[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332220-105":59,"doc-detail-332220-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pan-cancer-analysis-and-the-oncogenic-role-of-glypican-1-in-hepatocellular-carcinoma","Pan-cancer analysis - and the oncogenic role of Glypican 1 in hepatocellular carcinoma","","Glypican 1 (GPC-1) is frequently aberrantly expressed in multiple cancers, yet its role in hepatocellular carcinoma (HCC) remains insufficiently characterized. Using raw data from TCGA, GTEx, and TIMER, the study maps the GPC-1 expression landscape across pan-cancer contexts and investigates GPC-1 function in liver cancer cells. Results show elevated GPC-1 in HCC, inverse association with survival, and positive links with immune infiltration and clinical stage. Functional assays indicate GPC-1 promotes proliferation and suppresses apoptosis. WGCNA and HCCDB highlight Akt as a key mediator through the AKT signaling pathway, supporting GPC-1 as a therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pan-cancer-analysis-and-the-oncogenic-role-of-glypican-1-in-hepatocellular-carcinoma/332220/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pan-cancer-analysis-and-the-oncogenic-role-of-glypican-1-in-hepatocellular-carcinoma/332220.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was GPC-1 expression analyzed across cancers in this study?","Question",{"text":112,"@type":113},"The study used raw datasets from TCGA, GTEx, and TIMER to comprehensively analyze GPC-1 expression patterns in pan-cancer contexts.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the relationship between GPC-1 and patient outcomes in hepatocellular carcinoma?",{"text":117,"@type":113},"GPC-1 expression in HCC is highly elevated and negatively correlated with survival, indicating an unfavorable prognostic association.",{"name":119,"@type":110,"acceptedAnswer":120},"Which pathway is implicated in the oncogenic effects of GPC-1 in HCC?",{"text":121,"@type":113},"WGCNA and HCCDB analyses point to Akt as a key molecule, suggesting that GPC-1 regulates malignant behaviors via the AKT signaling pathway.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332220,1790216913,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nPan‑cancer analysis  \nand the oncogenic role of Glypican 1 in hepatocellular carcinoma  \nLi Cao2,6, Fang Li2,6, Shuang Cai2, Jinyuan Zhang2, Chen Guo2, Sadiq Ali2, Jing Zhou2, Xintao Jing2, Xiaofei Wang3*, Yannan Qin2,4* & Fei Wu1,2,5*  \nRecent studies indicate that Glypican 1 (GPC‑1) is aberrantly expressed and plays a key role in certain cancers, but little is known in the hepatocellular carcinoma. Raw data from TCGA, GTEx and TIMER databases were utilized to comprehensively analyze GPC‑1 expression landscape in pan‑cancer, and the biological function of GPC‑1 was investigated in liver cancer cells. The results revealed that GPC‑1 is highly expressed in HCC, negatively correlated with survival, and also positively correlated with immune infiltration and clinical stage. Furthermore, GPC‑1 promoted cell proliferation and inhibited apoptosis inthe HCC cell lines. WGCNA analysis and HCCDB database revealed that Akt acted as a key molecule related to GPC‑1, influencing biological functions and regulating cell malignant behaviors via theAKT signaling pathway. In conclusion, our findings provide a relatively comprehensive understanding of the oncogenic role ofGPC‑1 in HCC, implying that GPC‑1 could serve as an innovative therapeutic target.  \nKeywords GPC-1, Pan-cancer analysis, HCC, Proliferation, Apoptosis  \nAbbreviations  \nGPCs Glypicans  \nWGCNA Weighted gene co-expression network analysis KEGG Kyoto Encyclopedia of Genes and Genomes GO Gene ontology  \nCC Cellular component  \nACC Adrenocortical carcinoma  \nBRCA Breast invasive carcinoma  \nCHOL Cholangiocarcinoma ESCA Esophageal carcinoma  \nHNSC Head and neck squamous cell carcinoma KIRC Kidney renal clear cell carcinoma  \nLAML Acute myeloid leukemia LIHC Liver hepatocellular carcinoma LUSC Lung squamous cell carcinoma  \nOV Ovarian serous cystadenocarcinoma PCPG Pheochromocytoma and Paraganglioma READ Rectum adenocarcinoma  \nSKCM Skin cutaneous melanoma  \nTGCT Testicular germ cell tumors THYM Thymoma  \nUCS Uterine carcinosarcoma  \n1Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710000, Shaanxi, People’s Republic of China. 2Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, Shaanxi, People’s Republic of China. 3Biomedical Experimental Center of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, People’s Republic of China. 4Institute of Genetics and Development Biology, Translational Medicine Institute, Xi’an Jiaotong University, Xi’an 710301, Shaanxi, People’s Republic of China. 5Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710000, Shaanxi, People’s Republic of China. 6These authors contributed equally: Li Cao and Fang Li. *email:  \n[wxiaofei@xjtu.edu.cn](wxiaofei@xjtu.edu.cn); [yannan159@xjtu.edu.cn](yannan159@xjtu.edu.cn); [wufei931105@xjtu.edu.cn](wufei931105@xjtu.edu.cn)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \nHS Heparan sulfate  \nTIMER Tumor immune estimation resource  \nOS Overall survival  \nBP Biological process  \nMF Molecular function  \nBLCA Bladder urothelial carcinoma  \nCESC Cervical and endocervical cancers  \nDLBC Lymphoid neoplasm diffuse large B-cell lymphoma GBM Glioblastoma multiforme  \nKICH Kidney chromophobe  \nKIRP Kidney renal papillary cell carcinoma LGG Brain lower grade glioma  \nLUAD Lung adenocarcinoma MESO Mesothelioma  \nPAAD Pancreatic adenocarcinoma  \nPRAD Prostate adenocarcinoma  \nSARC Sarcoma  \nSTAD Stomach adenocarcinoma  \nTHCA Thyroid carcinoma  \nUCES Uterine corpus endometrial carcinoma UVM Uveal melanoma  \nCancer is a major public health problem worldwide and is considered to be the leading cause of death worldwide, contributing to rapidly increasing global morbidity and mortality1. According to global cancer statistics, there were 19,292,789 new cancer cases and 9,958,133 de","cbCaiqKMUnCb9Xg4","https://ap.wps.com/l/cbCaiqKMUnCb9Xg4","pdf",14538856,18,"English","# Background and significance\n# Pan-cancer expression landscape of GPC-1\n# Clinical correlations in HCC\n# Cellular function: proliferation and apoptosis\n# Mechanistic insight: Akt and AKT signaling pathway\n# Conclusion and therapeutic implications","[{\"question\":\"How was GPC-1 expression analyzed across cancers in this study?\",\"answer\":\"The study used raw datasets from TCGA, GTEx, and TIMER to comprehensively analyze GPC-1 expression patterns in pan-cancer contexts.\"},{\"question\":\"What is the relationship between GPC-1 and patient outcomes in hepatocellular carcinoma?\",\"answer\":\"GPC-1 expression in HCC is highly elevated and negatively correlated with survival, indicating an unfavorable prognostic association.\"},{\"question\":\"Which pathway is implicated in the oncogenic effects of GPC-1 in HCC?\",\"answer\":\"WGCNA and HCCDB analyses point to Akt as a key molecule, suggesting that GPC-1 regulates malignant behaviors via the AKT signaling pathway.\"}]","Pan-cancer analysis - and the oncogenic role of Glypican 1 in hepatocellular carcinoma | PDF",1789997402,45]