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This study tested whether OA enhances PCa progression by assessing RM1 murine PCa cell proliferation and migration after OA-representing conditioned media, with COMP and IL-1α modulators. OA media increased both proliferation and migration in vitro. In vivo, OA-bearing mice formed tumors in 100% of cases and showed higher tumor burden correlated with OA severity, along with increased Ki-67 expression.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/osteoarthritis-as-a-systemic-disease-promoted-prostate-cancer-in-vivo-and-in-vitro/339515/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/osteoarthritis-as-a-systemic-disease-promoted-prostate-cancer-in-vivo-and-in-vitro/339515.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"What did the in vivo experiments show regarding tumors in OA and non-OA mice?","Question",{"text":112,"@type":113},"Mice with OA developed tumors in 100% of cases, whereas mice without OA developed tumors in 83.4%. 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Smith 1, E. Ann Tallant 4, Bethany A. Kerr 1,3 and Jeffrey S. Willey 2  \nCitation: Rosas, S.; Kwok, A.; Moore, J.; Shi, L.; Smith, T.L.; Tallant, E.A.; Kerr, B.A.; Willey, J.S. Osteoarthritis asa Systemic Disease Promoted Prostate Cancer In Vivo and In Vitro. Int. J. Mol. Sci. 2024, 25, 6014 . [https://doi.org/10.3390/ijms25116014](https://doi.org/10.3390/ijms25116014)  \nAcademic Editor: Alfonso Baldi  \nReceived: 4 May 2024  \nRevised: 28 May 2024  \nAccepted: 28 May 2024  \nPublished: 30 May 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Orthopedic Surgery, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA  \n2 Department of Radiation Oncology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA; [jwilley@wakehealth.edu](jwilley@wakehealth.edu) (J.S.W.)  \n3 Department of Cancer Biology, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA  \n4 Department of Hypertension, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA  \n* Correspondence: [srosas@wakehealth.edu](srosas@wakehealth.edu)  \nAbstract: Osteoarthritis (OA) is increasing worldwide, and previous work found that OA increases systemic cartilage oligomeric matrix protein (COMP), which has also been implicated in prostate cancer (PCa) . As such, we sought to investigate whether OA augments PCa progression. Cellular proliferation and migration of RM1 murine PCa cells treated with interleukin (IL)-1α, COMP, IL-1α + COMP, or conditioned media from cartilage explants treated with IL-1α (representing OA media) and with inhibitors of COMP were assessed. A validated murine model was used for tumor growth and marker expression analysis. Both proliferation and migration were greater in PCa cells treated with OA media compared to controls (p \u003C 0.001), which was not seen with direct application of the stimulants. Migration and proliferation were not negatively affected when OA media was mixed with downstream and COMP inhibitors compared to controls (p > 0.05 for all) . Mice with OA developed tumors 100% of the time, whereas mice without OA only 83.4%(p = 0.478) . Tumor weight correlated with OA severity (Pearson correlation = 0.813, p = 0.002) . Moreover, tumors from mice with OA demonstrated increased Ki-67 expression compared to controls (mean 24.56% vs. 6.91%, p = 0.004) but no difference in CD31, PSMA, or COMP expression (p > 0.05) . OA appears to promote prostate cancer in vitro and in vivo.  \nKeywords: osteoarthritis; prostate cancer; COMP; mouse model; destabilization of the medial meniscus  \n1. Introduction  \nEvaluating comorbidities as modifiers of natural disease progression has gained widespread interest [1–4], which includes considering if/how osteoarthritis (OA) affects the clinical outcomes of patients with prostate cancer (PCa) . Importantly, PCa is a highly prevalent disease in the United States, affecting over 54 million adults and causing over 550,000 deaths annually [5,6] with OA also having a large prevalence in the US. For patients with PCa, the 5-year survival rates are favorable (100%) when there is localized or regional disease only, but once the cancer has metastasized, the rate of survival declines to 30%[5] . This last point demonstrates the importance of evaluating predictors of increased metastatic disease in PCa. A recent retrospective study evaluating over 250 patients wi","cbCaihQ0Tg8EWvrG","https://ap.wps.com/l/cbCaihQ0Tg8EWvrG","pdf",3912439,14,"English","# Abstract\n# Introduction\n# Results\n## Validation Studies","[{\"question\":\"What did the in vivo experiments show regarding tumors in OA and non-OA mice?\",\"answer\":\"Mice with OA developed tumors in 100% of cases, whereas mice without OA developed tumors in 83.4%. Tumor weight correlated with OA severity, and tumors from OA mice had higher Ki-67 expression.\"}]","Osteoarthritis as a Systemic Disease Promoted Prostate Cancer In Vivo and In Vitro | PDF",1790030729,35]