[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332909-105":59,"doc-detail-332909-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pan-cancer-analysis-of-the-potential-of-pea3-subfamily-genes-as-tumor-markers","Pan-cancer analysis of the potential of PEA3 subfamily genes as tumor markers","","Pan-cancer analysis evaluates Polyomavirus enhancer activator 3 (PEA3) subfamily ETS transcription factors (ETV1, ETV4, ETV5) as tumor biomarkers across diverse cancer types. Expression profiles and prognostic relevance are assessed using GEO, TCGA, and PrognoScan data combined with COX regression and Kaplan–Meier Plotter analyses. Associations are further examined between PEA3 subfamily expression and stemness scores, tumor microenvironment features, immune subtypes, and drug susceptibility. Results indicate elevated expression in cancers, coordinated biological functions, multiple cancer prognostic links, and correlations with stromal/immune scores and immune phenotypes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-analysis-of-the-potential-of-pea3-subfamily-genes-as-tumor-markers/332909/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-of-the-potential-of-pea3-subfamily-genes-as-tumor-markers/332909.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the goal of the pan-cancer analysis in this study?","Question",{"text":112,"@type":113},"To systematically evaluate how PEA3 subfamily genes relate to tumor development, prognosis, and the tumor microenvironment across different cancer types, and to test their utility as potential tumor markers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which datasets and methods are used to assess expression and prognosis?",{"text":117,"@type":113},"Expression profiles and prognostic significance are analyzed using GEO, TCGA, and PrognoScan, together with COX regression analyses and Kaplan–Meier Plotter.",{"name":119,"@type":110,"acceptedAnswer":120},"What key findings connect PEA3 subfamily genes to tumor biology and treatment response?",{"text":121,"@type":113},"ETV1, ETV4, and ETV5 show high expression in cancers and are linked to worse prognosis, stromal/immune tumor microenvironment scores, stemness scores, immune subtypes, and drug susceptibility patterns.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332909,1790950732,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nPan-cancer analysis of the potential of PEA3 subfamily genes as tumor markers  \nLingling Guan1,2, Runhao Zeng1, Yi Chen1, Guohua He1, Wenxia Yao1􀀍, Zhaoyu Liu1􀀍 & Hui Liu1,2􀀍  \nPolyomavirus enhancer activator 3 (PEA3), an ETS transcription factor, has been documented to regulate the development and metastasis of human cancers. Nonetheless, a thorough analysis examining the relationship between the PEA3 subfamily members and tumour development, prognosis, and the tumour microenvironment (TME) across various cancer types has not yet been conducted. The expression profiles and prognostic significance of the PEA3 subfamily were evaluated using data from the GEO, TCGA, and PrognoScan databases, in conjunction with COX regression analyses and the Kaplan–Meier Plotter. Furthermore, the relationships between PEA3 subfamily expression, stemness scores, tumor microenvironments, immune subtypes, and drug susceptibility across multiple cancer types were explored. We found that ETV1, ETV4 and ETV5 are highly expressed in cancer, and their biological functions are synergistic. In the prognostic analysis of the Cancer Genome Atlas, the PEA3 subfamily genes were found to be associated with the prognosis of multiple cancers such as Lung adenocarcinoma (LUAD), Liver hepatocellular carcinoma (LIHC), etc., and marked a worse prognosis at different endpoints. In addition, it was significantly correlated with the stromaland immune scores of pan-cancer, and also significantly associated with the RNA stemness score and DNA stemness score of pan-cancer. Expression levels of the PEA3 subfamily genes correlate with immune subtypes of LIHC, LUAD, and Lung squamous cell carcinoma. We also found a variety of drugs with positive and negative associations of ETV1, ETV4 and ETV5. These findings elucidate the role of the PEA3 subfamily gene as a biomarker for carcinogenesis and cancer progression, offering valuable insights for future research into the PEA3 subfamily gene as a potential therapeutic target across various cancer types.  \nKeywords The PEA3 subfamily, Tumor microenvironment , Pan-cancer  \nThe E26 transformation-specific (ETS) family encompasses a substantial group of 29 human transcription factors, all characterized by a highly conserved DNA-binding domain with a winged helix–turn–helix topology. These transcription factors specifically bind to 5′-GGA(A/T)−3′ motifs within DNA1. Numerous promoters harbor ETS/AP-1 composite binding sites that have the ability to modulate the sensitivity of promoters to the Ras/C-Raf/MEK/ERK1/2 signalling pathways in the presence of ETS-1 and other ETS proteins2. Furthermore, certain members of the ETS family have the potential to function as mediators within the MAPK/ERK signaling pathway, thereby modulating gene expression through phosphorylation mechanisms3–5. Notably, a specific MAPK phosphorylation site has been identified in close proximity to the pointed domain of ETS-25. These previous studies, with a solid experimental foundation, all point to the importance of ETS factors in the inflammatory environment milieu. It is imperative to investigate the correlation between members of the ETS transcription factor family and the manifestation of inflammatory phenotypes.  \nBased on their similarity, including high amino acid conservation in the ETS domain and subgroup-specific amino acid sequences, ETS transcription factors have been divided into 27 distinct subfamilies6. The PEA3 subfamily, which contains ETV1, ETV4 and ETV5 genes, promotes cell proliferation and differentiation, cancer cell migration and invasion and regulates apoptosis in breast cancer7, prostate cancer8and lymphoma9. The overexpression of ETV1, ETV4, and ETV5 is observed in numerous tumor types. Elevated levels of these transcription factors are frequently associated with a more aggressive tumor phenotype and increased drug  \n1Precision Medicine Center, The Fifth Aff","cbCaip5yg16uI2Re","https://ap.wps.com/l/cbCaip5yg16uI2Re","pdf",13923492,21,"English","# Pan-cancer evaluation of PEA3 subfamily genes\n## Prognostic value across multiple cancers\n## Links to tumor microenvironment and immune features\n## Associations with stemness and drug susceptibility","[{\"question\":\"What is the goal of the pan-cancer analysis in this study?\",\"answer\":\"To systematically evaluate how PEA3 subfamily genes relate to tumor development, prognosis, and the tumor microenvironment across different cancer types, and to test their utility as potential tumor markers.\"},{\"question\":\"Which datasets and methods are used to assess expression and prognosis?\",\"answer\":\"Expression profiles and prognostic significance are analyzed using GEO, TCGA, and PrognoScan, together with COX regression analyses and Kaplan–Meier Plotter.\"},{\"question\":\"What key findings connect PEA3 subfamily genes to tumor biology and treatment response?\",\"answer\":\"ETV1, ETV4, and ETV5 show high expression in cancers and are linked to worse prognosis, stromal/immune tumor microenvironment scores, stemness scores, immune subtypes, and drug susceptibility patterns.\"}]","Pan-cancer analysis of the potential of PEA3 subfamily genes as tumor markers | PDF",1789999958,53]