[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-374391-105":59,"doc-detail-374391-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","overview-of-oncology-drug-induced-cardiac-toxicity","Overview of Oncology - Drug-Induced Cardiac Toxicity","","Cancer medications can cause cardiac problems that are hard to manage in oncology patients due to the risk of complications and treatment interruptions. The term “drug induced cardiotoxicity” mainly reflects chemotherapy-related heart toxicity, including reduced left ventricular ejection fraction (LVEF) and possible progression to heart failure. Antracyclines, alkylating agents, and targeted therapies may produce harmful cardiac effects. Incidence varies with drug type, dose, duration, and baseline heart disease, while mechanisms involve complex pathways, including oxidative stress and reactive oxygen species-mediated cardiomyocyte injury and programmed cell death. Early detection and novel biomarkers, including genetic profiling, support personalized prevention and management to reduce cardiac events while preserving oncological efficacy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/overview-of-oncology-drug-induced-cardiac-toxicity/374391/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/overview-of-oncology-drug-induced-cardiac-toxicity/374391.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is drug-induced cardiotoxicity in oncology patients?","Question",{"text":113,"@type":114},"Drug-induced cardiotoxicity refers to heart toxicity caused by cancer therapies, most often chemotherapy, leading to reduced cardiac pumping efficiency and potentially heart failure.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which cancer treatments are highlighted as possible causes of cardiac harm?",{"text":118,"@type":114},"The article emphasizes anthracyclines, alkylating agents, and targeted therapies, including anti-HER2 receptor monoclonal antibody treatment.",{"name":120,"@type":111,"acceptedAnswer":121},"Why is early detection important in preventing cardiotoxicity?",{"text":122,"@type":114},"Early detection is critical because conventional biomarkers may only indicate damage already underway, while newer approaches aim to identify risk before clinical symptoms appear.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},374391,1790258815,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Review  \nOverview of Oncology: Drug-Induced Cardiac Toxicity  \nNilima Rajpal Kundnani 1,2, Vincenzo Passini 3, Iulia Stefania Carlogea 1, Patrick Dumitrescu 3, Vlad Meche 3, Roxana Buzas 4,5, * and Daniel Marius Duda-Seiman 1,2  \nAcademic Editor: Jimmy T. Efird  \nReceived: 6 February 2025  \nRevised: 9 April 2025  \nAccepted: 10 April 2025  \nPublished: 12 April 2025  \nCitation: Kundnani, N.R.; Passini, V.; Stefania Carlogea, I.; Dumitrescu, P.; Meche, V.; Buzas, R.; Duda-Seiman, D.M. Overview of Oncology:  \nDrug-Induced Cardiac Toxicity. Medicina 2025, 61, 709. [https://](https://)[ ](https://)[doi.org/10.3390/medicina61040709](doi.org/10.3390/medicina61040709)  \n[Copyright:](Copyright:) © 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 University Clinic of Internal Medicine and Ambulatory Care, Prevention and Cardiovascular Recovery, Department VI—Cardiology,“Victor Babes” University of Medicine and Pharmacy, 3000041 Timisoara, Romania; [knilima@umft.ro](knilima@umft.ro) (N.R.K.)  \n2 Research Centre of Timisoara Institute of Cardiovascular Diseases,“Victor Babes” University of Medicine and Pharmacy, 3000041 Timisoara, Romania  \n3 Faculty of Medicine,“Victor Babes” University of Medicine and Pharmacy, 3000041 Timisoara, Romania  \n4 1st Medical Semiology, Internal Medicine, Department V,“Victor Babes” University of Medicine and Pharmacy, 3000041 Timisoara, Romania  \n5 Center for Advanced Research in Cardiovascular Pathology and in Hemostaseology,“Victor Babes”  \nUniversity of Medicine and Pharmacy, 3000041 Timisoara, Romania  \n* [Correspondence: buzas.dana@umft.ro](Correspondence: buzas.dana@umft.ro)  \nAbstract: Cancer medications can cause cardiac issues, which are difficult to treat in oncologic patients because of the risk of complications. In some cases, this may significantly impact their well-being and treatment outcomes. Overall, these complications fall under the term “drug induced cardiotoxicity”, mainly due to chemotherapy drugs being specifically toxic to the heart, causing a decrease in the heart’s capacity to pump blood efficiently and leading to a reduction in the left ventricular ejection fraction (LVEF), and subsequently possibly leading to heart failure. Anthracyclines, alkylating agents, and targeted therapies for cancer hold the potential of causing harmful effects on the heart. The incidence of heartrelated issues varies from patient to patient and depends on multiple factors, including the type of medication, dosage, duration of the treatment, and pre-existing heart conditions. The underlying mechanism leading to oncologic-drug-induced cardiovascular harmful effects is quite complex. One particular group of drugs, called anthracyclines, have garnered attention due to their impact on oxidative stress and their ability to cause direct harm to heart muscle cells. Reactive oxygen species (ROS) cause harm by inducing damage and programmed cell death in heart cells. Conventional biomarkers alone can only indicate some degree of damage that has already occurred and, therefore, early detection is key. Novel methods like genetic profiling are being developed to detect individuals at risk, prior to the onset of clinical symptoms. Key management strategies—including early detection, personalized medicine approaches, and the use of novel biomarkers—play a crucial role in mitigating cardiotoxicity and improving patient outcomes. Identification of generated genetic alterations and the association to an increased likelihood of cardiotoxicity will allow treatment in a more personalized approach, aiming at decreasing rates of cardiac events while maintaining high oncological ","cbCaigJUhiTaj5Ii","https://ap.wps.com/l/cbCaigJUhiTaj5Ii","pdf",364457,21,"English","# Abstract\n# Keywords\n# Introduction\n## Importance of Recognizing Cardiotoxicity in Cancer Treatment","[{\"question\":\"What is drug-induced cardiotoxicity in oncology patients?\",\"answer\":\"Drug-induced cardiotoxicity refers to heart toxicity caused by cancer therapies, most often chemotherapy, leading to reduced cardiac pumping efficiency and potentially heart failure.\"},{\"question\":\"Which cancer treatments are highlighted as possible causes of cardiac harm?\",\"answer\":\"The article emphasizes anthracyclines, alkylating agents, and targeted therapies, including anti-HER2 receptor monoclonal antibody treatment.\"},{\"question\":\"Why is early detection important in preventing cardiotoxicity?\",\"answer\":\"Early detection is critical because conventional biomarkers may only indicate damage already underway, while newer approaches aim to identify risk before clinical symptoms appear.\"}]","Overview of Oncology - Drug-Induced Cardiac Toxicity | PDF",1790201571,53]