[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-345558-105":59,"doc-detail-345558-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pan-cancer-characterization-of-postn-and-its-clinical-and-microenvironmental-associations-in-er-breast-cancer","Pan-cancer characterization of POSTN and its clinical and microenvironmental associations in ER + breast cancer","","Periostin (POSTN) is implicated in the progression of multiple malignancies, yet its pan-cancer landscape and clinical relevance in estrogen receptor (ER)-positive breast cancer remain unclear. The study integrated TIMER2.0, TCGA, GTEx, and GEO to map POSTN expression patterns and links to prognosis, genetic/epigenetic alterations, tumor microenvironment features, and drug-response indicators. In an ER+ cohort, differential expression, immune infiltration, drug–gene associations, and in vitro assays were combined. POSTN correlated with stage, molecular subtypes, macrophage/CAF features, immune-regulatory signatures, and predicted drug sensitivity. Silencing POSTN reduced migration and invasion.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-characterization-of-postn-and-its-clinical-and-microenvironmental-associations-in-er-breast-cancer/345558/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-characterization-of-postn-and-its-clinical-and-microenvironmental-associations-in-er-breast-cancer/345558.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main goal of the study on POSTN in ER+ breast cancer?","Question",{"text":112,"@type":113},"To clarify POSTN’s clinical significance using pan-cancer analyses and to further investigate its association with ER+ breast cancer, including prognosis, tumor microenvironment features, and drug-response indicators.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which public datasets were integrated to evaluate POSTN expression and associations?",{"text":117,"@type":113},"The study integrated TIMER2.0, TCGA, GTEx, and GEO to analyze POSTN expression patterns and their relationships with prognosis, molecular alterations, tumor microenvironment traits, and predicted drug response.",{"name":119,"@type":110,"acceptedAnswer":120},"How did POSTN relate to the tumor microenvironment in ER+ breast cancer?",{"text":121,"@type":113},"POSTN expression correlated with tumor microenvironment-related features, especially macrophages and cancer-associated fibroblasts (CAFs), and aligned with immune-regulatory gene signatures.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},345558,1790178967,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nPan-cancer characterization of POSTN and its clinical and microenvironmental associations in ER + breast cancer  \nXiaoyi Zhai1,2, Buerlan Yeerkenbieke1,2, DilinaerYeerxiati1,2, Yi Chen1,2, Haiyue Zhang1,2, Zhongqi Diao1,2, Jiaxuan Wang1,2, Yun Zhang2,3􀀍 & Wenjia Guo1,2􀀍  \nPeriostin (POSTN) is implicated in the progression of multiple malignancies; however, its pan-cancer landscape and clinical relevance in estrogen receptor (ER)-positive breast cancer remain insufficiently characterized. This study aimed to clarify the clinical significance of POSTN via pan-cancer analyses and to further explore its association with ER+ breast cancer. Public resources including Tumor Immune Estimation Resource 2.0 (TIMER2.0), The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Gene Expression Omnibus (GEO) were integrated to investigate POSTN expression patterns and their associations with prognosis, genetic/epigenetic alterations, tumor microenvironment (TME) features, and drug-response indicators. In the ER+ breast cancer cohort (defined by clinical ER annotation; PAM50 was used for molecular subtype stratification), differential expression, immune infiltration, drug–gene association analyses, and in vitro functional assays were performed. POSTN showed diagnostic and prognostic relevance in multiple cancer types and was associated with clinicopathological stage and molecular subtypes. POSTN expression correlated with TME-related features, particularly macrophages and cancer-associated fibroblasts (CAFs), and with immune-regulatory gene signatures. Drug–gene association analyses suggested that POSTN expression was related to differential predicted sensitivity/resistance to several small-molecule agents. Silencing POSTN reduced the migratory and invasive capacity of ER+ breast cancer cells. POSTN may serve as a candidate diagnostic and prognostic biomarker across cancers. In ER+ breast cancer, its expression is closely linked to stromal and immune features, supporting POSTN as a candidate microenvironment-associated biomarker with potential translational relevance.  \nKeywords POSTN, Pan-cancer, Breast cancer, Estrogen receptor, Prognosis  \nCancer remains a major public-health and socioeconomic challenge worldwide1.After lung and colorectal cancer, breast cancer is among the most frequently diagnosed malignancies and remains a leading cause of cancer-related death in women2,3. In China, approximately 416,000 women were diagnosed with breast cancer and about 117,000 died from the disease in 20204. Among breast cancers, early-stage estrogen receptor (ER) -positive/human epidermal growth factor receptor 2 (HER2)-negative tumors account for nearly 70% of cases5. Beyond tumor-cell–intrinsic alterations, remodeling of the stromal extracellular matrix (ECM) and the associated tumor microenvironment is increasingly recognized as a key layer that shapes malignant progression and therapeutic responsiveness. Among ECM-associated “matricellular” proteins that integrate structural and signaling cues, Periostin (POSTN) is an extracellular matrix protein implicated in cancer development and progression. It is frequently enriched in activated or desmoplastic stroma and is often produced by cancerassociated fibroblasts (CAFs), where it can reinforce extracellular-matrix remodeling and activate integrinlinked signaling pathways relevant to tumor progression and treatment response6. Mechanistically, POSTN-rich stromal niches are also connected to immune regulation: POSTN can promote immunosuppressive myeloid programs, and POSTN deficiency has been shown to reduce programmed cell death protein 1 (PD-1)⁺ tumorassociated macrophage infiltration while improving anti–PD-1 efficacy, supporting a functional link between a  \n1Department of Cancer Research Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, China. 2Xinjiang Key Laboratory of ","cbCaiuKshADncAxx","https://ap.wps.com/l/cbCaiuKshADncAxx","pdf",4286416,18,"English","# Pan-cancer rationale and study objective\n## Data integration across public genomic resources\n## ER+ breast cancer cohort analyses and molecular stratification\n## Clinical relevance: prognosis and clinicopathological associations\n## Tumor microenvironment links and immune infiltration\n## Drug-response association analyses\n## Functional validation in ER+ breast cancer cells","[{\"question\":\"What was the main goal of the study on POSTN in ER+ breast cancer?\",\"answer\":\"To clarify POSTN’s clinical significance using pan-cancer analyses and to further investigate its association with ER+ breast cancer, including prognosis, tumor microenvironment features, and drug-response indicators.\"},{\"question\":\"Which public datasets were integrated to evaluate POSTN expression and associations?\",\"answer\":\"The study integrated TIMER2.0, TCGA, GTEx, and GEO to analyze POSTN expression patterns and their relationships with prognosis, molecular alterations, tumor microenvironment traits, and predicted drug response.\"},{\"question\":\"How did POSTN relate to the tumor microenvironment in ER+ breast cancer?\",\"answer\":\"POSTN expression correlated with tumor microenvironment-related features, especially macrophages and cancer-associated fibroblasts (CAFs), and aligned with immune-regulatory gene signatures.\"}]","Pan-cancer characterization of POSTN and its clinical and microenvironmental associations in ER + breast cancer | PDF",1790058083,45]