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This review examines randomized clinical trial evidence and evaluates molecular biology diagnostic approaches for accurate diagnosis and treatment. Liquid biopsy using cell-free DNA methylation profiling is assessed as a sensitive, non-invasive method for tumor origin identification, early screening, recurrence tracking, and prognostic evaluation. Challenges and guidance are emphasized.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ovarian-cancer-diagnosis-and-prognosis-based-on-cell-free-dna-methylation/330658/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ovarian-cancer-diagnosis-and-prognosis-based-on-cell-free-dna-methylation/330658.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is late detection common in ovarian cancer, and what impact does it have on survival?","Question",{"text":112,"@type":113},"Most ovarian cancer cases are diagnosed at a late stage due to the absence of effective diagnostic and monitoring markers, leading to low five-year survival. The text links late-stage detection to limited early indicators and overall poor outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does liquid biopsy play in diagnosing and monitoring ovarian cancer?",{"text":117,"@type":113},"Liquid biopsy is described as an innovative approach increasingly used to detect malignant tumors. Cell-free DNA assay-based liquid biopsies may delineate tumor heterogeneity and track tumor recurrence.",{"name":119,"@type":110,"acceptedAnswer":120},"How does cell-free DNA methylation profiling support early screening and prognosis evaluation?",{"text":121,"@type":113},"DNA methylation is presented as an epigenetic modification influencing cancer processes, particularly in early phases. The review states that cell-free DNA methylation profiling is a sensitive, non-invasive technique that can help identify biological origins, enable early screening, and support recurrence monitoring and prognostic assessment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330658,1791353971,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Ovarian Cancer Diagnosis and Prognosis Based on Cell-Free DNA Methylation  \nYajuan Gao 1 􀀁, Nanyang Zhou2 􀀁, and Jie Liu1 􀀁  \nCancer Control Volume 31: 1–16  \n© The Author(s) 2024  \nArticle reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)  \n[DOI: 10.1177/10732748241255548](DOI: 10.1177/10732748241255548)[ ](DOI: 10.1177/10732748241255548)[journals.sagepub.com/home/ccx](journals.sagepub.com/home/ccx)  \nAbstract  \nBackground: Ovarian cancer stands as the deadliest malignant tumor within the female reproductive tract. As a result of the absence of effective diagnostic and monitoring markers, 75% of ovarian cancer cases are diagnosed at a late stage, leading to a mere 50% survival rate within five years. The advancement of molecular biology is essential for accurate diagnosis and treatment of ovarian cancer. Methods: Areview of several randomized clinical trials, focusing on the ovarian cancer, was undertaken. The advancement of molecular biology and diagnostic methods related to accurate diagnosis and treatment of ovarian cancer were examined. Results: Liquid biopsy is an innovative method of detecting malignant tumors that has gained increasing attention over the past few years. Cellfree DNA assay-based liquid biopsies show potential in delineating tumor status heterogeneity and tracking tumor recurrence. DNA methylationinfluencesa multitude of biological functions and diseases, especially during the initial phases of cancer. The cell-free DNA methylation profiling system has emerged as a sensitive and non-invasive technique for identifying and detecting the biological origins of cancer. It holds promise as a biomarker, enabling early screening, recurrence monitoring, and prognostic evaluation of cancer. Conclusions: This review evaluates recent advancements and challenges associated with cell-free DNA methylation analysis for the diagnosis, prognosis monitoring, and assessment of therapeutic responses in the management of ovarian cancers, aiming to offer guidance for precise diagnosis and treatment of this disease.  \nPlain language summary  \nOvarian cancer stands as the deadliest malignant tumor within the female reproductive tract. As a result of the absence of effective diagnostic and monitoring markers, 75% of ovarian cancer cases are diagnosed at a late stage, leading to a mere 50% survival rate within five years. Nearly 80% of advanced stages have a poor prognosis or recurrence within five years. Ovarian cancer is linked to a grim long-term prognosis attributable to its elevated mortality and recurrence rates. The advancement of molecular biology and diagnostic methods is essential for accurate diagnosis and treatment of ovarian cancer. Liquid biopsy is an innovative method of detecting malignant tumors that has gained increasing attention over the past few years. Cell-free DNA assay-based liquid biopsies show potential in delineating tumor status heterogeneity and tracking tumor recurrence. DNA methylation represents a prevalent epigenetic modification. DNA methylation influences a multitude of biological functions and diseases, especially during the initial phases of cancer. The cell-free DNA methylation profiling system has emerged asa sensitive and non-invasive technique for identifying and detecting the biological origins of cancer. This review assesses recent progress and obstacles linked to cell-free DNA methylation analysis for diagnosing, prognostic monitoring, and evaluating therapeutic responses in managing ovarian cancers.  \nKeywords  \novarian cancer, cell-free DNA, DNA methylation, diagnosis, prognosis surveillance, response to therapy  \nReceived January 24, 2024. Received revised April 12, 2024. Accepted for publication April 30, 2024.   \nIntroduction  \nOvarian cancer (OC) comprises a diverse range of malignancies originating from ovarian tissue and differ in their clinicopathology, molecular characteristics, and histological origin.1 The Global Cancer Statistics from the Inter","cbCairl9qN6XJClA","https://ap.wps.com/l/cbCairl9qN6XJClA","pdf",1068520,16,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Plain language summary\n# Keywords\n# Introduction","[{\"question\":\"Why is late detection common in ovarian cancer, and what impact does it have on survival?\",\"answer\":\"Most ovarian cancer cases are diagnosed at a late stage due to the absence of effective diagnostic and monitoring markers, leading to low five-year survival. The text links late-stage detection to limited early indicators and overall poor outcomes.\"},{\"question\":\"What role does liquid biopsy play in diagnosing and monitoring ovarian cancer?\",\"answer\":\"Liquid biopsy is described as an innovative approach increasingly used to detect malignant tumors. Cell-free DNA assay-based liquid biopsies may delineate tumor heterogeneity and track tumor recurrence.\"},{\"question\":\"How does cell-free DNA methylation profiling support early screening and prognosis evaluation?\",\"answer\":\"DNA methylation is presented as an epigenetic modification influencing cancer processes, particularly in early phases. The review states that cell-free DNA methylation profiling is a sensitive, non-invasive technique that can help identify biological origins, enable early screening, and support recurrence monitoring and prognostic assessment.\"}]","Ovarian Cancer Diagnosis and Prognosis Based on Cell-Free DNA Methylation | PDF",1789989663]