[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-440766-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-440766-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","outcome-of-peritonitis-in-automated-peritoneal-dialysis-a-cohort-study","Outcome of Peritonitis in Automated Peritoneal Dialysis - A Cohort Study","","Peritoneal dialysis–associated peritonitis is a severe complication in PD, and treatment guidance has been largely shaped for continuous ambulatory PD (CAPD) rather than automated PD (APD). This single-center retrospective cohort study compared bacteriology and treatment outcomes across 176 APD peritonitis episodes and 352 matched CAPD episodes. For APD cases, it also evaluated clinical differences between intermittent versus continuous intraperitoneal antibiotic dosing. APD showed higher complete cure rates, and intermittent dosing yielded better primary response and complete cure outcomes than continuous regimens.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/outcome-of-peritonitis-in-automated-peritoneal-dialysis-a-cohort-study/440766/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/outcome-of-peritonitis-in-automated-peritoneal-dialysis-a-cohort-study/440766.png","ImageObject",300,407,{"name":42,"@type":43},"Himbo","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"How were APD and CAPD peritonitis episodes compared in the study?","Question",{"text":62,"@type":63},"The study used a single-center retrospective cohort design, comparing 176 APD peritonitis episodes with 352 CAPD episodes matched for age, sex, and diabetes status.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What was the primary outcome?",{"text":67,"@type":63},"The primary outcome was the rate of complete cure.",{"name":69,"@type":60,"acceptedAnswer":70},"Did intraperitoneal antibiotic dosing differ in outcomes for APD patients?",{"text":71,"@type":63},"Yes. In the APD group, intermittent dosing showed significantly better primary response rates and complete cure rates than continuous regimens.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},440766,1790740324,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":106,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Original Research  \nOutcome of Peritonitis in Automated Peritoneal Dialysis: A Cohort Study  \nAmelia Chien-Wei Chao, Jack Kit-Chung Ng, Sam Lik-Fung Lau, Winston Wing-Shing Fung, Gordon Chan-Kau Chan, Phyllis Mei-Shan Cheng, Wing-Fai Pang, Kai-Ming Chow,  \nPhilip Kam-Tao Li, and Cheuk-Chun Szeto  \nRational & Objectives: Peritonitis is a serious complication of peritoneal dialysis (PD) . Current treatment guidelines are directed toward patients receiving continuous ambulatory PD (CAPD), whereas the optimal treatment for those receiving automated PD (APD) is less clear. In this study, we compared the bacteriology and treatment outcomes of peritonitis episodes between patients receiving APD and CAPD and, for peritonitis episodes in patients receiving APD, we studied the difference in clinical outcomes between intermittent and continuous dosing of intraperitoneal antibiotics.  \nStudy Design: Single-center, retrospective cohort study.  \nSetting & Participants: One hundred and seventy-six APD peritonitis episodes from 2007 to 2021 were compared to 352 CAPD episodes, matched for age, sex, and diabetes status. Exposures: Mode of PD; intermittent versus continuous dosing of intraperitoneal antibiotics. Outcomes: Primary outcome was the rate of complete cure.  \nAnalytical Approach: Groups were compared byχ2 test, Mann-Whitney U test, t test, or Fisher exact test.  \nResults: The APD group had higher complete cure rates than the CAPD group (88% vs 81 %, P = 0.033), but primary response rates were similar. Patients receiving nocturnal intermittent peritoneal dialysis had significantly higher primary response rates (91 % vs 80%, P = 0.03) and complete cure rates (95% vs 79%, P \u003C 0.001) than those receiving continuous cyclic peritoneal dialysis. Within the APD group, patients treated with intermittent dosing of intraperitoneal antibiotics demonstrated significantly better primary response rates (91 % vs 69%, P \u003C 0.001) and complete cure rates (93% vs 74%, P \u003C 0.001) than those converted to CAPD for a continuous regimen.  \nLimitations: Retrospective study; small subgroup size.  \nConclusions: Peritonitis episodes in patients receiving APD had better treatment outcomes than those receiving CAPD. In the APD group, treatment with intermittent dosing of intraperitoneal antibiotics had better primary response rate and complete cure rate than those treated with continuous regimens.  \nComplete author and article information provided before references.  \nCorrespondence to  \nA. C. -W. Chao ([chaoamelia@gmail.com](chaoamelia@gmail.com)) Kidney Med. 8(1):101153. Published online October  \n21, 2025.  \ndoi: 10.1016/j. xkme.2025.101153  \n© 2025 The Authors. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc. This is an open access article under the CC BYNC-ND license ([http://](http://)[ ](http://)[creativecommons.org/](creativecommons.org/)[ ](creativecommons.org/)[licenses/by-nc-nd/4.0/](licenses/by-nc-nd/4.0/)).  \nPeritoneal dialysis (PD) is an important form of home  \nbased kidney replacement therapy. It allows patients to maintain quality of life while better preserving residual kidney function compared with hemodialysis. 1-4 It is also more cost effective with a lower requirement for infrastructure.5 , 6 There are 2 modalities of PD, namely, continuous ambulatory PD (CAPD) and machine-assisted automated PD (APD), each with their own advantagesand disadvantages. The benefits of APD include flexible scheduling, reduced pressure-and flow-related symptoms, and probably a superior quality of life. 1  \nDespite the advances in technology, peritonitis remains a common yet devastating complication in the PD population, with a myriad of consequences including loss of ultrafiltration, membrane failure, transfer to hemodialysis, higher morbidity and mortality, and increased health care costs.7 , 8 It is generally believed that the peritonitis rate is lower in APD than CAPD because of the fewer connectionsand manual exchanges required.9 , ","cbCaicJpANu9PiQR","https://ap.wps.com/l/cbCaicJpANu9PiQR","pdf",743353,"English","# Rational & Objectives\n# Study Design\n# Setting & Participants\n# Exposures and Outcomes\n# Analytical Approach\n# Results\n# Limitations\n# Conclusions","[{\"question\":\"How were APD and CAPD peritonitis episodes compared in the study?\",\"answer\":\"The study used a single-center retrospective cohort design, comparing 176 APD peritonitis episodes with 352 CAPD episodes matched for age, sex, and diabetes status.\"},{\"question\":\"What was the primary outcome?\",\"answer\":\"The primary outcome was the rate of complete cure.\"},{\"question\":\"Did intraperitoneal antibiotic dosing differ in outcomes for APD patients?\",\"answer\":\"Yes. In the APD group, intermittent dosing showed significantly better primary response rates and complete cure rates than continuous regimens.\"}]","Outcome of Peritonitis in Automated Peritoneal Dialysis - A Cohort Study | PDF",1790693285,18]