[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443306-105":59,"doc-detail-443306-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","organ-cross-talk-molecular-mechanisms-biological-functions-and-therapeutic-interventions-for-diseases","Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases","","Organ cross-talk, also described as an organ axis or organ interaction network, is summarized as a central biological framework for maintaining physiological homeostasis and mediating responses to environmental stimuli. The review integrates current observations in organ communication research with emphasis on brain, heart, and gut connections, mapping interaction patterns and signaling pathways across health and disease. It also details molecular mechanisms, biological functions, and how therapeutic strategies can be developed using advanced methods and technologies, supporting future network-driven models, diagnostics, and personalized treatment.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/organ-cross-talk-molecular-mechanisms-biological-functions-and-therapeutic-interventions-for-diseases/443306/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/organ-cross-talk-molecular-mechanisms-biological-functions-and-therapeutic-interventions-for-diseases/443306.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What does “organ cross-talk” mean in this review?","Question",{"text":113,"@type":114},"It refers to complex biological communication and feedback between different organs, mediated by mechanical, soluble, and cellular mechanisms to maintain body homeostasis, while dysfunction can arise during pathological states.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which organ connections receive particular focus?",{"text":118,"@type":114},"The review highlights brain, heart, and gut connections, including brain-gut, brain-liver, brain-heart; heart–kidney, heart–lung, heart–liver; and gut–liver, gut–kidney, gut–lung.",{"name":120,"@type":111,"acceptedAnswer":121},"How do the authors describe the role of technology in this field?",{"text":122,"@type":114},"They emphasize how advanced methods and technologies support organ connection research, accelerating understanding of molecular mechanisms and enabling development of therapeutic strategies.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},443306,1791219055,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","Signal Transduction [and Targeted Therapy](and Targeted Therapy www.nature.com/sigtrans)[ www.nature.com/sigtrans](and Targeted Therapy www.nature.com/sigtrans)  \nREVIEW ARTICLE  \nOPEN  \nOrgan cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases  \nHuiting Che 1, Yidan Gao 1, Yonghu Xu2, Hui Xu1, Roland Eils3,4 and Mei Tian 1 ✉  \n\n|  | Organ cross-talk, also known as the organ axis or organ interaction network, plays a vital role in maintaining physiological homeostasis and responding to environmental stimuli. This review comprehensively integrates cutting-edge observations in organ communication research, with a particular focus on the brain, heart, and gut—the three core organs that garner the most attention in organ connection studies. The current state of organ interaction network research is clearly presented as a Sankey diagram. For brain-related connections, the interactions among the brain-gut, brain-liver, and brain-heart connections are thoroughly reviewed; for heart-related connections, the relationships among the heart–kidney, heart–lung, and heart–liver connections are explored in detail; and for gut-related connections, the interactions among the gut–liver, gut–kidney, and gut–lung connections are emphasized. Additional information on other prevalent organ connections is systematically organized in tables for intuitive presentation. Through the integration of profound insights into molecular mechanisms and biological functions, the complex signaling pathways regulating organ interactions in health and disease states have been systematically elucidated. In terms of therapeutic strategy development, numerous directions with potential application value are proposed on the basis of these research findings. Furthermore, this review meticulously discusses the diverse methods and advanced technologies employed in organ connection research, comprehensively highlighting the critical role of technological support in advancing this field. In the future, this review advocates the adoption of network-driven models, innovative diagnostic approaches, and personalized |  |  |\n| --- | --- | --- | --- |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n|  |  |  |  |\n| treatment strategies to offer new perspectives for addressing |  | complex diseases from a systems biology standpoint. |  |\n|  | Signal Transduction and Targeted Therapy (2026)11:8 | ; [https://doi.org/10.1038/s41392-025-02329-1](https://doi.org/10.1038/s41392-025-02329-1) |  |\n|  |  |  |  |\n\nINTRODUCTION  \nOrgan cross-talk research stands at the forefront of life sciences because of its critical role in understanding physiological homeostasis and disease mechanisms.1–5 In this study, “organ”refers to a collection of tissues joined in a structural unit to serve a common function, exemplified by the brain, heart, and gut.6 Organ cross-talk refers to complex biological communication and feedback between different organs and is mediated by mechanical, soluble, and cellular mechanisms, which are essential for maintaining body homeostasis but can result in functional and structural dysfunction in other organs when pathological states occur in one or more organs.7 Traditional medical approaches, which emphasize individual organs through anatomy, physiology, and pathology, have offered valuable insights but fail to address the dynamic interplay among organs. In contrast, organ cross-talk research adopts a systems biology perspective, highlighting the significance of interorgan collaboration in health and disease.8,9  \nThe study of organ cross-talk often begins with disease models. For example, in pulmonary heart disease, chronic lung pathology increases right ventricular afterload, leading to heart failure, exemplifying the lung‒heart axis’s pathological interaction.10 Similarly, in hepatorenal syndrome, liver dysfunc","cbCaiejO6qhxZqZS","https://ap.wps.com/l/cbCaiejO6qhxZqZS","pdf",3481287,29,"English","# Introduction\n## Organ cross-talk as systems biology communication\n## Disease models guiding organ cross-talk research\n## Emerging technologies driving interorgan studies","[{\"question\":\"What does “organ cross-talk” mean in this review?\",\"answer\":\"It refers to complex biological communication and feedback between different organs, mediated by mechanical, soluble, and cellular mechanisms to maintain body homeostasis, while dysfunction can arise during pathological states.\"},{\"question\":\"Which organ connections receive particular focus?\",\"answer\":\"The review highlights brain, heart, and gut connections, including brain-gut, brain-liver, brain-heart; heart–kidney, heart–lung, heart–liver; and gut–liver, gut–kidney, gut–lung.\"},{\"question\":\"How do the authors describe the role of technology in this field?\",\"answer\":\"They emphasize how advanced methods and technologies support organ connection research, accelerating understanding of molecular mechanisms and enabling development of therapeutic strategies.\"}]","Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases | PDF",1790703570,73]