[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377448-105":59,"doc-detail-377448-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pan-cancer-analysis-of-the-cuproptosis-related-gene-dld","Pan-Cancer Analysis of the Cuproptosis-Related Gene DLD","","Pan-cancer analysis evaluates dihydrolipoamide dehydrogenase (DLD), a cuproptosis-associated cell-death gene whose precise function across tumors remains unclear. Expression, prognosis, and diagnostic performance of DLD were assessed using GTEx, TCGA, and multiple online datasets. Correlations were analyzed between DLD and immune microenvironment modulators, immune checkpoints, TMB, MSI, and drug sensitivity. DLD showed cancer-specific mRNA/protein differences and prognostic links in several cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-analysis-of-the-cuproptosis-related-gene-dld/377448/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-of-the-cuproptosis-related-gene-dld/377448.png","ImageObject",300,407,{"name":92,"@type":93},"Anna Hans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the focus of this pan-cancer study?","Question",{"text":112,"@type":113},"The study evaluates the expression, prognosis, and diagnostic value of the cuproptosis-related gene DLD across multiple cancers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which data sources are used to analyze DLD?",{"text":117,"@type":113},"The analysis uses GTEx, TCGA, and multiple online websites, including datasets accessed via the UNSC Xena platform and the Human Protein Atlas.",{"name":119,"@type":110,"acceptedAnswer":120},"How is DLD linked to clinical and immune features?",{"text":121,"@type":113},"DLD expression correlates with survival in multiple cancers and shows relationships with immune microenvironment modulators, immune checkpoints, TMB, and MSI, and with oncology drug sensitivity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377448,1790493050,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909892332657,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Hindawi  \nMediators ofInflammation  \nVolume 2023, Article ID 5533444, 15 pages [https://doi.org/10.1155/2023/5533444](https://doi.org/10.1155/2023/5533444)  \nResearch Article  \nPan-Cancer Analysis of the Cuproptosis-Related Gene DLD  \nJiahui Lin , 1 Guowei Wang ,2 Sha Cheng , 1 Yanan Hu ,2 Huan Li , 1  \nWanjiang Feng ,2 Xiaoming Liu , 1 and Canxia Xu 1  \n1Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha 410013, China 2Center for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China  \nCorrespondence should be addressed to Canxia Xu; [xucanxia2000@163.com](xucanxia2000@163.com)  \nReceived 12 July 2023; Revised 1 November 2023; Accepted 6 November 2023; Published 30 November 2023  \nAcademic Editor: Antonella Fioravanti  \nCopyright © 2023 Jiahui Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nBackground. Cancer affects millions of people each year and imposes a huge economic and social burden worldwide. Cuproptosis is a recently discovered novel mode of cell death. The exact function of the cuproptosis-related gene dihydrolipoamide dehydrogenase (DLD) and its role in pan-cancer is unknown. Methods. Data were retrieved from the GTEx, TCGA, and multiple online websites. These data were used to assess the expression, prognosis, and diagnostic value of DLD in various tumors. The relationship of DLD with immune microenvironment immunomodulators, immune checkpoints, tumor mutational load (TMB), microsatellite instability (MSI), and oncology drug sensitivity was explored by correlation analysis. Results. The mRNA and protein expression of DLD differs in most cancers. Survival analysis showed that DLD was associated with prognosis with KIRC, KIRP, KICH, and UCS. DLD had a strong diagnostic value in KIRC, GBM, PAAD, and LGG (AUC > 0.9) . DLD promoter methylation affects the aberrant expression of LIHC, LUSC, PAAD, READ, and THCA. DLD was negatively correlated with stromal score, immune score, and ESTIMATE score in UCEC, TGCT, LUSC, and SARC. In UCS, resting memory CD4 T cells and activated NK cells were significantly correlated with DLD expression. Significant correlations were also observed between DLD expression and immunomodulators, immune checkpoints, TMB, and MSI in various cancers. Importantly, we also identified a number of potential drugs that may target DLD. Conclusion. DLD expression is associated with a variety of tumor prognoses and plays an integral role in tumorigenesis, tumor metabolism, and immunity.  \n1. Introduction  \nDespite available surgical and chemotherapy treatments, cancer mortality remains high [1] . Cancer is driven by genetic changes and is a multifactorial, multistep, complex process [2, 3] . Meanwhile, metabolism is important in the carcinogenesis process, and in recent years, metabolismtargeted therapy has become an important part of tumor treatment [4, 5] . Tumorigenesis is complex; therefore, it is important to perform pan-cancer expression analysis of genes of interest and to assess their relevance to clinical prognosis and underlying molecular mechanisms.  \nDLD, also known as dihydrolipoamide dehydrogenase, is a component of the glycine cleavage system and an E3 component of the three alpha-keto acid dehydrogenase complexes [6, 7] . DLD is mainly localized in the mitochondria and, to a lesser extent, in the nucleus [8] . DLD variants are involved in multiple diseases [9, 10] . DLD deficiency is an  \nautosomal recessive metabolic disorder [11, 12] . Clinically, affected individuals develop lactic acidosis and deterioration of neurological function due to the sensitivity of the central nervous system to defects in oxidative metabolism [13–15] . The DLD gene is a recently identified important gene associated with cuproptosis and regulates a specific ","cbCainQTr0a7p6X9","https://ap.wps.com/l/cbCainQTr0a7p6X9","pdf",5274391,15,"English","# Background\n# Introduction\n# Materials and Methods\n## Data Download and Analysis","[{\"question\":\"What is the focus of this pan-cancer study?\",\"answer\":\"The study evaluates the expression, prognosis, and diagnostic value of the cuproptosis-related gene DLD across multiple cancers.\"},{\"question\":\"Which data sources are used to analyze DLD?\",\"answer\":\"The analysis uses GTEx, TCGA, and multiple online websites, including datasets accessed via the UNSC Xena platform and the Human Protein Atlas.\"},{\"question\":\"How is DLD linked to clinical and immune features?\",\"answer\":\"DLD expression correlates with survival in multiple cancers and shows relationships with immune microenvironment modulators, immune checkpoints, TMB, and MSI, and with oncology drug sensitivity.\"}]","Pan-Cancer Analysis of the Cuproptosis-Related Gene DLD | PDF",1790225000,38]