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Higher TRAF2/3/4/7 expression generally corresponds to poorer outcomes and correlates with TME and immune-related dimensions.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/pan-cancer-analysis-of-the-traf-family-genes-research-open-access/333423/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-of-the-traf-family-genes-research-open-access/333423.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main focus of this pan-cancer study?","Question",{"text":63,"@type":64},"It investigates how the TRAF family genes relate to prognosis, tumor microenvironment (TME), immune response, and drug sensitivity across multiple cancer types.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were the TRAF gene expression and prognostic associations assessed?",{"text":68,"@type":64},"Using current public databases and bioinformatic analysis to evaluate expression levels and prognostic significance in a pan-cancer context.",{"name":70,"@type":61,"acceptedAnswer":71},"Which TRAF genes showed elevated expression and worse patient outcomes?",{"text":72,"@type":64},"TRAF2, TRAF3, TRAF4, and TRAF7 were elevated across various cancers, and patients with higher expression generally had a worse prognosis.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333423,1790798582,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Yao et al. European Journal  \nEuropean Journal of Medical Research (2024) 29:307  \n[https://doi.org/10.1186/s40001-024-01875-8](https://doi.org/10.1186/s40001-024-01875-8 of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-024-01875-8 of Medical Research)  \n RESEARCH Open Access  \nPan-cancer analysis oftheTRAF family genes and their correlation with prognosis, TME, immune and drug sensitivity  \nBin Yao1†, Weikang Hu2†, Yu Chen3†, Jing Li4, Kuirong Jiang2* and Jin Dou4,5*  \nAbstract  \nBackground Tumor necrosis factor receptor-associated factors family genes play a pivotal role in tumorigenesis and metastasis, functioning as adapters or E3 ubiquitin ligases across various signaling pathways. To date, limited research has explored the association between tumor necrosis factor receptor-associated factors family genes and the clinicopathological characteristics of tumors, immunity, and the tumor microenvironment (TME) . This comprehensive study investigates the relationship between tumor necrosis factor receptor-associated factors family and prognosis, TME, immune response, and drug sensitivity in a pan-cancer context.  \nMethods Utilizing current public databases, this study examines the expression levels and prognostic significance of tumor necrosis factor receptor-associated factors family genes in a pan-cancer context through bioinformatic analysis. In addition, it investigates the correlation between tumor necrosis factor receptor-associated factors expression and various factors, including the TME, immune subtypes, stemness scores, and drug sensitivity in pan-cancer. Results Elevated expression levels of tumor necrosis factor receptor-associated factor 2, 3, 4, and 7 were observed across various cancer types. Patients exhibiting high expression of these genes generally faced a worse prognosis. Furthermore, a significant correlation was noted between the expression of tumor necrosis factor receptor-associated factors family genes and multiple dimensions oftheTME, immune subtypes, and drug sensitivity.  \nKeywords Tumor necrosis factor receptor-associated factors (TRAFs), Pan-cancer analysis, Tumor microenvironment (TME), Immune, Cancer prognosis, Drug sensitivity  \n†Bin Yao, Weikang Hu, andYu Chen contributed equally to this work.  \n*Correspondence:  \nKuirong Jiang [jiangkuirong@njmu.edu.cn](jiangkuirong@njmu.edu.cn)[ ](jiangkuirong@njmu.edu.cn)Jin Dou  \n[dj_0421@163.com](dj_0421@163.com)  \n1 Changshu NO.2 People’s Hospital, Changshu, China  \n2 Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China  \n3 Huai’an Hospital Affiliated to Yangzhou University, Huai’an, China  \n4 The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, China  \n5 Medical College, Yangzhou University, Yangzhou, China  \nIntroduction  \nTumor necrosis factor receptor-associated factors (TRAFs) comprise a group of cytoplasmic adaptor proteins that play diverse roles in mammalian physiological processes [1]. To date, this family includes six classical members (TRAF1–6) and one atypical member (TRAF7)[2, 3]. Notably, the classical members are characterized by a conserved amino acid sequence known as the TRAF domain, located at the C-terminal end. This domain is crucial for their interaction with various receptors and signaling proteins, integral to the function of TRAF proteins [4]. Except for TRAF1, all members of the TRAF family exhibit E3 ubiquitin ligase activity, attributed toa homogeneous RING finger domain at the N-terminal,  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the arti","cbCaiptJIrBXXuPN","https://ap.wps.com/l/cbCaiptJIrBXXuPN","pdf",6118462,18,"English","# Abstract\n## Background\n## Methods\n## Results\n# Introduction","[{\"question\":\"What is the main focus of this pan-cancer study?\",\"answer\":\"It investigates how the TRAF family genes relate to prognosis, tumor microenvironment (TME), immune response, and drug sensitivity across multiple cancer types.\"},{\"question\":\"How were the TRAF gene expression and prognostic associations assessed?\",\"answer\":\"Using current public databases and bioinformatic analysis to evaluate expression levels and prognostic significance in a pan-cancer context.\"},{\"question\":\"Which TRAF genes showed elevated expression and worse patient outcomes?\",\"answer\":\"TRAF2, TRAF3, TRAF4, and TRAF7 were elevated across various cancers, and patients with higher expression generally had a worse prognosis.\"}]","Pan-cancer analysis of the TRAF family genes - research open access | PDF",1790002378,45]