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Methods: Using the 2012–2020 National Inpatient Sample, all adults undergoing major cancer resections were identified and entropy balancing, with multivariable models, was used to compare outcomes. Results: Among 905,830 patients, 1,480 had concomitant CHD. After adjustment, CHD increased in-hospital mortality and stroke risk, prolonged stays, and raised hospitalization costs. Conclusions: CHD is linked with inferior clinical and financial outcomes after cancer resection.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/outcomes-following-major-thoracoabdominal-cancer-resection-in-adults-with-congenital-heart-disease/340820/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/outcomes-following-major-thoracoabdominal-cancer-resection-in-adults-with-congenital-heart-disease/340820.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study background and motivation?","Question",{"text":112,"@type":113},"Adult patients with congenital heart disease increasingly present with non-cardiovascular malignancies, and while thoracoabdominal cancer surgery is common, outcomes for this population were not well established.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients and comparisons conducted?",{"text":117,"@type":113},"The 2012–2020 National Inpatient Sample was queried for adults undergoing major cancer resections, and entropy balancing plus multivariable models were used to adjust for baseline differences.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcomes were worse for patients with CHD after risk adjustment?",{"text":121,"@type":113},"CHD was associated with higher in-hospital mortality and increased odds of stroke, along with longer hospitalization duration and greater hospitalization expenditures.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340820,1790258462,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","PLOS ONE  \nOPEN ACCESS  \nCitation: Sakowitz S, Bakhtiyar SS, Ali K, Mallick S, Williamson C, Benharash P (2024) Outcomes following major thoracoabdominal cancer resection in adults with congenital heart disease. PLoS ONE 19(1): e0295767 . [https://doi.org/10.1371/journal](https://doi.org/10.1371/journal). pone.0295767  \nEditor: Hiraku Kumamaru, The University of Tokyo Graduate School of Medicine, JAPAN  \nReceived: May 3, 2023  \nAccepted: November 28, 2023  \nPublished: January 2, 2024  \nCopyright: © 2024 Sakowitz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: Data are available upon direct request to the Agency for Healthcare Research and Quality (contact via www.hcup-us. [ahrq.gov](ahrq.gov)) for researchers who meet the criteria for access and complete a Data Use Agreement. The authors of this study have no special access privileges unavailable to others. Data cannot be shared directly by the authors as completion of a Data Use Agreement is required by the Agency for Healthcare Research and Quality. Data Use Agreements are available at [https://www.hcup-us](https://www.hcup-us). [ahrq.gov/team/NationwideDUA.jsp](ahrq.gov/team/NationwideDUA.jsp for all)[ for all](ahrq.gov/team/NationwideDUA.jsp for all) interested  \nRESEARCH ARTICLE  \nOutcomes following major thoracoabdominal cancer resection in adults with congenital heart disease  \nSara Sakowitz1☯, Syed Shahyan Bakhtiyar1,2☯, Konmal Ali1, Saad Mallick1, Catherine Williamson1, Peyman Benharash1,3 *  \n1 Cardiovascular Outcomes Research Laboratories (CORELAB), University of California, Los Angeles, CA, United States of America, 2 Department of Surgery, University of Colorado, Aurora, CO, United States of America, 3 Department of Surgery, University of California, Los Angeles, CA, United States of America  \n☯ These authors contributed equally to this work.  \n* [pbenharash@mednet.ucla.edu](pbenharash@mednet.ucla.edu)  \nAbstract  \nBackground  \nWhile advances in medical and surgical management have allowed >97% of congenital heart disease (CHD) patients to reach adulthood, a growing number are presenting with non-cardiovascular malignancies. Indeed, adults with CHD are reported to face a 20% increase in cancer risk, relative to others, and cancer has become the fourth leading cause of death among this population. Surgical resection remains a mainstay in management of thoracoabdominal cancers. However, outcomes following cancer resection among these patients have not been well established. Thus, we sought to characterize clinical and financial outcomes following major cancer resections among adult CHD patients.  \nMethods  \nThe 2012–2020 National Inpatient Sample was queried for all adults (CHD or non-CHD) undergoing lobectomy, esophagectomy, gastrectomy, pancreatectomy, hepatectomy, or colectomy for cancer. To adjust for intergroup differences in baseline characteristics, entropy balancing was applied to generate balanced patient groups. Multivariable models were constructed to assess outcomes of interest.  \nResults  \nOf 905,830 patients undergoing cancer resection, 1,480 (0 .2%) had concomitant CHD. The overall prevalence of such patients increased from \u003C0. 1% in 2012 to 0 .3% in 2012 (P for trend\u003C0.001) . Following risk adjustment, CHD was linked with greater in-hospital mortality (AOR 2 .00, 95%CI 1.06–3.76), as well as a notable increase in odds of stroke (AOR 8 .94, 95%CI 4.54–17.60), but no statistically significant difference in cardiac (AOR 1.33, 95%CI 0.69–2.59) or renal complications (AOR 1.35, 95%CI 0.92–1.97) . Further, CHD was associated with a +2.39 day incremental increase in duration of hospitalization (95%CI +1 .04–  \nparties and can be submitted to the Healthcare Cost and Utilization Project Central Distributor through email [at](at HCUP@AHRQ","cbCaiq12AZOjNE4m","https://ap.wps.com/l/cbCaiq12AZOjNE4m","pdf",1289903,12,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the study background and motivation?\",\"answer\":\"Adult patients with congenital heart disease increasingly present with non-cardiovascular malignancies, and while thoracoabdominal cancer surgery is common, outcomes for this population were not well established.\"},{\"question\":\"How were patients and comparisons conducted?\",\"answer\":\"The 2012–2020 National Inpatient Sample was queried for adults undergoing major cancer resections, and entropy balancing plus multivariable models were used to adjust for baseline differences.\"},{\"question\":\"What outcomes were worse for patients with CHD after risk adjustment?\",\"answer\":\"CHD was associated with higher in-hospital mortality and increased odds of stroke, along with longer hospitalization duration and greater hospitalization expenditures.\"}]","Outcomes following major thoracoabdominal cancer resection in adults with congenital heart disease | PDF",1790039041]