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Advancing targeted therapies requires a detailed understanding of molecular resistance mechanisms. Evidence from exercise-oncology suggests physical activity is linked to reduced recurrence and mortality, supporting benefits across prevention, treatment, and post-treatment phases. Increased physical activity versus reduced activity in patients undergoing chemotherapy, radiotherapy, and surgery highlights exercise’s role in comprehensive care and improving treatment efficacy by modulating biological pathways.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/outcomes-of-physical-exercises-on-initiation-progression-and-treatment-of-breast-cancer-review/342767/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/outcomes-of-physical-exercises-on-initiation-progression-and-treatment-of-breast-cancer-review/342767.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is drug resistance a central obstacle in breast cancer treatment?","Question",{"text":112,"@type":113},"Drug resistance significantly limits the effectiveness of breast cancer therapies and is described as a primary contributor to cancer-related fatalities worldwide.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does physical activity relate to breast cancer prevention and outcomes?",{"text":117,"@type":113},"Participation in physical activity is associated with decreased reappearance and fatality rates, and is reported to yield favorable outcomes in prevention, treatment, and post-treatment phases.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the review’s focus regarding exercise and breast cancer?",{"text":121,"@type":113},"The review summarizes current literature on how physical activity influences the occurrence and progression of breast cancer, including effects during chemotherapy, radiotherapy, and surgery.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},342767,1790243451,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Xu etal. Cell Communication and Signaling (2024) 22:260  \n[https://doi.org/10.1186/s12964-024-01634-6](https://doi.org/10.1186/s12964-024-01634-6)  \nCell Communication and Signaling  \nREVIEW Open Access  \nOutcomes of physical exercises on initiation,  progression, and treatment of breast cancer  \nJunwei Xu 1*, Xiance Jiao2 and Reyhaneh Bayat3*  \nAbstract  \nThe emergence of drug resistance is a substantial obstacle to the effective management of breast cancer, which is the primary cause of cancer-related deaths in women worldwide. To facilitate the development of targeted therapies that can effectively overcome drug resistance, it is crucial to possess a comprehensive comprehension of the molecular mechanisms that underpin resistance to breast cancer treatment. So far, considerable progress has been made in the field of exercise-oncology research and overcome drug resistance, specifically about breast cancer. Evidence has suggested that participation in physical activity is correlated with a decrease in reappearance and fatality rates of breast cancer patients. It has been reported that participation in physical activity can yield favorable outcomes in the prevention, treatment, and post-treatment of breast cancer. An increasing body of empirical evidence suggests that participation in physical activity can alter diverse biological mechanisms, potentially augmenting breast cancer treatments’ efficacy. Comparing increased physical activity versus reduced physical activity in breast cancer patients who received chemotherapy, radiotherapy, and surgery supported the significance of exercise in comprehensive care strategies to enhance overall health and treatment efficacy. Furthermore, previous studies have reported that physical activity can enhance the efficacy of breast cancer treatments. This review provides the current literature regarding the influence of physical activity on the occurrence and progression of breast cancer.  \nKeywords Breast cancer, Physical exercises, Cancer therapy, Resistance  \n*Correspondence:  \nJunwei Xu [JunweiXu76@outlook.com](JunweiXu76@outlook.com)[ ](JunweiXu76@outlook.com)Reyhaneh Bayat  \n[reyhanehbayat2007@yahoo.com](reyhanehbayat2007@yahoo.com); [Aliciaairplane854@hotmail.com](Aliciaairplane854@hotmail.com)  \n1Physical education institute, Henan University of Economics and Law, Zhengzhou, China  \n2College of Continuing Education, Henan Quality Polytechnic, Pingdingshan, China  \n3Department of General Surgery, Shahid Beheshti University of Medical Science and Health Services, Taleghani Hospital, Tehran, Iran  \nIntroduction  \nBreast cancer is a common malignancy in women worldwide, with an estimated 2.3 million new cases projected for the year 2020. This figure represents approximately 24.5% of the total number of cancer diagnoses [1]. The median survival rate for metastatic breast cancer, characterized by the presence of breast cancer in distant sites from the breast and lymph nodes, has demonstrated a substantial rise from 4 to 30% within the previous two decades [2]. The therapeutic objectives for metastatic breast cancer encompass extension of life expectancy, increase of quality of life, and management of symptoms [3, 4]. The determination of appropriate treatment modalities for metastatic breast cancer is contingent upon a multitude of factors, including precise anatomical  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and ","cbCair2GzXAINOgj","https://ap.wps.com/l/cbCair2GzXAINOgj","pdf",2539449,12,"English","# Abstract\n# Introduction\n## Challenges in breast cancer treatment\n## Role of physical activity in outcomes\n## Exercise-oncology implications","[{\"question\":\"Why is drug resistance a central obstacle in breast cancer treatment?\",\"answer\":\"Drug resistance significantly limits the effectiveness of breast cancer therapies and is described as a primary contributor to cancer-related fatalities worldwide.\"},{\"question\":\"How does physical activity relate to breast cancer prevention and outcomes?\",\"answer\":\"Participation in physical activity is associated with decreased reappearance and fatality rates, and is reported to yield favorable outcomes in prevention, treatment, and post-treatment phases.\"},{\"question\":\"What is the review’s focus regarding exercise and breast cancer?\",\"answer\":\"The review summarizes current literature on how physical activity influences the occurrence and progression of breast cancer, including effects during chemotherapy, radiotherapy, and surgery.\"}]","Outcomes of physical exercises on initiation, progression, and treatment of breast cancer - Review | PDF",1790048118]