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Methods retrospectively review 63 adults treated from 1994–2023 with 3D-conformal fast neutron therapy or IMNT for localized M0/M1 disease. Results report 5-year LRFS of 53.4% and 5-year overall survival of 75.1%, with acceptable swallowing outcomes and low persistent PEG dependence. Conclusions support significant locoregional control and suggest IMNT may further improve therapeutic ratio and function.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/outcomes-after-fast-neutron-therapy-for-locally-advanced-base-of-tongue-adenoid-cystic-carcinoma/415815/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/outcomes-after-fast-neutron-therapy-for-locally-advanced-base-of-tongue-adenoid-cystic-carcinoma/415815.png","ImageObject",300,407,{"name":92,"@type":93},"Aditya","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What clinical problem does the study address?","Question",{"text":112,"@type":113},"The study addresses outcomes for base of tongue adenoid cystic carcinoma, a rare malignancy with high local recurrence and limited effectiveness of surgery alone or conventional therapies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients treated in this retrospective review?",{"text":117,"@type":113},"Between 1994 and 2023, 63 biopsy-confirmed adults received 3D-conformal fast neutron therapy or intensity-modulated neutron therapy for localized M0 or M1 disease.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key outcomes for tumor control and survival?",{"text":121,"@type":113},"For the full cohort, 5-year locoregional recurrence-free survival was 53.4% and 5-year overall survival was 75.1%, with stronger control patterns described for M0 patients.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},415815,1790792662,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962085564549,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","International Journal of Particle Therapy 19 (2026) 101214  \nContents lists available at ScienceDirect  \nInternational Journal of Particle Therapy  \njournal [homepage:](homepage: www.sciencedirect.com/journal/ijpt)[ www.sciencedirect.com/journal/ijpt](homepage: www.sciencedirect.com/journal/ijpt)  \nOutcomes After Fast Neutron Therapy for Locally Advanced Base of Tongue Adenoid Cystic Carcinoma  \nAnthony K. Heng1, August Anderson2, Robert D. Stewart2, George E. Laramore2, Neil Panjwani2, Cristina P. Rodriguez3, Lauren Shih3, Neal Futran4, Brittany Barber4, Emily Marchiano4, Rocco Ferrandino4, Upendra Parvathaneni5, Jay J. Liao2,⁎  \n1 University of Washington School of Medicine, Seattle, WA, USA  \n2 Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA  \n3 Division of Hematology & Oncology, University of Washington School of Medicine, Seattle, WA, USA  \n4 Department of Otolaryngology Head & Neck Surgery, University of Washington School of Medicine, Seattle, WA, USA  \n5 Department of Radiation Oncology, University of Texas Medical Branch, Galveston, TX, USA  \nA R T I C L E I N F O  \nKeywords:  \nNeutron radiotherapy Neutrons  \nAdenoid cystic carcinoma Base of tongue  \nRBE  \nA B S T R A C T  \nPurpose: Base of tongue (BOT) adenoid cystic carcinoma (ACC) is a rare, locally aggressive malignancy that is typically associated with a high rate of disease recurrence. Surgery alone is rarely curative and highly morbid. Outcomes of systemic therapies and low linear energy transfer radiation therapy (RT) are generally poor. Fast neutron therapy (NRT), a form of high linear energy transfer radiation, is advantageous in treating radioresistant salivary gland malignancies. Long-term cancer control and swallowing outcomes in patients with BOT ACC treated with NRT were retrospectively reviewed.  \nMethods: Between 1994 and 2023, 63 patients ≥18 years (median age 61) with biopsy-confirmed BOT ACC, not treated previously with surgery or RT, underwent 3D-conformal NRT or intensity-modulated neutron therapy (IMNT) for localized M0 (77.8%) or M1 (22.2%) disease. Most patients had (T3-4) primary tumors. Kaplan-Meier method was used to estimate locoregional recurrence-free (LRFS), distant metastasis-free, and overall survival. Late toxicities (≥90 days after NRT) were reported per Common Terminology Criteria for Adverse Events v5.0. Treatment-related and post-treatment percutaneous endoscopic gastrotomy (PEG) tube utilization was evaluated.  \nResults: For the entire cohort, 5-year LRFS was 53.4%, and 5-year overall survival was 75.1%. Among M0 patients, 3-year LRFS was 72.4%, 5-year LRFS was 59.4%, and 5-year distant metastasis-free was 44.1%. Prophylactic PEG tubes were placed in 58.1% of patients; 14.5% remained PEG-dependent ≥90 days posttreatment. Common toxicities included xerostomia and dysphagia. Among evaluable patients, 33.3% required PEG placement after 90 days due to disease or salvage therapy. Neither patient treated with IMNT required longterm PEG use.  \nConclusions: This is the first study to report clinical outcomes of NRT for BOT ACC. Swallowing outcomes were acceptable, with a low rate of persistent PEG dependence. NRT achieved significant locoregional control in many locally advanced primary tumors. Additional improvements in the therapeutic ratio and functional outcomes may be achievable with IMNT.  \nIntroduction  \nAdenoid cystic carcinoma (ACC) is a rare salivary gland malignancy characterized by aggressive local invasion and predilection for local recurrence, perineural spread, and distant metastasis. ACC often has an indolent natural history, but there is also risk of high-grade transformation  \nassociated with more aggressive clinical course. ACC accounts for approximately 10% of salivary malignancies (∼1200 per year in the US).1 Treatment typically involves complete surgical resection followed by postoperative radiotherapy in those with resectable disease. Radiotherapy alone is used for pa","cbCaieIrW5o2BYl7","https://ap.wps.com/l/cbCaieIrW5o2BYl7","pdf",3562187,"English","# Purpose\n# Methods\n# Results\n# Conclusions\n# Introduction","[{\"question\":\"What clinical problem does the study address?\",\"answer\":\"The study addresses outcomes for base of tongue adenoid cystic carcinoma, a rare malignancy with high local recurrence and limited effectiveness of surgery alone or conventional therapies.\"},{\"question\":\"How were patients treated in this retrospective review?\",\"answer\":\"Between 1994 and 2023, 63 biopsy-confirmed adults received 3D-conformal fast neutron therapy or intensity-modulated neutron therapy for localized M0 or M1 disease.\"},{\"question\":\"What were the key outcomes for tumor control and survival?\",\"answer\":\"For the full cohort, 5-year locoregional recurrence-free survival was 53.4% and 5-year overall survival was 75.1%, with stronger control patterns described for M0 patients.\"}]","Outcomes After Fast Neutron Therapy for Locally Advanced Base of Tongue Adenoid Cystic Carcinoma | PDF",1790602999,23]