[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331361-105":59,"doc-detail-331361-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","pan-cancer-analysis-of-the-prognostic-and-immunological-roles-of-shp-1ptpn6","Pan-cancer analysis of the prognostic and immunological roles of SHP-1/ptpn6","","Pan-cancer investigation of SHP-1/ptpn6 evaluates its prognostic and immunological functions across 33 tumor types. Differential ptpn6 expression is observed between tumors and adjacent normal tissues, with ptpn6 levels significantly correlated to patient outcomes. In most cancers, ptpn6 associates with immune infiltration, supported by ptpn6-related genes/proteins enrichment analysis. Genetic alterations occur broadly, while epigenetic changes show phosphorylation shifts in 6 tumors and methylation changes in 12. Hypomethylation in 11 tumors coincides with increased ptpn6 expression in 8, implying a mechanistic link to tumor immunity.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-analysis-of-the-prognostic-and-immunological-roles-of-shp-1ptpn6/331361/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-of-the-prognostic-and-immunological-roles-of-shp-1ptpn6/331361.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main goal of the pan-cancer study on SHP-1/ptpn6?","Question",{"text":113,"@type":114},"To examine the prognostic value and immune-regulatory roles of ptpn6 across 33 tumor types, focusing on functional heterogeneity and clinical significance.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were ptpn6 expression differences and prognostic associations determined?",{"text":118,"@type":114},"ptpn6 differential expression was identified between cancer and adjacent normal tissues, and its expression was significantly correlated with tumor patient prognosis.",{"name":120,"@type":111,"acceptedAnswer":121},"What evidence links ptpn6 to tumor immune infiltration?",{"text":122,"@type":114},"In most cancers, ptpn6 expression significantly correlated with immune infiltration, and this relationship was further supported by ptpn6-related genes/proteins enrichment analyses.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331361,1790142586,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nPan-cancer analysis of the prognostic and immunological roles of SHP-1/ptpn6  \nPing Cui1,2,6, Jie Lian1,2,6, Yang Liu2,4, Dongsheng Zhang1,2, Yao Lin1,2, Lili Lu1, Li Ye1,2, Hui Chen2,4, SanqiAn1,2􀀍, Jiegang Huang2,3,5􀀍 & Hao Liang1,2􀀍  \nSHP-1, a nonreceptor protein tyrosine phosphatase encoded by ptpn6, has been regarded as a regulatory protein of hematopoietic cell biology for years. However, there is now increasing evidence to support its role in tumors. Thus, the role of ptpn6 for prognosis and immune regulation across 33 tumors was investigated, aiming to explore its functional heterogeneity and clinical significance in pan-cancer. Differential expression of ptpn6 was found between cancer and adjacent normal tissues, and its expression was significantly correlated with the prognosis of tumor patients. In most cancers, ptpn6 expression was significantly associated with immune infiltration. This was further confirmed by ptpn6-related genes/proteins enrichment analysis. Additionally, genetic alterations in ptpn6 was observed in most cancers. As for epigenetic changes, it’s phosphorylation levels significantly altered in 6 tumors, while methylation levels significantly altered in 12 tumors. Notably, the methylation levels of ptpn6 were significantly decreased in 11 tumors, accompanied by its increased expression in 8 of them, suggesting that the hypomethylation may be related to its increased expression. Our results show that ptpn6 plays a specific role in tumor immunity and exerts a pleiotropic effect in a variety of tumors. It can serve as a prognostic factor for some cancers. Especially in LGG, KIRC, UCS and TGCT, the increased expression of ptpn6 is associated with poor prognosis and high immune infiltration. This aids in understanding the role of ptpn6 in tumor biology, and can provide insight into presenting a potential biomarker for poor prognosis and immune infiltration in cancers.  \nKeywords ptpn6, Pan-cancer, Immune infiltration, Prognosis  \nCancer has been a leading cause of death and a significant obstacle affecting the quality of life for decades worldwide1. In recent years, advances in genomic methods have expanded our knowledge about gene expression, genetic, and epigenetic alterations at the pan-genomic level in various malignancies, thus accelerating the discovery of new tumor biomarkers and therapeutic targets2,3.  \nProtein phosphatases are key regulators that control the intracellular phosphorylation required for cellular homeostasis and have received great attention in recent years as the important potential therapeutic targets for cancers and other diseases4,5. Among those, the SH2 domain containing protein tyrosine phosphatase (PTP), SHP-1, is a cytosolic protein tyrosine phosphatase with 595-amino acid residue encoded by ptpn6, which has been shown to be involved in the regulation of hematopoietic cell biology6–9. Recently, accumulating evidence has suggested that SHP-1 also has an impact on the occurrence and development of tumors. Its coding gene, ptpn6, has been reported to be overexpressed in ovarian cancer and breast cancer in previous studies10–12. In contrast, its expression has been shown to be diminished or abolished in T-cell lymphomas, leukemias13–15, hepatocellular carcinoma (HCC)16 and some colorectal cancers17, 18. Furthermore, ptpn6 has also been proven to be associated with tumor microenvironment (TME)19–22, which plays critical roles in tumor development involving the interaction between cancer cells, tumor infiltrating immune cells, and their supporting cells. In addition, tumor therapeutic drugs targeting SHP-1( such as several SHP-1 inhibitors) have been developed,  \n1Life Science Institute, Guangxi Medical University, Nanning, China. 2Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, 22, Shuangyong Road, Nanning 530021, China. 3School of Public Health, Guangxi Medical U","cbCairrSSUBC4u5u","https://ap.wps.com/l/cbCairrSSUBC4u5u","pdf",3589748,17,"English","# Materials and methods\n## Differential expression analysis","[{\"question\":\"What was the main goal of the pan-cancer study on SHP-1/ptpn6?\",\"answer\":\"To examine the prognostic value and immune-regulatory roles of ptpn6 across 33 tumor types, focusing on functional heterogeneity and clinical significance.\"},{\"question\":\"How were ptpn6 expression differences and prognostic associations determined?\",\"answer\":\"ptpn6 differential expression was identified between cancer and adjacent normal tissues, and its expression was significantly correlated with tumor patient prognosis.\"},{\"question\":\"What evidence links ptpn6 to tumor immune infiltration?\",\"answer\":\"In most cancers, ptpn6 expression significantly correlated with immune infiltration, and this relationship was further supported by ptpn6-related genes/proteins enrichment analyses.\"}]","Pan-cancer analysis of the prognostic and immunological roles of SHP-1/ptpn6 | PDF",1789992917,43]