[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-385382-105":3,"detail-sidebar-cat-0-en-105":73,"doc-detail-385382-en":122},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":66,"head_meta":68,"extra_data":70,"updated_unix":72},105,"en","oxidative-stress-and-autophagy-mediated-immune-patterns-and-tumor-microenvironment-infiltration-characterization-in-gastric-cancer-research-paper","Oxidative stress and autophagy-mediated immune patterns and tumor microenvironment infiltration characterization in gastric cancer - Research Paper","","This research addresses how oxidative stress and autophagy—linked through oxidative stress and autophagy-related genes (OARGs)—shape gastric cancer biology and clinical outcomes. The study analyzes 808 gastric cancer samples and profiles 17 OARGs to map prognosis-associated oxidative stress and autophagy modification patterns. Three distinct alteration patterns show distinct immune-cell infiltration features. An OARGscore is derived via principal component analysis, with significant negative associations to immune cells, and high OARGscore predicts improved survival, higher mutation incidence, and better immunotherapy response. Candidate chemotherapeutic drugs are also suggested using oncoPredict.",{"@graph":14,"@context":65},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/oxidative-stress-and-autophagy-mediated-immune-patterns-and-tumor-microenvironment-infiltration-characterization-in-gastric-cancer-research-paper/385382/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/oxidative-stress-and-autophagy-mediated-immune-patterns-and-tumor-microenvironment-infiltration-characterization-in-gastric-cancer-research-paper/385382.png","ImageObject",300,407,{"name":42,"@type":43},"Anna Hans","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59],{"name":60,"@type":61,"acceptedAnswer":62},"How did the researchers estimate which drugs might work better for different patients?","Question",{"text":63,"@type":64},"They used the oncoPredict program to predict candidate chemotherapeutic drugs, showing differential predicted benefits between low-OARGscore and high-OARGscore patient groups.","Answer","https://schema.org",{"og:url":32,"og:type":67,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":69,"canonical":32},"index,follow",{"doc_id":71,"site_id":7},385382,1790811650,{"code":4,"msg":74,"data":75},"success",[76,80,84,88,93,98,101,106,111,114,118],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":77,"show_sort_weight":78,"slug":79},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":81,"show_sort_weight":82,"slug":83},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Exam",70,"exam",{"id":89,"doc_module":4,"doc_module_name":25,"category_name":90,"show_sort_weight":91,"slug":92},5,"Comic",60,"comic",{"id":94,"doc_module":4,"doc_module_name":25,"category_name":95,"show_sort_weight":96,"slug":97},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":99,"slug":100},40,"healthcare",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},8,"Research & Report",30,"research-report",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},9,"Religion & Spirituality",20,"religion-spirituality",{"id":109,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":109,"slug":113},"World Cup","world-cup",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":115,"slug":117},10,"Lifestyle","lifestyle",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":89,"slug":121},19,"General","general",{"code":4,"msg":74,"data":123},{"doc_id":71,"user_id":124,"nickname":42,"user_avatar":125,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":131,"language":132,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":12,"update_tm":136,"read_time":91},5909892332657,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","[www.aging-us.com](www.aging-us.com) AGING 2023, Vol. 15, No. 21  \nResearch Paper  \nOxidative stress and autophagy-mediated immune patterns and tumor microenvironment infiltration characterization in gastric cancer  \nJifeng Liu1,*, Biao Zhang1,*, Yunshu Zhang1,*, Huahui Zhao1, Xu Chen1, Lei Zhong1, Dong Shang1  \n1 Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China  \n*Equal contribution and share first authorship  \nCorrespondence to: Xu Chen, Lei Zhong, Dong Shang; email: [1169777928@qq.com](1169777928@qq.com), [zhongl0126@163.com](zhongl0126@163.com), [shangdong@dmu.edu.cn](shangdong@dmu.edu.cn)  \nKeywords: oxidative stress, autophagy, gastric cancer, molecular features, tumor microenvironment  \nReceived: April 6, 2023 Accepted: October 4, 2023 Published: November 9, 2023  \nCopyright: © 2023 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nRecent years have seen a sharp rise in the amount of research on the connection between oxidative stress, autophagy, and cancer cells. However, the significant functions of oxidative stress and autophagy-related genes (OARGs) in gastric cancer (GC) are yet to be investigated integrally. Therefore, it will be a new and promising concept to search for novel OARG-related biomarkers to predict the prognosis and treatment response of GC. First, we assessed changes in prognosis and tumor microenvironment (TME) characteristics across the various oxidative stress and autophagy-related modification patterns based on a detailed analysis of 17 OARGs with prognostic significance of 808 GC samples. We identified three distinct OARG alteration patterns which displayed unique biological characteristics and immune cell infiltration features. Using principal component analysis methods, the OARGscore was developed to evaluate the OARG modification patterns of certain tumors. The negative connection between OARGscore and immune cells was statistically significant. Increased survival, a higher incidence of mutations, and a better response to immunotherapy were all predicted to be related to patients’ high-OARGscore. In addition, the candidate chemotherapeutic drugs were predicted using the oncoPredict program. The low-OARGscore group was predicted to benefit more from Ribociclib, Alisertib, Niraparib, Epirubicin, Olaparib, and Axitinib, while patients in the high-OARGscore group were predicted to benefit more from Afatinib, Oxaliplatin, Paclitaxel, 5−Fluorouracil, Dabrafenib and Lapatinib. Our findings offera specific method for predicting a patient’s prognosis and susceptibility to immunotherapy, as well as a promising insight of oxidative stress and autophagy in GC.  \nINTRODUCTION  \nAmong the most common forms of cancer, gastric cancer (GC) is a leading cause of cancer-related death worldwide, especially in East Asia [1, 2] . The pathological kind of more than 95% of cases of GC are of the stomach adenocarcinoma (STAD) [3] . The usual course  \nof action for GC is radical resection followed by adjuvant therapy. Despite accepting normal treatment, the 5-year survival rate is just 50%, and 70% of patients with GC experience recurrence or metastasis within 5 years [4] . Sadly, the needs for earlier diagnosis anda longer survival duration are not met now by GC diagnosis and treatment. Therefore, research into novel  \nbiomarkers with higher predictive values is urgently needed to enhance GC prognostication.  \nOxidative stress (OS) refers to the excessive accumulation of highly reactive molecules, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), in the body when subjected to various harmful stimuli, resulting in an imbalance of oxidative and antioxidant activity, leading to physiological and pathological responses from","cbCaidRYBpcigzVZ","https://ap.wps.com/l/cbCaidRYBpcigzVZ","pdf",5622358,24,"English","# Abstract\n## Study rationale and clinical need\n## Oxidative stress, autophagy, and OARG concept\n## Methods overview: patterns and OARGscore\n## Immune infiltration and immunotherapy predictions\n## Chemotherapy candidate prediction","[{\"question\":\"How did the researchers estimate which drugs might work better for different patients?\",\"answer\":\"They used the oncoPredict program to predict candidate chemotherapeutic drugs, showing differential predicted benefits between low-OARGscore and high-OARGscore patient groups.\"}]","Oxidative stress and autophagy-mediated immune patterns and tumor microenvironment infiltration characterization in gastric cancer - Research Paper | PDF",1790268347]