[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333606-105":59,"doc-detail-333606-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pan-cancer-analysis-of-serpine1-with-a-concentration-on-immune-therapeutic-and-prognostic-in-gastric-cancer","Pan-cancer analysis of SERPINE1 with a concentration on immune therapeutic and prognostic in gastric cancer","","The serine protease inhibitor clade E member 1 (SERPINE1) regulates the plasminogen/plasminase system and has been linked to tumor progression and metastasis across cancers. Pan-cancer analyses of SERPINE1’s predictive value and immune-related responses have remained limited. This study assessed differential expression, survival outcomes, and associations with microsatellite instability and immune infiltration using public cohorts and pathway enrichment, and validated gastric cancer effects in vitro.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-analysis-of-serpine1-with-a-concentration-on-immune-therapeutic-and-prognostic-in-gastric-cancer/333606/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-of-serpine1-with-a-concentration-on-immune-therapeutic-and-prognostic-in-gastric-cancer/333606.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of the study on SERPINE1?","Question",{"text":112,"@type":113},"To evaluate SERPINE1’s pan-cancer expression patterns, prognostic significance, and immune-related role, with emphasis on gastric cancer. It also examines links to clinical and molecular features and tests functional effects in vitro.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which publicly available resources were used to analyze SERPINE1?",{"text":117,"@type":113},"The study uses data from The Cancer Genome Atlas and Genotype-Tissue Expression databases, along with Kaplan–Meier plotter and survival data analysis. It further applies enrichment analysis and Gene Set Enrichment Analysis for pathway insights.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the relationship between SERPINE1 and immune infiltration assessed?",{"text":121,"@type":113},"The study analyzed correlations between SERPINE1 expression and immune infiltration in gastric cancer using online data. It reports that higher SERPINE1 expression aligns with increased immune cell infiltration.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333606,1791048389,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","DOI: 10. 1111/jcmm.18579  \nOR I G I NAL ART I C L E  \nPan-cancer analysis of SERPINE1 with a concentration on immune therapeutic and prognostic in gastric cancer  \nYuming Ju | Zeshen Wang | Qiancheng Wang | Shiyang Jin | Pengcheng Sun | Yuzhe Wei | Guanyu Zhu | Kuan Wang  \nDepartment of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, China  \nCorrespondence  \nKuan Wang, Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, China. [Email:](Email: 0696@hrbmu.edu.cn)[ 0696@hrbmu.edu.cn](Email: 0696@hrbmu.edu.cn)  \nAbstract  \nThe serine protease inhibitor clade E member 1 (SERPINE1) is a key modulator of the plasminogen/plasminase system and has been demonstrated to promote tumor progression and metastasis in various tumours. However, although much literature has explored the cancer-promoting mechanism of SERPINE1, the pan-cancer analyses of its predictive value and immune response remain unexplored. The differential expression, and survival analysis of SERPINE1 expression in multiple cancers were analysed using The Cancer Genome Atlas and Genotype-Tissue Expression database. Kaplan– Meier (K–M) plotter and survival data analysis were used to analyze the prognostic value of SERPINE1 expression, including overall survival (OS), disease-specific survival, disease-free interval and progression-free interval and investigated the relationship of SERPINE1 expression with microsatellite instability. We further analysed the correlation between the expression of SERPINE1 and immune infiltration. The Kyoto Encyclopaedia of Genes and Genomes pathway was used for enrichment analysis, and the Gene Set Enrichment Analysis (GSEA) database was used to perform pathway analysis. Finally, in vitro experiments demonstrated that knockdown or overexpression of SERPINE1 could alter the proliferation and migration of gastric cancer (GC) cells. The results indicated that SERPINE1 expression levels different significantly between cancer and normal tissues, meanwhile, it was highly expressed in various cancers. By analysing online data, it has been observed that the gene SERPINE1 exhibits heightened expression levels across a variety of human cancers, significantly impacting patient survival rates. Notably, the presence of SERPINE1 was strongly associated with decrease OS and disease-free survival in individuals diagnosed with GC. Furthermore, an observed link indicates that higher levels of SERPINE expression are associated with increased infiltration of immune cells in GC. Finally, in vitro experiments showed that knockdown or overexpression of SERPINE1 inhibited the growth, and migration, of GC cells. SERPINE1expression potentially represents a novel prognostic biomarker due to its significant association with immune cell infiltration in GC. This study shows that SERPINE1 is an oncogene that participates in regulating the immune infiltration and affecting the prognosis of patients in multiple cancers, especially  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s) . Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.  \nJ Cell Mol Med. 2024;28:e18579 .  \n[https://doi.org/10.1111/jcmm.18579](https://doi.org/10.1111/jcmm.18579)  \n[wileyonlinelibrary.com/journal/jcmm](wileyonlinelibrary.com/journal/jcmm)  \n1 of 13  \nin GC. These findings underscore the importance of further investigating the role of SERPINE1 in cancer progression and offer a promising direction for the development of new therapeutic strategies.  \nK E Y WO R D S  \nbioinformatics, immune infiltrating, pan-cancer analysis, SERPINE1  \n1 | INTRODUCTION  \nCancer represents a significant public health challenge globally and stands as the leading cause of mortality in the world.1 Despite ","cbCaijE0OaLUC9C4","https://ap.wps.com/l/cbCaijE0OaLUC9C4","pdf",17824752,13,"English","# Abstract\n# Introduction\n## Background and clinical challenge\n## Immunotherapy and biomarker need\n## SERPINE1 biological function\n## Study aims and analysis strategy","[{\"question\":\"What is the main purpose of the study on SERPINE1?\",\"answer\":\"To evaluate SERPINE1’s pan-cancer expression patterns, prognostic significance, and immune-related role, with emphasis on gastric cancer. It also examines links to clinical and molecular features and tests functional effects in vitro.\"},{\"question\":\"Which publicly available resources were used to analyze SERPINE1?\",\"answer\":\"The study uses data from The Cancer Genome Atlas and Genotype-Tissue Expression databases, along with Kaplan–Meier plotter and survival data analysis. It further applies enrichment analysis and Gene Set Enrichment Analysis for pathway insights.\"},{\"question\":\"How was the relationship between SERPINE1 and immune infiltration assessed?\",\"answer\":\"The study analyzed correlations between SERPINE1 expression and immune infiltration in gastric cancer using online data. It reports that higher SERPINE1 expression aligns with increased immune cell infiltration.\"}]","Pan-cancer analysis of SERPINE1 with a concentration on immune therapeutic and prognostic in gastric cancer | PDF",1790003211,33]