[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-228390-en":3,"doc-seo-228390-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},228390,687197207639,"Asher","https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd",8,"Research & Report","Outcomes of Therapeutic Keratoplasty for Severe Infectious Keratitis in Chongqing - A 16-Year Experience","This retrospective study evaluates outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing over a 16-year period. Records of 561 eyes undergoing surgery for refractory microbial keratitis (2001–2016) were analyzed for demographics, microbiology, preoperative status, graft size, complications, and anatomical results. Anatomical success was achieved in 87.7% of eyes. Bacterial keratitis showed better outcomes than fungal or mixed infections, while diabetes and preoperative time ≥30 days were linked to anatomical failure. Larger grafts and surgical delay increased postoperative complications.","Infection and Drug Resistance downloaded from [https://www.dovepress.com/](https://www.dovepress.com/)  \nFor personal use only.  \nInfection and Drug Resistance Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article ORIGINAL RE SE ARCH  \nOutcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing, a 16-year experience  \nThis article was published in the following Dove Press journal:  \nInfection and Drug Resistance  \nQi Zhang 1  \nMin Zhao 1  \nMei Xu 1  \nFengjuan Gu 1  \nQuan Liu 1  \nYuan Chen2  \nHaiqi Zhang 1  \nAize Kijlstra 3  \n1 The First Affiliated Hospital of Chongqing Medical University, Department of Ophthalmology, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People’s Republic of China; 2Chongqing Vision Institute, Chongqing, People’s Republic of China; 3University Eye Clinic Maastricht, Maastricht, the Netherlands  \nCorrespondence: Min Zhao  \nThe First Affiliated Hospital of Chongqing Medical University, Department of Ophthalmology, 1 YouYi Road, YuZhong District, Chongqing 400016, People’s Republic of China  \nTel +86 238 901 3169  \nEmail [eyedoctorz@126.com](eyedoctorz@126.com)  \nPurpose: This study aimed to evaluate the outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing (Southwest China) .  \nPatients and methods: The records of 561 eyes that underwent therapeutic keratoplasty for refractory microbial keratitis from 2001 to 2016 were analyzed in this retrospective study. Data included demographic information, microbiological investigations, associated factors, graft size, preoperative status, postoperative complications, and final anatomical outcomes. Results: Trauma was the most common cause (267, 47.6%) for corneal ulcers leading to therapeutic keratoplasty. The etiological diagnosis included bacterial keratitis (80 eyes, 14.3%), fungal keratitis (317 eyes, 56.5%), acanthamoeba keratitis (3 eyes, 0.5%), and mixed bacteria/fungal infection (15 eyes, 2.7%) . Anatomical success was achieved for 492 eyes (87.7%), with bacterial keratitis having a better outcome than fungal and mixed infections. Diabetes and preoperative time ≥30 days were significantly associated with anatomical failure in the multivariate logistic regression (P=0.028 and P=0.022, respectively) . Patients with hypopyon, corneal perforation, surgical delay, and/or large graft size had a higher incidence of postoperative complications (reinfection, cataract, glaucoma, hyphema, or graft rejection) (P\u003C0.05) .  \nConclusion: Therapeutic keratoplasty was an effective procedure in managing refractory infectious keratitis. Prompt and appropriate surgery would result in fewer complications and better outcomes.  \nKeywords: therapeutic keratoplasty, infectious keratitis, corneal ulcer  \nIntroduction  \nInfectious keratitis is an important cause of visual impairment and blindness worldwide, especially in developing countries.1 Without prompt and appropriate treatment, the severe infection may result in wide range of corneal infiltration, extensive anterior chamber reaction, perforation, and endophthalmitis possibly leading toenucleation.1–4 The presentation and outcomes of infectious keratitis may depend on different region and epidemiology, thus necessitating studies to be performed throughout the world.5 An analysis of the management for severe infectious keratitis in Southwest China has not yet been reported on a large scale, that was one of the reasons for performing this study. Therapeutic keratoplasty (TKP) for severe infectious keratitis accounts about 29.9% of all grafts operated at our ophthalmology center for cornea transplantations in Chongqing, with the patient population from Southwest China. The primary goal of TKP is to save the eyeball  \n[submit your manuscript](submit your manuscript | www.dovepress.com)[ | www.dovepress.com](submit your manuscript | www.dovepress.com)[ ](submit your manuscript | www.dovepress.com)DovePress      \n[http","cbCaibGRE2ETwXZz","https://ap.wps.com/l/cbCaibGRE2ETwXZz","pdf",241254,1,7,"English","en",105,"# Introduction\n# Materials and methods\n# Results\n# Conclusion","[{\"question\":\"What is the purpose of this study on therapeutic keratoplasty?\",\"answer\":\"To evaluate outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing (Southwest China).\"},{\"question\":\"How many eyes were included and what period did the study cover?\",\"answer\":\"A total of 561 eyes were analyzed, covering surgeries performed from 2001 to 2016 (16-year experience).\"},{\"question\":\"Which factors were associated with anatomical failure and postoperative complications?\",\"answer\":\"Diabetes and preoperative time ≥30 days were significantly associated with anatomical failure. Hypopyon, corneal perforation, surgical delay, and/or large graft size were linked to higher postoperative complication rates.\"}]","Outcomes of Therapeutic Keratoplasty for Severe Infectious Keratitis in Chongqing - A 16-Year Experience | PDF",1789025285,18,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"outcomes-of-therapeutic-keratoplasty-for-severe-infectious-keratitis-in-chongqing-a-16-year-experience","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/research-report/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/outcomes-of-therapeutic-keratoplasty-for-severe-infectious-keratitis-in-chongqing-a-16-year-experience/228390/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-09-11","2026-09-10",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"What is the purpose of this study on therapeutic keratoplasty?","Question",{"text":76,"@type":77},"To evaluate outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing (Southwest China).","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"How many eyes were included and what period did the study cover?",{"text":81,"@type":77},"A total of 561 eyes were analyzed, covering surgeries performed from 2001 to 2016 (16-year experience).",{"name":83,"@type":74,"acceptedAnswer":84},"Which factors were associated with anatomical failure and postoperative complications?",{"text":85,"@type":77},"Diabetes and preoperative time ≥30 days were significantly associated with anatomical failure. Hypopyon, corneal perforation, surgical delay, and/or large graft size were linked to higher postoperative complication rates.","https://schema.org",{"og:url":52,"og:type":88,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":90,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":93},[94,98,102,106,111,116,120,123,128,131,135],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":95,"show_sort_weight":96,"slug":97},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":99,"show_sort_weight":100,"slug":101},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":103,"show_sort_weight":104,"slug":105},"Exam",70,"exam",{"id":107,"doc_module":4,"doc_module_name":46,"category_name":108,"show_sort_weight":109,"slug":110},5,"Comic",60,"comic",{"id":112,"doc_module":4,"doc_module_name":46,"category_name":113,"show_sort_weight":114,"slug":115},6,"Technology",50,"technology",{"id":21,"doc_module":4,"doc_module_name":46,"category_name":117,"show_sort_weight":118,"slug":119},"Healthcare",40,"healthcare",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":121,"slug":122},30,"research-report",{"id":124,"doc_module":4,"doc_module_name":46,"category_name":125,"show_sort_weight":126,"slug":127},9,"Religion & Spirituality",20,"religion-spirituality",{"id":126,"doc_module":4,"doc_module_name":46,"category_name":129,"show_sort_weight":126,"slug":130},"World Cup","world-cup",{"id":132,"doc_module":4,"doc_module_name":46,"category_name":133,"show_sort_weight":132,"slug":134},10,"Lifestyle","lifestyle",{"id":136,"doc_module":4,"doc_module_name":46,"category_name":137,"show_sort_weight":107,"slug":138},19,"General","general"]