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Methods: Analyze differential CCNE1 expression in multiple tumors using TIMER and GEPIA; evaluate prognosis via GEPIA and Kaplan–Meier Plotter; assess immune infiltration with TIMER and immune-related context via cBioPortal mutation data. Results: CCNE1 is highly expressed across numerous tumor types, with high expression linked to poorer overall survival in several cancers and correlated with immune infiltration in specific cohorts. Conclusions: CCNE1 is proposed as a potential biomarker for tumor prognosis and immune infiltration.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-analysis-identifies-the-oncogenic-role-of-ccne1-in-human-cancers/332942/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-identifies-the-oncogenic-role-of-ccne1-in-human-cancers/332942.png","ImageObject",300,407,{"name":92,"@type":93},"Theodora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-14","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study objective regarding CCNE1?","Question",{"text":112,"@type":113},"The study examines CCNE1 expression patterns across cancers and evaluates its prognostic relevance and association with immune cell infiltration.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which databases are used to assess CCNE1 expression and prognosis?",{"text":117,"@type":113},"TIMER and GEPIA are used for differential expression across tumors, while GEPIA and Kaplan–Meier Plotter are used to evaluate prognostic significance.",{"name":119,"@type":110,"acceptedAnswer":120},"What overall conclusion is drawn from the results?",{"text":121,"@type":113},"CCNE1 is expected to be a potential biomarker for tumor prognosis and immune infiltration across multiple cancer types.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332942,1790179425,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","[www.aging-us.com](www.aging-us.com) AGING 2024, Vol. 16, No. 21  \nResearch Paper  \nPan-cancer analysis identifies the oncogenic role of CCNE1 in human cancers  \nYujie Ouyang1,*, Ziyi Wu2,*, Dilihumaer Aili3, Chunhua Yang4, Hui Zhang5, Tong Wu4  \n1 Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China  \n2 Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China  \n3 Department of Orthopedic Surgery, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Ürümqi 830054, China  \n4 Department of Orthopedics, Changsha Hospital, Xiangya Medical College, Central South University, Changsha 410005, China  \n5 Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China  \n*Co-first authors  \nCorrespondence to: Hui Zhang, Tong Wu; email: [zhanghui3463@csu.edu.cn](zhanghui3463@csu.edu.cn); [tong_wu0727@163.com](tong_wu0727@163.com), [https://orcid.org/0009-0009-9647-0763](https://orcid.org/0009-0009-9647-0763)  \nKeywords: CCNE1, pan-cancer, prognosis, immune infiltration  \nReceived: March 9, 2024 Accepted: November 11, 2024 Published: November 25, 2024  \nCopyright: © 2024 Ouyang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nObjective: To investigate expression, prognosis, immune cell infiltration of Cyclin E1 (CCNE1) in cancer.  \nMethods: We used TIMER and GEPIA datasets to analyze the differential expression of CCNE1 in multiple tumors. GEPIA and Kaplan-Meier plotter databases were utilized to observe the prognostic significance of CCNE1 in cancer. TIMER and cBioPortal databases were adopted for the analysis regarding immune infiltration and mutation respectively.  \nResults: The results showed that CCNE1 was highly expressed in multiple cancers including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, READ, STAD, THCA, UCEC (P \u003C 0.001) and CESC (P \u003C 0.01) . High CCNE1 expression was associated with a poor overall survival prognosis in several cancers, including ACC, BRCA, KIRC, KIRP, LGG, LIHC, LUAD and MESO. Additionally, CCNE1 expression was correlated with the cancer-associated immune infiltration level in BRCA, COAD, LUSC, STAD and THYM.  \nConclusions: CCNE1 is expected to be a potential biomarker for tumor prognosis and immune infiltration in various cancers.  \nINTRODUCTION  \nThe mechanism of tumorigenesis is complex, and the same gene has different mechanisms of action indifferent tumors [1, 2] . Pan-cancer expression analysis can effectively evaluate the mechanism of action of the same gene in different tumors, the predictive value of prognosis and survival of cancer patients and the effect  \nof gene action from the molecular mechanism. Meanwhile, it can better help researchers in different specialties to clarify the overall role of genes in tumorigenesis. GEO and TCGA databases have a large number of functional genome data settings, and mainly focus on the role of these genes in different tumors, which is helpful for our relevant pan-cancer analysis [3–5] .  \n13392  \nOne of the primary goals of cancer research is not only to understand tumor biology but also to improve patient outcomes through therapeutic interventions. Immunotherapies, including neoadjuvant and adjuvant treatments, represent a significant advancement in cancer therapy [6, 7] . However, the efficacy of these treatments often depends on the specific molecular and genetic landscape of the tumor. Understanding the expression of key genes, such as those involved in immune response or cell cycle regulation, across different cancers could help identify patients who would benefit most from immunotherapy. Pan-cancer analysis, by revealing g","cbCaicbSTP4sqTns","https://ap.wps.com/l/cbCaicbSTP4sqTns","pdf",3005674,17,"English","# Abstract\n# Introduction\n# Materials and Methods\n## Expression of CCNE1 in pan-cancer\n## Immune infiltration and genetic mutation analysis","[{\"question\":\"What is the study objective regarding CCNE1?\",\"answer\":\"The study examines CCNE1 expression patterns across cancers and evaluates its prognostic relevance and association with immune cell infiltration.\"},{\"question\":\"Which databases are used to assess CCNE1 expression and prognosis?\",\"answer\":\"TIMER and GEPIA are used for differential expression across tumors, while GEPIA and Kaplan–Meier Plotter are used to evaluate prognostic significance.\"},{\"question\":\"What overall conclusion is drawn from the results?\",\"answer\":\"CCNE1 is expected to be a potential biomarker for tumor prognosis and immune infiltration across multiple cancer types.\"}]","Pan-cancer analysis identifies the oncogenic role of CCNE1 in human cancers | PDF",1790000076,43]