[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-384064-en":3,"doc-seo-384064-105":30,"detail-sidebar-cat-0-en-105":98},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":20,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},384064,1374404737137,"Adam","https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d",7,"Healthcare","Outcomes of Patients with Gastrointestinal Stromal Tumors in the Past Decade","Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal tract mesenchymal neoplasms, leaving limited knowledge about overall epidemiology and prognostic pathology factors. This study evaluates independent determinants of mortality in patients diagnosed with GISTs across the past decade using SEER data. The analysis includes baseline characteristics and compares overall mortality and cancer-specific mortality via Cox regression to identify independent predictors of death. Results highlight significant associations with demographics, disease stage, and treatment-related outcomes.","medical sciences  \nArticle  \nOutcomes of Patients with Gastrointestinal Stromal Tumors in the Past Decade  \nAyrton Bangolo 1, *, Pierre Fwelo 2, Tha'er Al-Qatish 1, John Bukasa-Kakamba 3, Tiffany Lee 1, Akira G. Cayago 1, Sarah Potiguara 1, Vignesh K. Nagesh 1, Jessica Kawall 1, Rashid Ahmed 1, Muhammad Asjad Abbas 1,  \nNarissa Nursjamsi 1, Stacy H. Lee 1, Shagi Meti 1, Georgemar V. Arana 1, Chrishanti A. Joseph 1,  \nAbdifitah Mohamed 4, Arthur Alencar 1, Huzaifa G. Hassan 1, Pramanu Aryal 1, Aleena Javed 1, Maksim Kalinin 1, Gbenga Lawal 1, Ibtihal Y. Khalaf 1, Midhun Mathew 1, Praveena Karamthoti 1, Bhavna Gupta 5  \nand Simcha Weissman 1  \nCitation: Bangolo, A.; Fwelo, P.; Al-Qatish, T.; Bukasa-Kakamba, J.; Lee, T.; Cayago, A.G.; Potiguara, S.; Nagesh, V.K.; Kawall, J.; Ahmed, R.; et al. Outcomes of Patients with Gastrointestinal Stromal Tumors in the Past Decade. Med. Sci. 2023, 11, 54. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)medsci11030054  \nAcademic Editors: Tracy  \nMurray-Stewart and Antoni Torres  \nReceived: 3 July 2023  \nRevised: 10 August 2023  \nAccepted: 25 August 2023  \nPublished: 28 August 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Medicine, Hackensack Meridian Health/Palisades Medical Center, North Bergen, NJ 07047, USA; [thaerq@gmail.com](thaerq@gmail.com) (T.A.-Q.); [sarahp@gmail.com](sarahp@gmail.com) (S.P.); [georgemarara@gmail.com](georgemarara@gmail.com) (G.V.A.); [chrishantijo@gmail.com](chrishantijo@gmail.com) (C.A.J.); [maksika@gmail.com](maksika@gmail.com) (M.K.); [gbengala@gmail.com](gbengala@gmail.com) (G.L.); [ibtihalkal@gmail.com](ibtihalkal@gmail.com) (I.Y.K.)  \n2 Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, TX 77204, USA  \n3 Division of Endocrinology, Department of Medicine, Kinshasa University Clinics, Kinshasa 7948, Democratic Republic of the Congo; [johnbukasa73@gmail.com](johnbukasa73@gmail.com)  \n4 Department of Medicine, University of Washington, Seattle, WA 98195, USA  \n5 Division of Hematology and Oncology, Department of Medicine, Hackensack Meridian Health/Palisades Medical Center, North Bergen, NJ 07047, USA  \n* Correspondence: [ayrtonbangolo@yahoo.com](ayrtonbangolo@yahoo.com)  \nAbstract: Background: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms of the gastrointestinal tract (GIT) that represent approximately 1 to 2 percent of primary gastrointestinal (GI) cancers. Owing to their rarity, very little is known about their overall epidemiology, and the prognostic factors of their pathology. The current study aimed to evaluate the independent determinants of mortality in patients diagnosed with GISTs over the past decade. Methods: Our study comprised 2374 patients diagnosed with GISTs from 2000 to 2017 from the Surveillance, Epidemiology, and End Results (SEER) database. We analyzed the baseline characteristics, and overall mortality (OM), as well as the cancer-specific mortality (CSM) of GISTs. Variables with a p value \u003C 0.01 in the univariate Cox regression were incorporated into the multivariate Cox model, to determine the independent prognostic factors. Results: Multivariate Cox proportional hazard regression analyses of factors affecting the all-cause mortality and GIST-related mortality among US patients between 2010 and 2017 revealed a higher overall mortality in non-Hispanic Black patients (HR = 1.516, 95% CI 1.172–1.961, p = 0.002), patients aged 80+ (HR = 9.783, 95% CI 4.185–22.868, p = 0), followed by those aged 60–79 (HR = 3.408, 95% CI 1.488–7.807, p = 0.004); male patients (HR = 1.795, 95% CI 1.461–2.206, p \u003C 0.00","cbCaimukb9r1iVaX","https://ap.wps.com/l/cbCaimukb9r1iVaX","pdf",261486,12,1,"English","en",105,"# Introduction\n# Materials and Methods\n## Data Source and Study Cohort\n## Statistical Analysis\n# Results\n## Overall Mortality\n## Cancer-Specific Mortality\n# Discussion\n# Conclusions","[{\"question\":\"What was the main objective of the study on gastrointestinal stromal tumors (GISTs)?\",\"answer\":\"To evaluate the independent determinants of mortality in patients diagnosed with GISTs over the past decade.\"},{\"question\":\"How many patients and what years were included in the SEER-based analysis?\",\"answer\":\"The study analyzed 2,374 patients diagnosed with GISTs from 2000 to 2017 in the SEER database.\"},{\"question\":\"Which patient and disease factors were associated with higher mortality in the study?\",\"answer\":\"Higher mortality was associated with non-Hispanic Black race, male sex, older age (especially 80+), and advanced disease with distant metastasis or regional involvement, and widowed status; the study also reported chemotherapy-related higher cancer-specific mortality.\"}]","Outcomes of Patients with Gastrointestinal Stromal Tumors in the Past Decade | PDF",1790261049,30,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":92,"head_meta":94,"extra_data":96,"updated_unix":97},"outcomes-of-patients-with-gastrointestinal-stromal-tumors-in-the-past-decade","",{"@graph":36,"@context":91},[37,54,74],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/outcomes-of-patients-with-gastrointestinal-stromal-tumors-in-the-past-decade/384064/",4,{"url":52,"name":13,"@type":55,"image":56,"author":61,"headline":13,"publisher":63,"fileFormat":66,"inLanguage":23,"description":14,"dateModified":67,"datePublished":68,"encodingFormat":66,"isAccessibleForFree":69,"interactionStatistic":70},"DigitalDocument",{"url":57,"@type":58,"width":59,"height":60},"https://docshare.wps.com/thumbnails/outcomes-of-patients-with-gastrointestinal-stromal-tumors-in-the-past-decade/384064.png","ImageObject",300,407,{"name":9,"@type":62},"Person",{"url":41,"name":64,"@type":65},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":71,"interactionType":72,"userInteractionCount":20},"InteractionCounter",{"@type":73},"ViewAction",{"@type":75,"mainEntity":76},"FAQPage",[77,83,87],{"name":78,"@type":79,"acceptedAnswer":80},"What was the main objective of the study on gastrointestinal stromal tumors (GISTs)?","Question",{"text":81,"@type":82},"To evaluate the independent determinants of mortality in patients diagnosed with GISTs over the past decade.","Answer",{"name":84,"@type":79,"acceptedAnswer":85},"How many patients and what years were included in the SEER-based analysis?",{"text":86,"@type":82},"The study analyzed 2,374 patients diagnosed with GISTs from 2000 to 2017 in the SEER database.",{"name":88,"@type":79,"acceptedAnswer":89},"Which patient and disease factors were associated with higher mortality in the study?",{"text":90,"@type":82},"Higher mortality was associated with non-Hispanic Black race, male sex, older age (especially 80+), and advanced disease with distant metastasis or regional involvement, and widowed status; 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