[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332184-105":59,"doc-detail-332184-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","origins-of-cancer-aint-it-just-mature-cells-misbehaving","Origins of cancer - ain’t it just mature cells misbehaving?","","A pervasive view is that undifferentiated stem cells alone generate all other cells and thereby account for the cellular origins of cancer. Emerging evidence shows that fully differentiated cells are plastic: they can be induced to proliferate and can contribute to tissue maintenance, regeneration, and tumorigenesis. This review examines mechanisms by which differentiated cells become cancer cells, including why differentiated division accumulates mutations more readily than stem-cell division.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/origins-of-cancer-aint-it-just-mature-cells-misbehaving/332184/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/origins-of-cancer-aint-it-just-mature-cells-misbehaving/332184.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the traditional view of how cancer originates?","Question",{"text":112,"@type":113},"The traditional view holds that undifferentiated stem cells alone generate all other cells and serve as the origins of cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does the review argue about differentiated cells?",{"text":117,"@type":113},"Differentiated cells are described as plastic, capable of being coaxed to proliferate and playing essential roles in regeneration and tumorigenesis.",{"name":119,"@type":110,"acceptedAnswer":120},"Which mechanisms does the review focus on to explain differentiated cells becoming cancer cells?",{"text":121,"@type":113},"It examines the features of differentiated cell division that make them more susceptible to accumulating mutations, and discusses evolutionarily conserved plasticity programs such as paligenosis and the role of p53.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332184,1790071896,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","Review Article  \nOrigins of cancer: ain’t it just mature cells misbehaving?  \nCharles J Cho1,5, Jeffrey W Brown 2,5 & Jason C Mills 1,3,4 ✉  \nAbstract  \nA pervasive view is that undifferentiated stem cells are alone responsible for generating all other cells and are the origins of cancer. However, emerging evidence demonstrates fully differentiated cells are plastic, can be coaxed to proliferate, and also play essential roles in tissue maintenance, regeneration, and tumorigenesis. Here, we review the mechanisms governing how differentiated cells become cancer cells. First, we examine the unique characteristics of differentiated cell division, focusing on why differentiated cells are more susceptible than stem cells to accumulating mutations. Next, we investigate why the evolution of multicellularity in animals likely required plastic differentiated cells that maintain the capacity to return to the cell cycle and required the tumor suppressor p53 . Finally, we examine an example of an evolutionarily conserved program for the plasticity of differentiated cells, paligenosis, which helps explain the origins of cancers that arise in adults. Altogether, we highlight new perspectives for understanding the development of cancer and new strategies for preventing carcinogenic cellular transformations from occurring.  \nKeywords Differentiation; Multicellularity; p53; Plasticity; Stem Cell Subject Categories Cancer; Development; Evolution & Ecology  \n[https://doi.org/10.1038/s44318-024-00099-0](https://doi.org/10.1038/s44318-024-00099-0)  \nReceived 26 August 2023; Revised 15 March 2024; Accepted 22 March 2024  \nPublished online: 21 May 2024  \nIntroduction  \nSince the mid-19th century, when Rudolf Virchow popularized the idea that omnis cellula e cellula (Virchow, 1860), it has been broadly accepted that any cell in an organism, including cancer cells, must have arisen from another cell. This paradigm naturally led to fundamental questions about the cellular origin of cancer: Which cells are susceptible to transforming into cancer? What causes the transformation, and how does it occur?  \nHere, we will give differentiated cells their due as cells of origin for cancer. We will discuss how the vast majority of cells in every organ are differentiated cells performing their normal physiological functions and that most organs (e.g., pancreas, kidney, and liver) do not  \nhave a dedicated stem cell population despite being susceptible to malignancy, whereas some organs that have active stem cells (e.g., small intestine) rarely undergo malignant transformation. We will discuss in depth why differentiated cells are more prone to accumulate mutations that can lead to transformation. Next, we will provide evidence on the plasticity and proliferative potential of differentiated cells that have existed throughout evolution. Indeed, the recruitment of differentiated cells as facultative stem cells may have evolved as a means to facilitate regeneration after injury. We will discuss the evolutionarily conserved features of a cellular program, paligenosis, that regulates how differentiated cells are recruited back to a progenitor state. Finally, we will explore how understanding plasticity and paligenosis in tumorigenesis might eventually help us to prevent tumors, improve the treatment of existing tumors, and understand the relationship between tumors and aging.  \nThe history of the cancer cell of origin  \nPrior to broad acceptance of Virchow’s omnis cellula e cellula (Virchow, 1860), numerous wide-ranging theories existed to explain the origins of cancer (see Box 1) . By the early 1900s, these had largely coalesced around the three general cancer cell-of-origin candidates as articulated by pathologist George Adami: (1) tissue stem cells; (2) latent embryonic cells; (3) mature, differentiated cells (Adami, 1900) . However, by the end of the 20th century, the professional tissue stem cell explanation of cancer-originating cells had achieved such dominance t","cbCaiky3OtN8H0P2","https://ap.wps.com/l/cbCaiky3OtN8H0P2","pdf",2489193,22,"English","# Introduction\n## The history of the cancer cell of origin","[{\"question\":\"What is the traditional view of how cancer originates?\",\"answer\":\"The traditional view holds that undifferentiated stem cells alone generate all other cells and serve as the origins of cancer.\"},{\"question\":\"What does the review argue about differentiated cells?\",\"answer\":\"Differentiated cells are described as plastic, capable of being coaxed to proliferate and playing essential roles in regeneration and tumorigenesis.\"},{\"question\":\"Which mechanisms does the review focus on to explain differentiated cells becoming cancer cells?\",\"answer\":\"It examines the features of differentiated cell division that make them more susceptible to accumulating mutations, and discusses evolutionarily conserved plasticity programs such as paligenosis and the role of p53.\"}]","Origins of cancer - ain’t it just mature cells misbehaving? | PDF",1789997227,55]