[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331854-105":59,"doc-detail-331854-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pan-cancer-analysis-reveals-potential-immunological-and-prognostic-roles-of-mettl7a-in-human-cancers","Pan-cancer analysis reveals potential immunological and prognostic roles of METTL7A in human cancers","","Pan-cancer analysis investigates Methyltransferase-like protein 7A (METTL7A), an m6A RNA methyltransferase implicated in cancer prognosis and drug resistance, where prior comprehensive evaluation is limited. Expression patterns, prognostic performance, microsatellite instability (MSI), tumor mutational burden (TMB), and immune infiltration are assessed using TCGA, with immunohistochemistry validation across six tumor types. METTL7A is decreased in 19 TCGA cancers, links to MSI and TMB in LUAD, and correlates with multiple invasive immune cell populations. Across cancers, METTL7A relates to immune-therapy genes and shows reduced protein levels in several additional malignancies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-analysis-reveals-potential-immunological-and-prognostic-roles-of-mettl7a-in-human-cancers/331854/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-reveals-potential-immunological-and-prognostic-roles-of-mettl7a-in-human-cancers/331854.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the study address about METTL7A in cancers?","Question",{"text":112,"@type":113},"A comprehensive analysis of METTL7A is lacking despite evidence linking it to cancer prognosis and drug resistance. The work evaluates its expression, prognostic value, MSI/TMB associations, and immune infiltration relationships across cancers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was METTL7A expression and relevance evaluated?",{"text":117,"@type":113},"The study analyzes METTL7A expression and its prognostic performance across TCGA, including correlations with MSI and TMB, and immune infiltration patterns. It also uses immunohistochemistry to detect METTL7A in six tumor types for biological validation.",{"name":119,"@type":110,"acceptedAnswer":120},"What associations did METTL7A show with immune features and biomarkers?",{"text":121,"@type":113},"In LUAD, METTL7A correlates with both TMB and MSI. METTL7A also shows increasing correlation with invasive immune cells and has tumor-specific negative associations with several immune cell categories, alongside similar correlation patterns with immune-therapy-related genes across cancers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331854,1790174461,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nPan‑cancer analysis reveals potential immunological and prognostic roles of METTL7Ain human cancers  \nBin Wang1,4, Jingjing Jiang2,4, Danju Luo3* & Xiong Wang1*  \nMethyltransferase‑like protein 7A (METTL7A) is an m6A RNA methyltransferase that has been linked to cancer prognosis and drug resistance. However, a comprehensive analysis of METTL7A is lacking. The expression of METTL7A, prognostic performance, correlation with microsatellite instability (MSI), tumor mutational burden (TMB), and immune infiltration was investigated in The Cancer Genome Atlas (TCGA). Immunohistochemistry staining was applied to detect METTL7A in 6 tumors. METTL7A was significantly decreased in 19 cancers inTCGA including LUAD. Alterations of METTL7A include amplification and mutation, and epigenetic alterations revealed increased promoter methylation may result in down‑regulation of METTL7A in LUAD. We also found that METTL7A was linked to bothTMB and MSI in LUAD. METTL7A was increasingly correlated with invasive immune cells, while being negatively associated with Macrophages M0, Mast cells activated, activated memory CD4 T cells, CD8 T cells, and follicular helper T cells in several tumors. Additionally, METTL7A showed similar correlation with immune therapy‑related genes across cancers. Our biological validation found that the protein levels of METTL7A were down‑regulated in breast cancer (BRCA), endometrioid cancer (UCEC), colon cancer (COAD), prostate cancer (PRAD), and kidney clear cell carcinoma (KIRC), as detected by immunohistochemistry staining. Overall, our work indicates that METTL7A may serve as promising diagnostic and prognostic indicator of LUAD, and our work sheds light on the potential immunological and prognostic roles of METTL7A in human cancers.  \nKeywords Pan-cancer, Bioinformatic analysis, METTL7A, Expression, Prognosis  \nAbbreviations  \nm6AMETTL7ATCGA  \nTMB  \nMSI  \nTPM  \nROC  \nAUC  \nBRCA  \nUCEC  \nOS  \nGSEA  \nGO  \nBP  \nKEGG  \nBLCA  \nN6-methyladenosine Methyltransferase-like protein 7A The cancer genome atlas  \nTumor mutational burden Microsatellite instability  \nTranscripts per kilobase million Receiver operating characteristic Area under curve  \nBreast invasive carcinoma  \nUterine corpus endometrial carcinoma Overall survival  \nGene set enrichment analysis  \nGene ontology  \nBiological process  \nKyoto encyclopedia gene and genome Bladder urothelial carcinoma  \n1Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 3Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 4These authors contributed equally: Bin Wang and Jingjing Jiang.* email: [395393924@qq.com](395393924@qq.com); [wangxiong@tjh.tjmu.edu.cn](wangxiong@tjh.tjmu.edu.cn)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \nCESC Cervical squamous cell carcinoma and endocervical adenocarcinoma  \nCHOL Cholangio carcinoma  \nCOAD Colon adenocarcinoma  \nESCA Esophageal carcinoma  \nHNSC Head and neck squamous cell carcinoma  \nKICH Kidney chromophobe  \nKIRC Kidney renal clear cell carcinoma  \nKIRP Kidney renal papillary cell carcinoma LIHC Liver hepatocellular carcinoma LUSC Lung squamous cell carcinoma  \nPRAD Prostate adenocarcinoma  \nREAD Rectum adenocarcinoma  \nSTAD Stomach adenocarcinoma  \nCancer remains the leading cause of death and a significant public health concern, posing a threat to both our health and financial liability, as well as our quality of life1. In China alone, it is estimated that in 2022, there would be 4,820,000 new cancer cases, and 3,210,000 cancer-related deaths, with lung cancer being the most frequent type of cancer2. Today, cancer treatment strategies","cbCaino5HVMofIMb","https://ap.wps.com/l/cbCaino5HVMofIMb","pdf",9202093,14,"English","# Background\n## Cancer burden and treatment variability\n## Rationale for pan-cancer bioinformatics\n# METTL7A and m6A biology\n## Overview of m6A modification\n## METTL7A roles across cancer types\n# Study aims and approach\n## TCGA-based expression and prognostic assessment\n## MSI, TMB, and immune infiltration analyses\n## Immunohistochemistry validation","[{\"question\":\"What problem does the study address about METTL7A in cancers?\",\"answer\":\"A comprehensive analysis of METTL7A is lacking despite evidence linking it to cancer prognosis and drug resistance. The work evaluates its expression, prognostic value, MSI/TMB associations, and immune infiltration relationships across cancers.\"},{\"question\":\"How was METTL7A expression and relevance evaluated?\",\"answer\":\"The study analyzes METTL7A expression and its prognostic performance across TCGA, including correlations with MSI and TMB, and immune infiltration patterns. It also uses immunohistochemistry to detect METTL7A in six tumor types for biological validation.\"},{\"question\":\"What associations did METTL7A show with immune features and biomarkers?\",\"answer\":\"In LUAD, METTL7A correlates with both TMB and MSI. METTL7A also shows increasing correlation with invasive immune cells and has tumor-specific negative associations with several immune cell categories, alongside similar correlation patterns with immune-therapy-related genes across cancers.\"}]","Pan-cancer analysis reveals potential immunological and prognostic roles of METTL7A in human cancers | PDF",1789995510,35]