HOXA9 regulation by genetic and epigenetic factors were determined using online tools, which comprised experimentally validated observations. Furthermore, downstream pathways were identified by predicting the targets of HOXA9 and by performing functional enrichment analysis. We also assessed the clinical significance of HOXA9 in terms of prognosis and stage stratification. This study evaluated the correlation between HOXA9 and tumor-infiltrating molecules and discussed its association with therapeutically approved antineoplastic drugs. HOXA9 was significantly upregulated in 9 tumors and downregulated in 2 cancers. The deregulation of HOXA9 is primarily attributed to epigenetic factors, including promoter DNA methylation and noncoding RNAs (ncRNAs) . The HOXA9 transcription factor interacts with PBX/MEIS cofactors and regulates multiple genes involved in cancerassociated EMT, autophagy, the cell cycle, metabolic pathways, Wnt signaling, TGF-β signaling, the AMPK pathway, PI3K/ AKT signaling, and NF-κB signaling, thereby establishing control over downstream mechanisms. Differential expression in various clinical stages across cancers was shown to have prognostic significance and to be correlated with tumor-infiltrating immune molecules. The assessment of the correlation of HOXA9 expression with approved antineoplastic drugs revealed that targeting HOXA9 could be the most reliable strategy for preventing cancer progression. HOXA9 is upregulated in the majority of malignancies and drives cancer progression by regulating multiple signaling mechanisms. Hence, HOXA9 could be a reliable diagnostic indicator and a potential therapeutic candidate for solid cancer types.  \nKeywords HOXA9 · TCGA dataset · Cancer progression · Immune infiltration · Therapeutic drugs  \n* Raghu Radhakrishnan [raghu.ar@manipal.edu](raghu.ar@manipal.edu)  \n1 Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India  \n2 Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India  \n3 Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK  \nAbbreviations  \nGDC Genomic Data Commons  \nTCGA The Cancer Genome Atlas ncRNA Noncoding RNA  \nCRC Colorectal cancer  \nPC Pancreatic cancer  \nPCa Prostate cancer  \nGBM Glioblastoma  \nCSCC Cutaneous squamous cell carcinoma CC Cervical cancer  \nBC Breast cancer  \nNSCLC Non-small cell lung cancer EOC Epithelial ova","cbCaim2HkgzoqpWU","https://ap.wps.com/l/cbCaim2HkgzoqpWU","pdf",8935597,18,"English","# Abstract\n## Study design and data integration\n## HOXA9 regulation and pathway mapping\n## Clinical significance and therapeutic relevance\n# Introduction\n## HOX genes and HOXA9 biological role","[{\"question\":\"What biological functions does HOXA9 have according to the abstract?\",\"answer\":\"HOXA9 is described as a crucial HOX-cluster transcription factor involved in embryo implantation, morphogenesis, body axis development, and endothelial cell differentiation.\"},{\"question\":\"How was HOXA9 analyzed across cancers in this study?\",\"answer\":\"The study performed a comprehensive pan-cancer analysis by integrating large-scale TCGA datasets from public repositories, covering 33 cancer types, and using online tools with experimentally validated observations.\"},{\"question\":\"What clinical or therapeutic significance is attributed to HOXA9?\",\"answer\":\"HOXA9 shows prognostic relevance across cancer stages, correlates with tumor-infiltrating immune molecules, and its targeting is suggested as a reliable strategy to prevent cancer progression, based on associations with approved antineoplastic drugs.\"}]","Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis | PDF",1789997161,45]