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",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/pan-cancer-analysis-of-rna-5-methylcytosine-reader-alyref/333163/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-of-rna-5-methylcytosine-reader-alyref/333163.png","ImageObject",300,407,{"name":42,"@type":43},"Patrick","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main focus of the study regarding ALYREF?","Question",{"text":63,"@type":64},"The study investigates the immuno-oncological impact of ALYREF in human cancer using pan-cancer analysis to define its role and relevance across cancer types.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How does ALYREF expression differ between tumor and normal samples?",{"text":68,"@type":64},"ALYREF shows differential expression between tumor and normal samples, and this change is strongly associated with patient prognosis in several cancers.",{"name":70,"@type":61,"acceptedAnswer":71},"Which cancer types and immune-infiltration patterns are highlighted in the ALYREF analysis?",{"text":72,"@type":64},"The results emphasize strong prognostic relevance in KIRP and LIHC, with ALYREF negatively correlated with most tumor-infiltrating cells in LUSC and DLBC, and positively correlated in LIHC, KICH, MESO, KIRP, and other cancers listed.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333163,1790013078,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","ONCOLOGY RESEARCH 2024 32(3): 503-515  \nPan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)  \nXING YE 1,\\#; ZHOUTING TUO2,\\#; KAI CHEN3; RUICHENG WU3; JIE WANG3; QINGXIN YU4; LUXIA YE5; AKIRA MIYAMOTO6; KOO HAN YOO7; CHI ZHANG8; WURAN WEI3; DENGXIONG LI3,*; DECHAO FENG3,*  \n1 Samuel Oschin Comprehensive Cancer Institute, Department of Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA  \n2 Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China  \n3 Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China  \n4 Department of Pathology, Ningbo Diagnostic Pathology Center, Ningbo, 315021, China  \n5 Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, China  \n6 Department of Rehabilitation, West Kyushu University, Kanzaki-shi, 842-8585, Japan  \n7 Department of Urology, Kyung Hee University, Seoul, 446 701, South Korea  \n8 Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China  \nKey words: Pan-cancer, RNA 5-methylcytosine, ALYREF, Immuno-oncological effects  \nAbstract: The increasing interest in RNA modifications has significantly advanced epigenomic and epitranscriptomic technologies. This study focuses on the immuno-oncological impact of ALYREF in human cancer through a pancancer analysis, enhancing understanding of this gene’s role in cancer. We observed differential ALYREF expression between tumor and normal samples, correlating strongly with prognosis in various cancers, particularly kidney renal papillary cell carcinoma (KIRP) and liver hepatocellular carcinoma (LIHC) . ALYREF showed a negative correlation with most tumor-infiltrating cells in lung squamous cell carcinoma (LUSC) and lymphoid neoplasm diffuse large Bcell lymphoma (DLBC), while positive correlations were noted in LIHC, kidney chromophobe (KICH), mesothelioma (MESO), KIRP, pheochromocytoma and paraganglioma (PARD), and glioma (GBMLGG) . Additionally, ALYREF expression was closely associated with tumor heterogeneity, stemness indices, and a high mutation rate in TP53 across these cancers. In conclusion, ALYREF may serve as an oncogenic biomarker in numerous cancers, meriting  \nfurther research attention.  \nIntroduction  \nThe core tenet of the central dogma in molecular biology, a landmark achievement of the 20th century, posits that genetic information can be exchanged between nucleic acids and proteins, two distinct classes of biological macromolecules [1] . This concept encompasses transcription and translation processes, where genetic information transfers from DNA to RNA and from RNA to proteins, and includes DNA replication. Additionally, RNA self-replication in some viruses (e.g., Tobacco Mosaic Virus) and reverse transcription of RNA into DNA in others (like  \n*Address correspondence to: Dechao Feng, [fdcfenix@stu.scu.edu.cn](fdcfenix@stu.scu.edu.cn); [dechaofeng66@swmu.edu.cn](dechaofeng66@swmu.edu.cn); Dengxiong Li, [lidengxiongwch@stu.scu.edu.cn](lidengxiongwch@stu.scu.edu.cn)  \n\\#These authors contributed equally to this work Received: 16 August 2023; Accepted: 01 December 2023; Published: 06 February 2024  \ncertain oncogenic viruses) complement this rule [1–3] . In these processes, epigenomics plays a pivotal role in various cellular physiology processes in eukaryotes. It involves abiodiverse assembly of covalent modifications to histone proteins and nucleic acids, changing nucleosomes’spatiotemporal arrangement, regulating chromatin’s threedimensional conformation and nuclear topology, RNA splicing mechanisms, RNA binding protein location and activity, and transcribed elements of the non-protein coding genome. These elements work in concert to dynamically regulate chromatin structure and fine-tune gene expression, influencing biological properties [4] . Consequently, epig","cbCaie0vDst8nrfj","https://ap.wps.com/l/cbCaie0vDst8nrfj","pdf",27830795,13,"English","# Abstract\n## Differential expression and prognosis associations\n## Immune infiltration correlations\n## Links to heterogeneity, stemness, and TP53 mutation rate\n## Conclusion and biomarker implications","[{\"question\":\"What is the main focus of the study regarding ALYREF?\",\"answer\":\"The study investigates the immuno-oncological impact of ALYREF in human cancer using pan-cancer analysis to define its role and relevance across cancer types.\"},{\"question\":\"How does ALYREF expression differ between tumor and normal samples?\",\"answer\":\"ALYREF shows differential expression between tumor and normal samples, and this change is strongly associated with patient prognosis in several cancers.\"},{\"question\":\"Which cancer types and immune-infiltration patterns are highlighted in the ALYREF analysis?\",\"answer\":\"The results emphasize strong prognostic relevance in KIRP and LIHC, with ALYREF negatively correlated with most tumor-infiltrating cells in LUSC and DLBC, and positively correlated in LIHC, KICH, MESO, KIRP, and other cancers listed.\"}]","Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF) | PDF",1790001216,33]